Details of the Drug Formulation (DFM)

General Information of DFM (ID: F20110)
Name
Simvastatin 20 mg tablet
Company
RemedyRepack
Active Pharmaceutical Ingredient (API) Simvastatin API Info click to show the detail info of this API
Dyslipidaemia ICD-11: 5C81 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0QV6C DIG Info Butylhydroxyanisole Antimicrobial preservative ...
E01VZR DIG Info Calcium ascorbate anhydrous Antioxidant
E09YYN DIG Info Eisenoxyd Colorant
E00DHW DIG Info Lactose monohydrate Binding agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      G-protein coupled receptor (GPCR)
            DBT Name: Alpha-2B adrenoceptor (ADA2B) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity EC50 = 0.5 nM (estimated based on the structural similarity with CHEMBL196 ) [1]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    UniProt ID ADA2B_HUMAN
            DBT Name: Muscarinic receptor M1 (ACM1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Butylhydroxyanisole
                    Biological Activity IC50 = 19 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ACM1_HUMAN
            DBT Name: Alpha-1A adrenoceptor (ADA1A) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Butylhydroxyanisole
                    Biological Activity IC50 = 19 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ADA1A_HUMAN
      Oxidoreductase (ORase)
            DBT Name: Catalase (CAT) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity EC50 = 1.37 ug.mL-1 (estimated based on the structural similarity with CHEMBL196 ) [3]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID CATA_RAT
            DBT Name: Prostaglandin G/H synthase 2 (COX-2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Butylhydroxyanisole
                    Biological Activity IC50 = 2.6 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PGH2_HUMAN
            DBT Name: Tyrosinase (TYR) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 = 32500 nM (estimated based on the structural similarity with CHEMBL196 ) [4]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    UniProt ID TYRO_HUMAN
      Nuclear receptor (NR)
            DBT Name: Progesterone receptor (PGR) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Butylhydroxyanisole
                    Biological Activity IC50 = 29 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PRGR_HUMAN
      Other protein families (OPF)
            DBT Name: Albumin (ALB) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 = 155380 nM (estimated based on the structural similarity with CHEMBL196 ) [5]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Bos taurus (Bovine)
                    UniProt ID ALBU_BOVIN
      Cell line (CELL)
            DBT Name: Lung cancer A-549 cells (A-549) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0023
            DBT Name: Ductal cancer CFPAC-1 cells (CFPAC-1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_1119
            DBT Name: Colon cancer HCT-116 cells (HCT-116) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0291
            DBT Name: Hepatoblastoma HepG2 cells (HepG2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0027
            DBT Name: Foreskin HFF fibroblasts (HFF) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_XB54
            DBT Name: Leukemia HL-60 cells (HL-60) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 = 10 nM (estimated based on the structural similarity with CHEMBL196 ) [7]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0002
            DBT Name: Breast cancer MCF7 cells (MCF7) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0031
            DBT Name: Colon cancer SW620 cells (SW620) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Calcium ascorbate anhydrous
                    Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [6]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0547
References
1 (-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata. Bioorg Med Chem. 2009 Mar 15; 17(6):2497-500.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine. Eur J Med Chem. 2010 Jan; 45(1):203-9.
4 Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorg Med Chem Lett. 2015 Apr 1; 25(7):1476-8.
5 Antidiabetic potential of phytochemicals isolated from the stem bark of Myristica fatua Houtt. var. magnifica (Bedd.) Sinclair. Bioorg Med Chem. 2018 Jul 23; 26(12):3461-3467.
6 Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives. Eur J Med Chem. 2019 Dec 15; 184:111739.
7 Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat Prod. 2009 Jun; 72(6):983-7.

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