Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0L3MB)
DIG Name	FD&C blue no. 2
Synonyms	Click to Show/Hide the Synonyms of This DIG Indigo carmine; 860-22-0; Acid Blue 74; indigocarmine; Indigotindisulfonate sodium; Sodium 3,3'-dioxo-[2,2'-biindolinylidene]-5,5'-disulfonate; C.I. ACID BLUE 74; Indigocarmin; Indigotine; FD&C Blue No. 2; Food Blue No. 2; FD and C Blue No. 2; Sachsischblau; Murabba; Amacid Brilliant Blue; Indigotine Lake; Indigo Extract; Indocarmine F; Soluble Indigo; Disodium 5,5'-disulfoindigo; Indigotine B; Indigotine I; Indigotine N; Intense Blue; Indigotin I; Indigotine IA; C.I. Food Blue 1; Cilefa Blue R; Indigo Carmine A; Indigo Carmine X; C.I. Natural Blue 2; Grape Blue A; Airedale Blue IN; Acid Blue W; Sodium indigo-5,5'-bisulfonate; Sodium indigotindisulfonate; HD Indigo Carmine; Indigo Carmine AC; Indigo Carmine BP; Food Blue 2; Indigotine Blue LZ; Atul Indigo Carmine; Bucacid indigotine B; Indigo-5,5'-disulfonic acid disodium salt; Grape Blue A Geigy; Maple Indigo Carmine; Edicol Supra Blue X; Indigo Carmine Powder; Mitsui Indigo Carmine; Aniline Carmine powder; Acid Leather Blue IC; Dolkwal Indigo Carmine; San-ei Indigo Carmine; Usacert Blue No. 2; Hexacert Blue No. 2; Canacert Indigo Carmine; Indigotine disodium salt; UNII-D3741U8K7L; Indigotine Conc. Powder; Indigotine Extra Pure A; Sumitomo Wool Blue SBC; Disodium indigo-5,5-disulfonate; HD Indigo Carmine Supra; Sodium 5,5'-indigotindisulfonate; CI 73015; A.F. Blue No. 2; Indigo Carmine Conc. FQ; 1311 Blue; C.I. Food Blue 1, disodium salt; FD & C blue no. 2; C.I. 73015; C.I. 75781; Disodium 5,5'-indigotin disulfonate; E 132; L Blue Z 5010; 12070 Blue; Indigotin-5,5'-disulfonic acid disodium salt; Hexacol Indigo Carmine Supra; Indigo Carmine Disodium Salt; Carmine Blue (biological stain); Indigo Carmine (Biological Stain); 1H-Indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, disodium salt; CHEBI:31695; Disodium 3,3'-dioxo-(delta2,2'-biindoline)-5,5'-disulfonate; Indigo disulfonate (Biological Stain); Indigotindisulfonate sodium [USP]; D3741U8K7L; Indigo Carmine (C.I. 73015); MFCD00005723; Disodium salt of 1-indigotin-S,S'-disulfonic acid; DSSTox_CID_190; Soluble Indigo Blue; Food Blue 1:1; DSSTox_RID_75423; DSSTox_GSID_20190; Indigo Carmine, pure, certified; Indigotindisulfonate sodium (USP); L-Blau 2 [German]; Indigo-karmin [German]; Indigo-karmin; Modr Kysela 74 [Czech]; disodium (2E)-3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate; Modr Pigment 63 [Czech]; Modr Pigment 63; 1H-Indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, sodium salt (1:2); CAS-860-22-0; Modr Kysela 74; Modr Potravinarska 1 [Czech]; CCRIS 1865; Modr Potravinarska 1; Schultz Nr. 1309 [German]; L-Blau 2; Schultz Nr. 1309; NCGC00187606-01; NSC 8646; Dinatrium indigolin-5,5'-disulfonat; EINECS 212-728-8; FD &C Blue No. 2; Indigo Carmine, for analysis, high purity biological stain; AI3-09087; Airdale blue IN; HSDB 7875; Natural blue 2; disodium;(2E)-3-oxo-2-(3-oxo-5-sulfonato-1H-indol-2-ylidene)-1H-indole-5-sulfonate; Indigotine Conc. Powder; Indigotine Extra Pure A; Disodium salt of 1-indigotin-S,S'-disulphonic acid; AF blue no. 2; Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate; Indigo carmine (TN); Indigocarmine (JP17); Dinatrium 3,3'-dioxo-(delta2,2'-biindolin)-5,5'-disulfonat; Disodium 3,3'-dioxo-(delta(sup 2,2')-biindoline)-5,5'-disulfonate; (delta2,2'-Biindoline)-5,5'-disulfonic acid, 3,3'-dioxo-, disodium salt; Sodium indigotin disulfonate; SCHEMBL40486; Disodium 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-1H-indole-5-sulfonate; C16H8N2Na2O8S2; SCHEMBL118376; C16H8N2O8S2.2Na; 5,5'-Indigotin disulfonic acid; CHEMBL2105023; DTXSID1020190; Indigo carmine, p.a., 80.0%; Indigo carmine, analytical standard; AMY22391; Tox21_113456; Tox21_302732; AKOS015902370; AKOS016011136; CCG-269417; (delta(sup 2,2')-Biindoline)-5,5'-disulfonic acid, 3,3'-dioxo-, disodium salt; NCGC00256411-01; 2-(1,3-Dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-1H-indole-5-sulfonic acid, disodium salt; disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate; M573; T604; DB-056895; F0148; FT-0627198; I0214; ST51007287; Indigo carmine, SAJ first grade, >=90.0%; D01563; Indigo carmine, JIS special grade, >=97.5%; Indigotine 100 microg/mL in Acetonitrile:Water; Q410120; UNII-L06K8R7DQK component KHLVKKOJDHCJMG-QDBORUFSSA-L; 3,3'-Dioxo-(delta2,2'-biindoline)-5,5'-disulfonic acid disodium salt; Indigo carmine, for microscopy (Bact., Hist.), indicator (pH 11.5-14.0); (delta2,2'-Biindoline)-5,5'-disulfonic acid, 3,3'-dioxo-, disodium salt (8CI); Indigo carmine, certified by the Biological Stain Commission, Dye content 85 %; Indigotindisulfonate sodium, United States Pharmacopeia (USP) Reference Standard; 2-(1,3-dihydro-3-oxo-5-sulfo-2h-indol-2-ylidene)-2,3-dihydro-3-oxo-1h-indole-5-sulfonic acid disodium salt; 3-oxo-2-(3-oxo-5-sulfo(1H-benzo[d]azolin-2-ylidene))-1H-benzo[d]azoline-5-sulf onic acid, sodium salt, sodium salt
DIG Function	Colorant
PubChem CID	2723854
Formula	C16H8N2Na2O8S2
Canonical SMILES	C1=CC2=C(C=C1S(=O)(=O)[O-])C(=C(N2)C3=NC4=C(C3=O)C=C(C=C4)S(=O)(=O)[O-])O.[Na+].[Na+]
InChI	1S/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17,19H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2
InChIKey	JFVXEJADITYJHK-UHFFFAOYSA-L
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2723854"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	466.4	Topological Polar Surface Area	197
