General Information of DFM (ID: F23196)
Name	Ioflupane I-123 5mci/2.5ml solution
Company	Ge Hlthcare
Active Pharmaceutical Ingredient (API)	Ioflupane I-123		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E09EXY	DIG Info	Acetic acid	Acidulant ...
	E0SF4Y	DIG Info	Ethanol	Antimicrobial preservative ...
	E0VN9W	DIG Info	Sodium acetate	Antimicrobial preservative ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Free fatty acid receptor 2 (FFAR2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetic acid
Biological Activity	IC50 = 120000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	FFAR2_HUMAN
DBT Name: Free fatty acid receptor 3 (FFAR3)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetic acid
Biological Activity	EC50 = 12000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	FFAR3_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase I (CA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium acetate
Biological Activity	Ki = 10800 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH1_HUMAN
DBT Name: Carbonic anhydrase II (CA2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium acetate
Biological Activity	Ki = 130000 nM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH2_HUMAN

References
1	The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):493-8.
2	Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the Inside. J Med Chem. 2018 Jan 11; 61(1):47-61.
3	Carbonic anhydrase inhibitors. Inhibition of the -class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2521-6.
4	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.

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