Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00624)
Name
Simethicone
Synonyms    Click to Show/Hide the Synonyms of This API
SIMETICONE; Phazyme; Antifoam A; DC antifoam A; Sentry Simethicone; Mylanta Gas Relief; Gas-X; Disflatyl; Mylicon Infant's Drops; Rioplus; Asidopan Plus; Wydrate Plus; Sab Simplex; Sentry Simethicone Emulsion; HSDB 3906; Simethicone [USAN:USP]; Silicone antifoam agent S 184; ANTIFOAM AF; Silicone antifoam emulsions SE 6 and SE 9; alpha-(Trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide; SCHEMBL339371; DB09512; FT-0674588; 24135-EP2305254A1; 24135-EP2314590A1; Q419415
Clinical Status
Approved
Disease Indication Irritable bowel syndrome ICD-11: DD91 [1]
PubChem CID
6433516
Formula
C6H18O4Si3
Canonical SMILES
CO[Si](C)(C)O[Si](C)(C)C.O=[Si]=O
InChI
1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;
InChIKey
AMTWCFIAVKBGOD-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6433516"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 238.46 Topological Polar Surface Area 52.6
XlogP N.A. Complexity 125
Heavy Atom Count 13 Rotatable Bond Count 3
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Simethicone 125 mg tablet Click to Show/Hide the Full List of Formulation(s):        25 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Isomalt; Maltodextrin; Sucralose; D&c red no. 27; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Adipic acid; Sucrose; Carboxymethylcellulose sodium; Silicon dioxide; Hydroxypropyl cellulose (type h); Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Infirst Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
Adipic acid DIG Info Organic anion transporter 1 (Ki = 407.38 nM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Isomalt DIG Info Colon cancer Caco-2 cells (EC50 = 99390 nM) [5]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Isomalt; Maltodextrin; Sucralose; D&c red no. 27; Magnesium stearate; Adipic acid; Sucrose; Carboxymethylcellulose sodium; Silicon dioxide; Hydroxypropyl cellulose (type h); Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Infirst Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
Adipic acid DIG Info Organic anion transporter 1 (Ki = 407.38 nM) [3]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
Isomalt DIG Info Colon cancer Caco-2 cells (EC50 = 99390 nM) [5]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; D&c red no. 27; Fd&c blue no. 1; Sorbitol; Propylene glycol; Talc; Triacetin; Silicon dioxide; Dextrates; Starch, corn; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company Boehringer Ingelheim Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [11]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Isomalt; Maltodextrin; Sucralose; Magnesium stearate; Sucrose; Carboxymethylcellulose sodium; Silicon dioxide; Hydroxypropyl cellulose (type h); Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Infirst Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
Isomalt DIG Info Colon cancer Caco-2 cells (EC50 = 99390 nM) [5]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Silicon dioxide; Cherry; Dextrates; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Silicon dioxide; Cherry; Dextrates; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Rite Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Silicon dioxide; Dextrates; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company SuperValu
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c yellow no. 6; Sorbitol; Talc; Medium-chain triglycerides; Silicon dioxide; Aluminum oxide; Dextrates; Starch, corn; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company Boehringer Ingelheim Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Silicon dioxide; Dextrates; Starch, corn; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Gericare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; D&c yellow no. 10; Maltodextrin; Propylene glycol; Silicon dioxide; Dextrose; Soy protein; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company Novartis Consumer Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [11]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; Maltodextrin; Sucralose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Dextrose; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; Maltodextrin; Sucralose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Dextrose; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company Target Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Kramer Novis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Maltodextrin; Sorbitol; Talc; Triacetin; Silicon dioxide; Dextrates; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Maltodextrin; Sorbitol; Talc; Triacetin; Silicon dioxide; Dextrates
                   Dosage Form Chewable Tablet
                   Company SuperValu
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Dextrates; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Army & Air Force Exchange Service
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Dextrates
                   Dosage Form Chewable Tablet
                   Company Greenbrier International
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; Fd&c red no. 40; D&c red no. 27; Sorbitol; Talc; Silicon dioxide; Cherry; Dextrates; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Family Dollar
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [4]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; D&c yellow no. 10; Maltodextrin; Magnesium stearate; Sorbitol; Cellulose, microcrystalline; Dextrose
                   Dosage Form Chewable Tablet