	XlogP	N.A.	Complexity	877
	Heavy Atom Count	30	Rotatable Bond Count	1
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count	9

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[1]
Minocycline	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[2]
Valacyclovir	API Info	Herpes zoster [ICD-11: 1E91]		[3]
Metronidazole	API Info	Amebiasis [ICD-11: 1A36]		[4]
Acyclovir	API Info	Herpes zoster [ICD-11: 1E91]		[5]
Didanosine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[6]
Oseltamivir	API Info	Influenza virus infection [ICD-11: 1E30]		[7]
Ribavirin	API Info	Viral hepatitis [ICD-11: 1E51]		[8]
Tetracycline	API Info	Spotted fever [ICD-11: 1C31]		[9]
Dicloxacillin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[10]
Vancomycin	API Info	Methicillin-resistant staphylococcus infection [ICD-11: 1D01]		[11]
Cefaclor	API Info	Clostridium difficile infection [ICD-11: 1A04]		[12]
Itraconazole	API Info	Blastomycosis [ICD-11: 1F22]		[13]
Maraviroc	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[14]
Atazanavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[15]
Efavirenz	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[16]
Linezolid	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[17]
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[18]
Primaquine	API Info	Malaria [ICD-11: 1F40]		[19]
Daclatasvir	API Info	Viral hepatitis [ICD-11: 1E51]		[20]
Emtricitabine	API Info	Viral hepatitis [ICD-11: 1E51]		[21]
Nelfinavir	API Info	Coronavirus infection [ICD-11: 1D92]		[22]
Paromomycin	API Info	Amebiasis [ICD-11: 1A36]		[23]
Tenofovir disoproxil	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[24]
Elvitegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[25]
Ganciclovir	API Info	Cytomegalovirus infection [ICD-11: 1D82]		[26]
Rifapentine	API Info	Pulmonary tuberculosis [ICD-11: 1B10]		[27]
Saquinavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[28]
Telaprevir	API Info	Viral hepatitis [ICD-11: 1E51]		[29]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Temozolomide	API Info	Brain cancer [ICD-11: 2A00]		[30]
Hydroxyurea	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[31]
Letrozole	API Info	Breast cancer [ICD-11: 2C60]		[32]
Flutamide	API Info	Prostate cancer [ICD-11: 2C82]		[33]
Methotrexate	API Info	Breast cancer [ICD-11: 2C60]		[34]
Nystatin	API Info	Acute lymphoblastic leukemia [ICD-11: 2B33]		[35]
Methyltestosterone	API Info	Breast cancer [ICD-11: 2C60]		[36]
Capecitabine	API Info	Colon cancer [ICD-11: 2B90]		[37]
Acalabrutinib	API Info	Mantle cell lymphoma [ICD-11: 2A85]		[38]
Alectinib	API Info	Lung cancer [ICD-11: 2C25]		[39]
Ceritinib	API Info	Lung cancer [ICD-11: 2C25]		[40]
Rucaparib	API Info	Ovarian cancer [ICD-11: 2C73]		[41]
ICD Disease Classification 03		Blood/blood-forming organ disease	Click to Show/Hide
Eltrombopag	API Info	Thrombocytopenia [ICD-11: 3B64]		[42]
Anagrelide	API Info	Thrombocytosis [ICD-11: 3B63]		[43]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[44]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Levothroid	API Info	Hypothyroidism [ICD-11: 5A00]		[45]
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[46]
Phentermine	API Info	Obesity [ICD-11: 5B81]		[47]
Potassium chloride	API Info	Hypokalemia [ICD-11: 5C77]		[48]
Glipizide	API Info	Diabetes mellitus [ICD-11: 5A10]		[49]
Glimepiride	API Info	Diabetes mellitus [ICD-11: 5A10]		[50]
Glyburide	API Info	Diabetes mellitus [ICD-11: 5A10]		[51]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[52]
Lovastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[53]
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[54]
Calcium acetate	API Info	Hyperphosphatemia [ICD-11: 5C64]		[55]
Fenofibric acid	API Info	Dyslipidaemia [ICD-11: 5C81]		[56]
Bromocriptine	API Info	Diabetes mellitus [ICD-11: 5A10]		[57]
Estropipate	API Info	Hypogonadism [ICD-11: 5A61]		[58]
Probenecid	API Info	Hyperuricaemia [ICD-11: 5C55]		[59]
Cysteamine	API Info	Nephropathic cystinosis [ICD-11: 5C60]		[60]
Orlistat	API Info	Obesity [ICD-11: 5B81]		[61]
Lorcaserin	API Info	Obesity [ICD-11: 5B81]		[62]
Sibutramine	API Info	Obesity [ICD-11: 5B81]		[63]
Trientine	API Info	Hyperphosphatemia [ICD-11: 5C64]		[64]
Zinc acetate	API Info	Hyperphosphatemia [ICD-11: 5C64]		[65]
Eliglustat	API Info	Gaucher disease [ICD-11: 5C56]		[66]
Metyrosine	API Info	Pheochromocytoma [ICD-11: 5A75]		[67]
Tolvaptan	API Info	Hyponatraemia [ICD-11: 5C72]		[68]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Risperidone	API Info	Schizophrenia [ICD-11: 6A20]		[69]
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[70]
Alprazolam	API Info	Anxiety disorder [ICD-11: 6B00]		[71]
Lamotrigine	API Info	Bipolar disorder [ICD-11: 6A60]		[72]
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[73]
Duloxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[74]
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[75]
Amitriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[76]
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[77]
Aripiprazole	API Info	Schizophrenia [ICD-11: 6A20]		[78]
Hydroxyzine	API Info	Anxiety disorder [ICD-11: 6B00]		[79]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[80]
Dexmethylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[81]
Ziprasidone	API Info	Schizophrenia [ICD-11: 6A20]		[82]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[83]
Atomoxetine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[84]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[85]
