Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23604)
Name
Adenosine 0.04% cream
Company
Bio-S Co. Ltd
Active Pharmaceutical Ingredient (API) Adenosine API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0FC7K DIG Info Cetyl ethylhexanoate Emollient
E0FY2S DIG Info Edetate disodium Complexing agent
E06WYP DIG Info Glycerin Antimicrobial preservative ...
E02ZUV DIG Info Hyaluronate sodium Humectant ...
E0I5TO DIG Info Phenoxyethanol Antimicrobial preservative
E0M1JK DIG Info Propylene glycol Antimicrobial preservative ...
E0HR5F DIG Info Soybean lecithin Other agent
E09WWS DIG Info Tocopheryl acetate Antioxidant
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Propylene glycol
                    Biological Activity Inhibition ratio < 20 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Soybean lecithin
                    Biological Activity IC50 = 6.61 mg.mL-1 (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Cell line (CELL)
            DBT Name: Fungoides HuT78 cells (HuT78) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hyaluronate sodium
                    Biological Activity EC50 = 41 ug.mL-1 (estimated based on the structural similarity with CHEMBL214326 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.92173913
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0337
            DBT Name: Prostate cancer LNCaP cells (LNCaP) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Tocopheryl acetate
                    Biological Activity EC50 = 38000 nM (estimated based on the structural similarity with CHEMBL242495 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.933333333
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0395
            DBT Name: Breast cancer MCF7 cells (MCF7) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Tocopheryl acetate
                    Biological Activity IC50 > 500000 nM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0031
            DBT Name: Leukemia MT4 cells (MT4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hyaluronate sodium
                    Biological Activity EC50 = 5.4 ug.mL-1 (estimated based on the structural similarity with CHEMBL214326 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.92173913
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_2632
References
1 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2 Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect. J Med Chem. 1993 Nov 12; 36(23):3546-55.
3 First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents. Bioorg Med Chem. 2007 May 15; 15(10):3413-21.
4 Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells. Bioorg Med Chem Lett. 1998 Sep 22; 8(18):2433-8.

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