Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23807)
Name
Leuprolide Acetate 1mg/0.2ml injectable
Company
Abbvie Endocrine
Active Pharmaceutical Ingredient (API) Leuprolide acetate API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E09EXY DIG Info Acetic acid Acidulant ...
E0NY1O DIG Info Benzyl alcohol Antimicrobial preservative ...
E0T4TW DIG Info Sodium chloride Diluent ...
E0L2PN DIG Info Sodium hydroxide Alkalizing agent
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      G-protein coupled receptor (GPCR)
            DBT Name: Free fatty acid receptor 2 (FFAR2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Acetic acid
                    Biological Activity IC50 = 120000 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID FFAR2_HUMAN
            DBT Name: Free fatty acid receptor 3 (FFAR3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Acetic acid
                    Biological Activity EC50 = 12000 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID FFAR3_HUMAN
      Oxidoreductase (ORase)
            DBT Name: Indoleamine 2,3-dioxygenase 1 (IDO1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzyl alcohol
                    Biological Activity IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.848101266
                    Tested Species Homo sapiens (Human)
                    UniProt ID I23O1_HUMAN
References
1 The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):493-8.
2 Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the Inside. J Med Chem. 2018 Jan 11; 61(1):47-61.
3 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.

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