Guanfacine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[86]
Lithium carbonate	API Info	Bipolar disorder [ICD-11: 6A60]		[87]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[88]
Mirtazapine	API Info	Major depressive disorder [ICD-11: 6A70]		[89]
Nortriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[90]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[91]
Prochlorperazine	API Info	Schizophrenia [ICD-11: 6A20]		[92]
Sinequan	API Info	Major depressive disorder [ICD-11: 6A70]		[93]
Desipramine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[94]
Fluvoxamine	API Info	Obsessive-compulsive disorder [ICD-11: 6B20]		[95]
Chlorpromazine	API Info	Schizophrenia [ICD-11: 6A20]		[96]
Loxapine	API Info	Schizophrenia [ICD-11: 6A20]		[97]
Fluphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[98]
Trazodone	API Info	Major depressive disorder [ICD-11: 6A70]		[99]
Clozapine	API Info	Schizophrenia [ICD-11: 6A20]		[100]
Chlordiazepoxide	API Info	Anxiety disorder [ICD-11: 6B00]		[101]
Paliperidone	API Info	Bipolar disorder [ICD-11: 6A60]		[102]
Trifluoperazine	API Info	Schizophrenia [ICD-11: 6A20]		[103]
Clomipramine	API Info	Obsessive-compulsive disorder [ICD-11: 6B20]		[104]
Tiotixene	API Info	Schizophrenia [ICD-11: 6A20]		[105]
Trimipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[106]
Oxazepam	API Info	Anxiety disorder [ICD-11: 6B00]		[107]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[108]
Milnacipran	API Info	Asperger syndrome [ICD-11: 6A02]		[109]
Amoxapine	API Info	Major depressive disorder [ICD-11: 6A70]		[110]
Varenicline	API Info	Nicotine dependence [ICD-11: 6C4A]		[111]
Molindone	API Info	Schizophrenia [ICD-11: 6A20]		[112]
Clorazepate	API Info	Anxiety disorder [ICD-11: 6B00]		[113]
Lurasidone	API Info	Schizophrenia [ICD-11: 6A20]		[114]
Naltrexone	API Info	Alcohol dependence [ICD-11: 6C40]		[115]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Dextroamphetamine	API Info	Narcolepsy [ICD-11: 7A20]		[116]
Temazepam	API Info	Insomnia [ICD-11: 7A00]		[117]
Zolpidem	API Info	Insomnia [ICD-11: 7A00]		[118]
Eszopiclone	API Info	Insomnia [ICD-11: 7A00]		[119]
Zaleplon	API Info	Insomnia [ICD-11: 7A00]		[120]
Flurazepam	API Info	Insomnia [ICD-11: 7A00]		[121]
Triazolam	API Info	Insomnia [ICD-11: 7A00]		[122]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[123]
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[124]
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[125]
Oxycodone	API Info	Anaesthesia [ICD-11: 8E22]		[126]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[127]
Pramipexole	API Info	Parkinsonism [ICD-11: 8A00]		[128]
Propranolol	API Info	Migraine [ICD-11: 8A80]		[129]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[130]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[131]
Tramadol	API Info	Anaesthesia [ICD-11: 8E22]		[132]
Carbamazepine	API Info	Epilepsy [ICD-11: 8A60]		[133]
Clonazepam	API Info	Epilepsy [ICD-11: 8A60]		[134]
Tizanidine	API Info	Tic disorder [ICD-11: 8A05]		[135]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[136]
Oxymorphone	API Info	Anaesthesia [ICD-11: 8E22]		[137]
Phenytoin	API Info	Epilepsy [ICD-11: 8A60]		[138]
Galantamine	API Info	Alzheimer disease [ICD-11: 8A20]		[139]
Oxcarbazepine	API Info	Epilepsy [ICD-11: 8A60]		[140]
Hydromorphone	API Info	Anaesthesia [ICD-11: 8E22]		[141]
Zonisamide	API Info	Epilepsy [ICD-11: 8A60]		[142]
Memantine	API Info	Alzheimer disease [ICD-11: 8A20]		[143]
Hydrocodone	API Info	Anaesthesia [ICD-11: 8E22]		[144]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[145]
Rivastigmine	API Info	Alzheimer disease [ICD-11: 8A20]		[146]
Tiagabine	API Info	Epilepsy [ICD-11: 8A60]		[147]
Almotriptan	API Info	Migraine [ICD-11: 8A80]		[148]
Eletriptan	API Info	Migraine [ICD-11: 8A80]		[149]
Ketoprofen	API Info	Anaesthesia [ICD-11: 8E22]		[150]
Tapentadol	API Info	Neuropathic pain [ICD-11: 8E43]		[151]
Carbidopa	API Info	Parkinsonism [ICD-11: 8A00]		[152]
Naratriptan	API Info	Migraine [ICD-11: 8A80]		[153]
Lacosamide	API Info	Epilepsy [ICD-11: 8A60]		[154]
Deutetrabenazine	API Info	Huntington disease [ICD-11: 8A01]		[155]
Droxidopa	API Info	Neurogenic orthostatic hypotension [ICD-11: 8D87]		[156]
Ezogabine	API Info	Epilepsy [ICD-11: 8A60]		[157]
Pentosan polysulfate	API Info	Anaesthesia [ICD-11: 8E22]		[158]
Perampanel	API Info	Focal seizure [ICD-11: 8A68]		[159]
Teriflunomide	API Info	Multiple sclerosis [ICD-11: 8A40]		[160]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[161]
Pilocarpine	API Info	Glaucoma [ICD-11: 9C61]		[162]
Acetazolamide	API Info	Glaucoma [ICD-11: 9C61]		[163]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[164]
Amoxicillin	API Info	Acute otitis media [ICD-11: AB00]		[165]
Cephalexin	API Info	Acute otitis media [ICD-11: AB00]		[166]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Diltiazem	API Info	Essential hypertension [ICD-11: BA00]		[167]
Lisinopril	API Info	Essential hypertension [ICD-11: BA00]		[168]
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[169]
Metoprolol	API Info	Essential hypertension [ICD-11: BA00]		[170]
Warfarin	API Info	Atrial fibrillation [ICD-11: BC81]		[171]
Ramipril	API Info	Essential hypertension [ICD-11: BA00]		[172]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[173]
Clonidine	API Info	Essential hypertension [ICD-11: BA00]		[174]
Losartan	API Info	Essential hypertension [ICD-11: BA00]		[175]
