General Information of DFM (ID: F24136)
Name	Rotigotine 2mg extended release film
Company	Ucb
Active Pharmaceutical Ingredient (API)	Rotigotine		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E00XLR	DIG Info	Ascorbyl palmitate	Antioxidant
	E0VX5C	DIG Info	DL-alpha-tocopherol	Antioxidant
	E0Q7IF	DIG Info	Povidone	Binding agent ...
	E03ORS	DIG Info	Silicone adhesive	Binding agent
	E0E9LJ	DIG Info	Sodium metabisulfite	Antimicrobial preservative ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Povidone
Biological Activity	IC50 = 107 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Povidone
Biological Activity	Protein expression upregulation (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Transferase (TFase)
DBT Name: Thiosulfate sulfurtransferase (TST)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Ascorbyl palmitate
Biological Activity	IC50 = 53000 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	THTR_HUMAN
Hydrolase (HDase)
DBT Name: Presenilin 1 (PSEN1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	DL-alpha-tocopherol
Biological Activity	EC50 > 100000 nM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	PSN1_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Povidone
Biological Activity	IC50 = 78.3 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN
DBT Name: Hsp60-Hsp10 complex (HSPD1-HSPE1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Ascorbyl palmitate
Biological Activity	IC50 = 3100 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	CH60_HUMAN ; CH10_HUMAN

References
1	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
3	HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1; 29(9):1106-1112.
4	Membrane anchoring -secretase modulators with terpene-derived moieties. Bioorg Med Chem Lett. 2013 Jul 1; 23(13):3852-6.

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