                   Company Safeway
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; Maltodextrin; Propylene glycol; Silicon dioxide; Dextrose, unspecified form; Soy protein; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company GlaxoSmithKline
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [11]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Sorbitol; Citric acid monohydrate; Talc; Silicon dioxide; Dextrates; Starch, corn; Tribasic calcium phosphate
                   Dosage Form Chewable Tablet
                   Company Boehringer Ingelheim Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fructose; Sorbitol; Silicon dioxide; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Gemini Pharmaceuticals; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 30; Maltodextrin; Magnesium stearate; Sorbitol; Sucrose; Cellulose, microcrystalline; Dextrose
                   Dosage Form Chewable Tablet
                   Company Health Mart; Leosons Overseas Corp; McKesson; Safeway; Select Brand; WinCo Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Sorbitol; Sucrose; Dextrose; Peppermint
                   Dosage Form Chewable Tablet
                   Company Advance Pharmaceutical; Qualitest Pharmaceuticals; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Sorbitol; Sucrose; Dextrose; Peppermint
                   Dosage Form Chewable Tablet
                   Company Reliable 1 Laboratires
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
          Simethicone 125 mg capsule Click to Show/Hide the Full List of Formulation(s):        27 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Mannitol; Sorbitol; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [12]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Mannitol; Sorbitol; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company H E B
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [12]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Mannitol; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company Softech Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [12]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Medium-chain triglycerides; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company BJWC (Berkley & Jensen / BJ's); CVS Pharmacy; Care One; Chain Drug Consortium; Chain Drug Marketing Association; Dolgencorp; Family Dollar; Fred's; KMART; Kroger; Major Pharmaceuticals; McKesson; Nash Finch Company; P & L Development; Preferred Plus; Safeway; SuperValu; Target Corporation; The Great Atlantic & Pacific Tea Company; TopCare; Valu Merchandisers Company; Walgreens Company; Walmart Stores; Western Family Foods; WinCo Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Medium-chain triglycerides; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company P & L Development
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company American Sales Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Amerisource Bergen; DZA Brands; Dolgencorp; H E B; Hy-Vee; L. Perrigo Company; Wakefern Food Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Humanwell PuraCap Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Water; Silicon dioxide; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company PuraVation Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Major Pharmaceuticals; Shopko
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company CVS Pharmacy; Care One; Chain Drug Marketing Association; Family Dollar; Fred's; Kroger; Meijer; P & L Development; TopCare; Valu Merchandisers Company; Walgreens Company; Walmart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company Chain Drug Marketing Association
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company Preferred Plus
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company AiPing Pharmaceutical; Allegiant Health; BJWC (Berkley & Jensen / BJ's); Care One; Chain Drug Consortium; Fred's; Kroger; McKesson; SuperValu; TopCare; Valu Merchandisers Company; Walmart Stores; Western Family Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin, unspecified; Hypromellose, unspecified; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company GlaxoSmithKline
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company Dolgencorp; McKesson; SuperValu
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
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Fd&c red no. 40; Fd&c blue no. 1; Sorbitol; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company McKesson; P & L Development
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Gelatin; Mineral oil; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Amerisource Bergen; Chain Drug Consortium; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Gelatin, unspecified; Mineral oil; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Better Living Brands
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Gelatin, unspecified; Mineral oil; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Harmon Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Titanium dioxide; Gelatin; Mineral oil; Peppermint oil
                   Dosage Form Oral Capsule
                   Company L.N.K. International; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Water; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company PuraCap Pharmaceutical; Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Water; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Humanwell PuraCap Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