Doxazosin	API Info	Essential hypertension [ICD-11: BA00]		[176]
Enalapril	API Info	Essential hypertension [ICD-11: BA00]		[177]
Caffeine	API Info	Orthostatic hypotension [ICD-11: BA21]		[178]
Felodipine	API Info	Essential hypertension [ICD-11: BA00]		[179]
Amlodipine	API Info	Angina pectoris [ICD-11: BA40]		[180]
Nifedipine	API Info	Angina pectoris [ICD-11: BA40]		[181]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[182]
Valsartan	API Info	Essential hypertension [ICD-11: BA00]		[183]
Propafenone	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[184]
Sotalol	API Info	Atrial fibrillation [ICD-11: BC81]		[185]
Benazepril	API Info	Essential hypertension [ICD-11: BA00]		[186]
Carvedilol	API Info	Congestive heart failure [ICD-11: BD10]		[187]
Trandolapril	API Info	Essential hypertension [ICD-11: BA00]		[188]
Nadolol	API Info	Essential hypertension [ICD-11: BA00]		[189]
Midodrine	API Info	Orthostatic hypotension [ICD-11: BA21]		[190]
Nisoldipine	API Info	Essential hypertension [ICD-11: BA00]		[191]
Labetalol	API Info	Essential hypertension [ICD-11: BA00]		[192]
Isosorbide mononitrate	API Info	Angina pectoris [ICD-11: BA40]		[193]
Nitroglycerin	API Info	Acute coronary syndrome [ICD-11: BA4Z]		[194]
Dipyridamole	API Info	Atherosclerosis [ICD-11: BA80]		[195]
Acebutolol	API Info	Essential hypertension [ICD-11: BA00]		[196]
Metolazone	API Info	Congestive heart failure [ICD-11: BD10]		[197]
Disopyramide	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[198]
Nebivolol	API Info	Pulmonary hypertension [ICD-11: BB01]		[199]
Pentoxifylline	API Info	Intermittent claudication [ICD-11: BD40]		[200]
Methyldopa	API Info	Essential hypertension [ICD-11: BA00]		[201]
Nicardipine	API Info	Essential hypertension [ICD-11: BA00]		[202]
Bisoprolol	API Info	Essential hypertension [ICD-11: BA00]		[203]
Isradipine	API Info	Essential hypertension [ICD-11: BA00]		[204]
Mexiletine	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[205]
Timolol	API Info	Essential hypertension [ICD-11: BA00]		[206]
Quinapril	API Info	Essential hypertension [ICD-11: BA00]		[207]
Dabigatran etexilate	API Info	Venous thromboembolism [ICD-11: BD72]		[208]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[209]
Clarithromycin	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[210]
Chlorpheniramine	API Info	Allergic rhinitis [ICD-11: CA08]		[211]
Promethazine	API Info	Allergic rhinitis [ICD-11: CA08]		[212]
Loratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[213]
Cefdinir	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[214]
Desloratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[215]
Cefadroxil	API Info	Acute tonsillitis [ICD-11: CA03]		[216]
Budesonide	API Info	Allergic rhinitis [ICD-11: CA08]		[217]
Levofloxacin	API Info	Bronchitis [ICD-11: CA20]		[218]
Salbutamol	API Info	Chronic obstructive pulmonary disease [ICD-11: CA22]		[219]
Theophylline	API Info	Chronic obstructive pulmonary disease [ICD-11: CA22]		[220]
Ivacaftor	API Info	Cystic fibrosis [ICD-11: CA25]		[221]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Doxycycline	API Info	Periodontal disease [ICD-11: DA0C]		[222]
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[223]
Bisacodyl	API Info	Irritable bowel syndrome [ICD-11: DD91]		[224]
Pantoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[225]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[226]
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[227]
Ranitidine	API Info	Gastric ulcer [ICD-11: DA60]		[228]
Esomeprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[229]
Loperamide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[230]
Dicyclomine	API Info	Irritable bowel syndrome [ICD-11: DD91]		[231]
Ondansetron	API Info	Gastritis [ICD-11: DA42]		[232]
Mycophenolate mofetil	API Info	Crohn disease [ICD-11: DD70]		[233]
Rabeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[234]
Tacrolimus	API Info	Ulcerative colitis [ICD-11: DD71]		[235]
Ursodeoxycholic acid	API Info	Hepatic fibrosis/cirrhosis [ICD-11: DB93]		[236]
Nizatidine	API Info	Peptic ulcer [ICD-11: DA61]		[237]
Mycophenolic acid	API Info	Crohn disease [ICD-11: DD70]		[238]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[239]
Trimethobenzamide	API Info	Functional nausea/vomiting [ICD-11: DD90]		[240]
Dexlansoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[241]
Balsalazide	API Info	Ulcerative colitis [ICD-11: DD71]		[242]
Alosetron	API Info	Irritable bowel syndrome [ICD-11: DD91]		[243]
Nitazoxanide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[244]
Rolapitant	API Info	Functional nausea/vomiting [ICD-11: DD90]		[245]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Hydrochlorothiazide	API Info	Luid retention [ICD-11: EF02]		[246]
Clindamycin	API Info	Acne vulgaris [ICD-11: ED80]		[247]
Isotretinoin	API Info	Acne vulgaris [ICD-11: ED80]		[248]
Acitretin	API Info	Psoriasis vulgaris [ICD-11: EA90]		[249]
Tretinoin	API Info	Acne vulgaris [ICD-11: ED80]		[250]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Naproxen	API Info	Rheumatoid arthritis [ICD-11: FA20]		[251]
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[252]
Celecoxib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[253]
Diclofenac	API Info	Knee osteoarthritis [ICD-11: FA01]		[254]
Etodolac	API Info	Rheumatoid arthritis [ICD-11: FA20]		[255]
Meloxicam	API Info	Rheumatoid arthritis [ICD-11: FA20]		[256]
Piroxicam	API Info	Rheumatoid arthritis [ICD-11: FA20]		[257]
