Details of the Drug Formulation (DFM)
General Information of DFM (ID: F07905) | |||||
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Name |
Felodipine 10 mg tablet
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Company |
AstraZeneca
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Active Pharmaceutical Ingredient (API) | Felodipine | API Info click to show the detail info of this API | |||
Essential hypertension | ICD-11: BA00 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E07QCK | DIG Info | Aluminum silicate | Adsorbent ... | ||
E0SJ4H | DIG Info | Beta-D-lactose | Diluent ... | ||
E09YYN | DIG Info | Eisenoxyd | Colorant | ||
E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
E0Q7IF | DIG Info | Povidone | Binding agent ... | ||
E0U9NK | DIG Info | Propyl gallate | Antimicrobial preservative ... | ||
E0RS6F | DIG Info | Sodium stearyl fumarate | lubricant | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: N1-methyl adenine demethylase (FTO) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 3 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | FTO_HUMAN | |||||
DBT Name: Arachidonate 5-lipoxygenase (ALOX5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 0.43 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | LOX5_HUMAN | |||||
DBT Name: Prostaglandin G/H synthase 2 (COX-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | IC50 = 7.2 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PGH2_HUMAN | |||||
DBT Name: Lysine-specific demethylase 4C (KDM4C) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 39 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | KDM4C_HUMAN | |||||
DBT Name: Tyrosine 3-monooxygenase (TH) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 1.9 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | TY3H_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | IC50 = 107 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Cation-dependent O-methyltransferase | ||||||
DBT Name: Catechol O-methyltransferase (COMT) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 0.015 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | COMT_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Phosphodiesterase 4D (PDE4D) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | IC50 = 26 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PDE4D_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | IC50 = 78.3 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Inhibition ratio = 29.6 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
Other protein families (OPF) | ||||||
DBT Name: Anthrax toxin receptor 2 (CMG-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | IC50 > 300000 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ANTR2_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Leukemia K562 cells (K562) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium stearyl fumarate | |||||
Biological Activity | IC50 = 20.2 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) | [6] | ||||
Structural Similarity | Tanimoto coefficient = 0.75 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0004 | |||||
DBT Name: Breast cancer MCF7 cells (MCF7) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium stearyl fumarate | |||||
Biological Activity | IC50 = 60 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) | [6] | ||||
Structural Similarity | Tanimoto coefficient = 0.75 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0031 | |||||
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