Cyclosporin A	API Info	Rheumatoid arthritis [ICD-11: FA20]		[258]
Rifampicin	API Info	Osteoporosis [ICD-11: FB83]		[259]
Conjugated estrogen	API Info	Osteoporosis [ICD-11: FB83]		[260]
Risedronic acid	API Info	Paget's disease [ICD-11: FB85]		[261]
Diflunisal	API Info	Osteoporosis [ICD-11: FB83]		[262]
Colchicine	API Info	Uncontrolled gout [ICD-11: FA25]		[263]
Tolmetin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[264]
Lesinurad	API Info	Uncontrolled gout [ICD-11: FA25]		[265]
Tofacitinib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[266]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[267]
Terazosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[268]
Finasteride	API Info	Prostatic hyperplasia [ICD-11: GA90]		[269]
Oxybutynin	API Info	Overactive bladder [ICD-11: GC50]		[270]
Tamsulosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[271]
Nitrofurantoin	API Info	Infectious cystitis [ICD-11: GC00]		[272]
Tolterodine	API Info	Overactive bladder [ICD-11: GC50]		[273]
Danazol	API Info	Endometriosis [ICD-11: GA10]		[274]
Mefenamic acid	API Info	Dysmenorrhea [ICD-11: GA34]		[275]
Methenamine	API Info	Urinary tract infection [ICD-11: GC08]		[276]
Fesoterodine	API Info	Overactive bladder [ICD-11: GC50]		[277]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[278]
ICD Disease Classification 17		Sexual health-related condition	Click to Show/Hide
Sildenafil	API Info	Erectile dysfunction [ICD-11: HA01]		[279]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
G-protein coupled receptor (GPCR)
DBT Name: Adenosine receptor A3 (AA3R)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 1 uM (tested by experiment)		[280]
Tested Species	Homo sapiens (Human)
UniProt ID	AA3R_HUMAN
Oxidoreductase (ORase)
DBT Name: Monoamine oxidase A (MAO-A)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 > 3 uM (tested by experiment)		[280]
Tested Species	Homo sapiens (Human)
UniProt ID	AOFA_HUMAN
DBT Name: Prostaglandin G/H synthase 2 (COX-2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 24 uM (tested by experiment)		[280]
Tested Species	Homo sapiens (Human)
UniProt ID	PGH2_HUMAN
Transferase (TFase)
DBT Name: VEGF-2 receptor (KDR)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 3.1 uM (tested by experiment)		[280]
Tested Species	Homo sapiens (Human)
UniProt ID	VGFR2_HUMAN
Hydrolase (HDase)
DBT Name: Protein-tyrosine phosphatase 1D (PTPN11)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 7940 nM (estimated based on the structural similarity with CHEMBL3692077 )		[281]
Structural Similarity	Tanimoto coefficient = 0.822222222
Tested Species	Homo sapiens (Human)
UniProt ID	PTN11_HUMAN
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 26 % (tested by experiment)		[282]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Nuclear receptor (NR)
DBT Name: Estrogen receptor alpha (ESR1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 > 10 uM (tested by experiment)		[280]
Tested Species	Homo sapiens (Human)
UniProt ID	ESR1_HUMAN

References
1	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved minocycline from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved valacyclovir from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved metronidazole from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved acyclovir from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved didanosine from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved oseltamivir from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved ribavirin from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved tetracycline from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved dicloxacillin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved vancomycin from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved cefaclor from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved itraconazole from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved maraviroc from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved atazanavir from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved efavirenz from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved linezolid from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved primaquine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved daclatasvir from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved emtricitabine from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved nelfinavir from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved paromomycin from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved tenofovir disoproxil from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved elvitegravir from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved ganciclovir from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved rifapentine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved saquinavir from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved telaprevir from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved temozolomide from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved hydroxyurea from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved letrozole from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved flutamide from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved methotrexate from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved nystatin from the official website of the U.S. Food and Drug Administration.
36	Oral androgens in the treatment of hypogonadal impotent men. J Urol. 1994 Oct;152(4):1115-8.
37	FDA label for approved capecitabine from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved acalabrutinib from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved alectinib from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved ceritinib from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved rucaparib from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved eltrombopag from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved anagrelide from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved levothroid from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved potassium chloride from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved glipizide from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved glimepiride from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved glyburide from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved lovastatin from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved calcium acetate from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved fenofibric acid from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved bromocriptine from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved estropipate from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved probenecid from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved cysteamine from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved orlistat from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved lorcaserin from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved sibutramine from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved trientine from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved zinc acetate from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved eliglustat from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved metyrosine from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved tolvaptan from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved alprazolam from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved lamotrigine from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved duloxetine from the official website of the U.S. Food and Drug Administration.
75	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
76	FDA label for approved amitriptyline from the official website of the U.S. Food and Drug Administration.
77	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
78	FDA label for approved aripiprazole from the official website of the U.S. Food and Drug Administration.
79	FDA label for approved hydroxyzine from the official website of the U.S. Food and Drug Administration.
80	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
81	FDA label for approved dexmethylphenidate from the official website of the U.S. Food and Drug Administration.
82	FDA label for approved ziprasidone from the official website of the U.S. Food and Drug Administration.
83	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
84	FDA label for approved atomoxetine from the official website of the U.S. Food and Drug Administration.
85	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
86	FDA label for approved guanfacine from the official website of the U.S. Food and Drug Administration.
87	FDA label for approved lithium carbonate from the official website of the U.S. Food and Drug Administration.
88	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
89	FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
90	FDA label for approved nortriptyline from the official website of the U.S. Food and Drug Administration.
91	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
92	FDA label for approved prochlorperazine from the official website of the U.S. Food and Drug Administration.
93	FDA label for approved sinequan from the official website of the U.S. Food and Drug Administration.
94	FDA label for approved desipramine from the official website of the U.S. Food and Drug Administration.
95	FDA label for approved fluvoxamine from the official website of the U.S. Food and Drug Administration.
96	FDA label for approved chlorpromazine from the official website of the U.S. Food and Drug Administration.
97	FDA label for approved loxapine from the official website of the U.S. Food and Drug Administration.
98	FDA label for approved fluphenazine from the official website of the U.S. Food and Drug Administration.
99	FDA label for approved trazodone from the official website of the U.S. Food and Drug Administration.
100	FDA label for approved clozapine from the official website of the U.S. Food and Drug Administration.
101	FDA label for approved chlordiazepoxide from the official website of the U.S. Food and Drug Administration.
102	FDA label for approved paliperidone from the official website of the U.S. Food and Drug Administration.
103	FDA label for approved trifluoperazine from the official website of the U.S. Food and Drug Administration.
104	FDA label for approved clomipramine from the official website of the U.S. Food and Drug Administration.
105	FDA label for approved tiotixene from the official website of the U.S. Food and Drug Administration.
106	FDA label for approved trimipramine from the official website of the U.S. Food and Drug Administration.
107	FDA label for approved oxazepam from the official website of the U.S. Food and Drug Administration.
108	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
109	FDA label for approved milnacipran from the official website of the U.S. Food and Drug Administration.
110	FDA label for approved amoxapine from the official website of the U.S. Food and Drug Administration.
111	FDA label for approved varenicline from the official website of the U.S. Food and Drug Administration.
112	FDA label for approved molindone from the official website of the U.S. Food and Drug Administration.
113	FDA label for approved clorazepate from the official website of the U.S. Food and Drug Administration.
114	FDA label for approved lurasidone from the official website of the U.S. Food and Drug Administration.
115	FDA label for approved naltrexone from the official website of the U.S. Food and Drug Administration.
116	FDA label for approved dextroamphetamine from the official website of the U.S. Food and Drug Administration.
117	FDA label for approved temazepam from the official website of the U.S. Food and Drug Administration.
118	FDA label for approved zolpidem from the official website of the U.S. Food and Drug Administration.
119	FDA label for approved eszopiclone from the official website of the U.S. Food and Drug Administration.
120	FDA label for approved zaleplon from the official website of the U.S. Food and Drug Administration.
121	FDA label for approved flurazepam from the official website of the U.S. Food and Drug Administration.
122	FDA label for approved triazolam from the official website of the U.S. Food and Drug Administration.
123	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
124	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
125	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
126	Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology. 1998 Jun;50(6):1837-41.
127	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
128	FDA label for approved pramipexole from the official website of the U.S. Food and Drug Administration.
129	FDA label for approved propranolol from the official website of the U.S. Food and Drug Administration.
130	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
131	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
132	FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
133	FDA label for approved carbamazepine from the official website of the U.S. Food and Drug Administration.
134	FDA label for approved clonazepam from the official website of the U.S. Food and Drug Administration.
135	FDA label for approved tizanidine from the official website of the U.S. Food and Drug Administration.
136	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
137	FDA label for approved oxymorphone from the official website of the U.S. Food and Drug Administration.
138	FDA label for approved phenytoin from the official website of the U.S. Food and Drug Administration.
139	FDA label for approved galantamine from the official website of the U.S. Food and Drug Administration.
140	FDA label for approved oxcarbazepine from the official website of the U.S. Food and Drug Administration.
141	FDA label for approved hydromorphone from the official website of the U.S. Food and Drug Administration.
142	FDA label for approved zonisamide from the official website of the U.S. Food and Drug Administration.
143	FDA label for approved memantine from the official website of the U.S. Food and Drug Administration.
144	FDA label for approved hydrocodone from the official website of the U.S. Food and Drug Administration.
145	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
146	FDA label for approved rivastigmine from the official website of the U.S. Food and Drug Administration.
147	FDA label for approved tiagabine from the official website of the U.S. Food and Drug Administration.
148	FDA label for approved almotriptan from the official website of the U.S. Food and Drug Administration.
149	FDA label for approved eletriptan from the official website of the U.S. Food and Drug Administration.
150	FDA label for approved ketoprofen from the official website of the U.S. Food and Drug Administration.
151	FDA label for approved tapentadol from the official website of the U.S. Food and Drug Administration.
152	FDA label for approved carbidopa from the official website of the U.S. Food and Drug Administration.
153	FDA label for approved naratriptan from the official website of the U.S. Food and Drug Administration.
154	FDA label for approved lacosamide from the official website of the U.S. Food and Drug Administration.
155	FDA label for approved deutetrabenazine from the official website of the U.S. Food and Drug Administration.
156	FDA label for approved droxidopa from the official website of the U.S. Food and Drug Administration.
157	FDA label for approved ezogabine from the official website of the U.S. Food and Drug Administration.
158	FDA label for approved pentosan polysulfate from the official website of the U.S. Food and Drug Administration.
159	FDA label for approved perampanel from the official website of the U.S. Food and Drug Administration.
160	FDA label for approved teriflunomide from the official website of the U.S. Food and Drug Administration.
161	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
162	FDA label for approved pilocarpine from the official website of the U.S. Food and Drug Administration.
163	FDA label for approved acetazolamide from the official website of the U.S. Food and Drug Administration.
164	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
165	FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
166	FDA label for approved cephalexin from the official website of the U.S. Food and Drug Administration.
167	FDA label for approved diltiazem from the official website of the U.S. Food and Drug Administration.
168	FDA label for approved lisinopril from the official website of the U.S. Food and Drug Administration.
169	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
170	FDA label for approved metoprolol from the official website of the U.S. Food and Drug Administration.
171	FDA label for approved warfarin from the official website of the U.S. Food and Drug Administration.
172	FDA label for approved ramipril from the official website of the U.S. Food and Drug Administration.
173	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
174	FDA label for approved clonidine from the official website of the U.S. Food and Drug Administration.
175	FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
176	FDA label for approved doxazosin from the official website of the U.S. Food and Drug Administration.
177	FDA label for approved enalapril from the official website of the U.S. Food and Drug Administration.
178	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
179	FDA label for approved felodipine from the official website of the U.S. Food and Drug Administration.
180	FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
181	FDA label for approved nifedipine from the official website of the U.S. Food and Drug Administration.
182	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
183	FDA label for approved valsartan from the official website of the U.S. Food and Drug Administration.
184	FDA label for approved flecainide from the official website of the U.S. Food and Drug Administration.
185	FDA label for approved sotalol from the official website of the U.S. Food and Drug Administration.
186	FDA label for approved benazepril from the official website of the U.S. Food and Drug Administration.
187	FDA label for approved carvedilol from the official website of the U.S. Food and Drug Administration.
188	FDA label for approved trandolapril from the official website of the U.S. Food and Drug Administration.
189	FDA label for approved nadolol from the official website of the U.S. Food and Drug Administration.
190	FDA label for approved midodrine from the official website of the U.S. Food and Drug Administration.
191	FDA label for approved nisoldipine from the official website of the U.S. Food and Drug Administration.
192	FDA label for approved labetalol from the official website of the U.S. Food and Drug Administration.
193	FDA label for approved isosorbide mononitrate from the official website of the U.S. Food and Drug Administration.
194	FDA label for approved nitroglycerin from the official website of the U.S. Food and Drug Administration.
195	FDA label for approved dipyridamole from the official website of the U.S. Food and Drug Administration.
196	FDA label for approved acebutolol from the official website of the U.S. Food and Drug Administration.
197	FDA label for approved metolazone from the official website of the U.S. Food and Drug Administration.
198	FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
199	FDA label for approved nebivolol from the official website of the U.S. Food and Drug Administration.
200	FDA label for approved pentoxifylline from the official website of the U.S. Food and Drug Administration.
201	FDA label for approved methyldopa from the official website of the U.S. Food and Drug Administration.
202	FDA label for approved nicardipine from the official website of the U.S. Food and Drug Administration.
203	FDA label for approved bisoprolol from the official website of the U.S. Food and Drug Administration.
204	FDA label for approved isradipine from the official website of the U.S. Food and Drug Administration.
205	FDA label for approved mexiletine from the official website of the U.S. Food and Drug Administration.
206	FDA label for approved timolol from the official website of the U.S. Food and Drug Administration.
207	FDA label for approved quinapril from the official website of the U.S. Food and Drug Administration.
208	FDA label for approved dabigatran etexilate from the official website of the U.S. Food and Drug Administration.
209	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
210	FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
211	FDA label for approved chlorpheniramine from the official website of the U.S. Food and Drug Administration.
212	FDA label for approved promethazine from the official website of the U.S. Food and Drug Administration.
213	FDA label for approved loratadine from the official website of the U.S. Food and Drug Administration.
214	FDA label for approved cefdinir from the official website of the U.S. Food and Drug Administration.
215	FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
216	FDA label for approved cefadroxil from the official website of the U.S. Food and Drug Administration.
217	FDA label for approved budesonide from the official website of the U.S. Food and Drug Administration.
218	FDA label for approved levofloxacin from the official website of the U.S. Food and Drug Administration.
219	FDA label for approved salbutamol from the official website of the U.S. Food and Drug Administration.
220	FDA label for approved theophylline from the official website of the U.S. Food and Drug Administration.
221	FDA label for approved ivacaftor from the official website of the U.S. Food and Drug Administration.
222	FDA label for approved doxycycline from the official website of the U.S. Food and Drug Administration.
223	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
224	FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
225	FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
226	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
227	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
228	FDA label for approved ranitidine from the official website of the U.S. Food and Drug Administration.
229	FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
230	FDA label for approved loperamide from the official website of the U.S. Food and Drug Administration.
231	FDA label for approved dicyclomine from the official website of the U.S. Food and Drug Administration.
232	FDA label for approved ondansetron from the official website of the U.S. Food and Drug Administration.
233	FDA label for approved mycophenolate mofetil from the official website of the U.S. Food and Drug Administration.
234	FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
235	FDA label for approved tacrolimus from the official website of the U.S. Food and Drug Administration.
236	FDA label for approved ursodeoxycholic acid from the official website of the U.S. Food and Drug Administration.
237	FDA label for approved nizatidine from the official website of the U.S. Food and Drug Administration.
238	FDA label for approved mycophenolic acid from the official website of the U.S. Food and Drug Administration.
239	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
240	FDA label for approved trimethobenzamide from the official website of the U.S. Food and Drug Administration.
241	FDA label for approved dexlansoprazole from the official website of the U.S. Food and Drug Administration.
242	FDA label for approved balsalazide from the official website of the U.S. Food and Drug Administration.
243	FDA label for approved alosetron from the official website of the U.S. Food and Drug Administration.
244	FDA label for approved nitazoxanide from the official website of the U.S. Food and Drug Administration.
245	FDA label for approved rolapitant from the official website of the U.S. Food and Drug Administration.
246	FDA label for approved hydrochlorothiazide from the official website of the U.S. Food and Drug Administration.
247	FDA label for approved clindamycin from the official website of the U.S. Food and Drug Administration.
248	FDA label for approved isotretinoin from the official website of the U.S. Food and Drug Administration.
249	FDA label for approved acitretin from the official website of the U.S. Food and Drug Administration.
250	FDA label for approved tretinoin from the official website of the U.S. Food and Drug Administration.
251	FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
252	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
253	FDA label for approved celecoxib from the official website of the U.S. Food and Drug Administration.
254	FDA label for approved diclofenac from the official website of the U.S. Food and Drug Administration.
255	FDA label for approved etodolac from the official website of the U.S. Food and Drug Administration.
256	FDA label for approved meloxicam from the official website of the U.S. Food and Drug Administration.
257	FDA label for approved piroxicam from the official website of the U.S. Food and Drug Administration.
258	FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
259	FDA label for approved rifampicin from the official website of the U.S. Food and Drug Administration.
260	FDA label for approved conjugated estrogen from the official website of the U.S. Food and Drug Administration.
261	FDA label for approved risedronic acid from the official website of the U.S. Food and Drug Administration.
262	FDA label for approved diflunisal from the official website of the U.S. Food and Drug Administration.
263	FDA label for approved colchicine from the official website of the U.S. Food and Drug Administration.
264	FDA label for approved tolmetin from the official website of the U.S. Food and Drug Administration.
265	FDA label for approved lesinurad from the official website of the U.S. Food and Drug Administration.
266	FDA label for approved tofacitinib from the official website of the U.S. Food and Drug Administration.
267	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
268	FDA label for approved terazosin from the official website of the U.S. Food and Drug Administration.
269	FDA label for approved finasteride from the official website of the U.S. Food and Drug Administration.
270	FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
271	FDA label for approved tamsulosin from the official website of the U.S. Food and Drug Administration.
272	FDA label for approved nitrofurantoin from the official website of the U.S. Food and Drug Administration.
273	FDA label for approved tolterodine from the official website of the U.S. Food and Drug Administration.
274	FDA label for approved danazol from the official website of the U.S. Food and Drug Administration.
275	FDA label for approved mefenamic acid from the official website of the U.S. Food and Drug Administration.
276	FDA label for approved methenamine from the official website of the U.S. Food and Drug Administration.
277	FDA label for approved fesoterodine from the official website of the U.S. Food and Drug Administration.
278	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
279	FDA label for approved sildenafil from the official website of the U.S. Food and Drug Administration.
280	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
281	US patent application no. 8987474B2, Inhibition of Shp2/PTPN11 Protein Tyrosine Phosphatase by NSC-87877, NSC-117199 and Their Analogs.
282	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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