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Mannitol; Sorbitol; Glycerin; Titanium dioxide; Water; Silicon dioxide; Gelatin; Peppermint oil; Sorbitan
                   Dosage Form Oral Capsule
                   Company Cardinal Health; Topco Associates
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [12]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
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D&c yellow no. 10; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Gelatin
                   Dosage Form Oral Capsule
                   Company Greenbrier International
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [9]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
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Fd&c blue no. 1; Fd&c yellow no. 5; Glycerin; Titanium dioxide; Water; Gelatin
                   Dosage Form Oral Capsule
                   Company Kareway Product; Navarro Discount Pharmacies; ProMex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [9]
             Drug Formulation 27 DFM Info click to show the detail info of this DFM
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Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Fd&c red no. 3; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Spirit Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [9]
          Simethicone 80 mg tablet Click to Show/Hide the Full List of Formulation(s):        14 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 30; Maltodextrin; Propylene glycol; Dextrose; Soy protein
                   Dosage Form Chewable Tablet
                   Company Novartis Consumer Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [11]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
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Stearic acid; Maltodextrin; Fructose; Sorbitol; Silicon dioxide; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Amvilab; Avera McKennan Hospital; Gemini Pharmaceuticals; Proficient Rx; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
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Calcium carbonate; Maltodextrin; Sucralose; Dextrose; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Valley Medical Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
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Stearic acid; Maltodextrin; Sorbitol; Sucrose; Dextrose; Peppermint
                   Dosage Form Chewable Tablet
                   Company A-S Medication Solutions; Advance Pharmaceutical; Aphena Pharma Solutions-Tennessee; Qualitest Pharmaceuticals; RemedyRepack; Richmond Pharmaceuticals; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sorbitol; Talc; Silicon dioxide; Dextrose; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Gericare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sorbitol; Talc; Silicon dioxide; Dextrose; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Rite Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Sorbitol; Sucrose; Dextrose; Peppermint
                   Dosage Form Chewable Tablet
                   Company Reliable 1 Laboratires
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sorbitol; Talc; Silicon dioxide; Peppermint; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sorbitol; Talc; Silicon dioxide; Dextrose; Tricalcium phosphate
                   Dosage Form Chewable Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Maltodextrin; Dextrose; Starch, corn
                   Dosage Form Chewable Tablet
                   Company Novartis Consumer Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Magnesium stearate; Sorbitol; Sucrose; Cellulose, microcrystalline; Dextrose
                   Dosage Form Chewable Tablet
                   Company Aidarex Pharmaceuticals; Aphena Pharma Solutions-Tennessee; Cardinal Health; Major Pharmaceuticals; McKesson; Valley Medical Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Magnesium stearate; Sorbitol; Cellulose, microcrystalline; Dextrose; Raw sugar
                   Dosage Form Chewable Tablet
                   Company GNP Gas Relief; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sorbitol; Stearyl stearate; Sucrose; Dextrose, unspecified form; Magnesium
                   Dosage Form Chewable Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [8]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Talc; Silicon dioxide; Dextrose
                   Dosage Form Chewable Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
          Simethicone 180 mg capsule Click to Show/Hide the Full List of Formulation(s):        11 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Mannitol; Sorbitol; Glycerin; Titanium dioxide; Water; Lecithin, soybean; Gelatin; Hypromelloses; Light mineral oil; Peppermint oil
                   Dosage Form Oral Capsule
                   Company GlaxoSmithKline
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [12]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [11]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c yellow no. 6; Glycerin; Silicon dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company American Sales Company; Cardinal Health; Kmart Corporation; Kroger Company; L Perrigo Company; Meijer; Publix Super Markets; Shopko; SuperValu; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Sorbitol; Glycerin; Titanium dioxide; Water; Hypromellose; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company Spirit Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [6]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Glycerin; Water; Silicon dioxide; Gelatin
                   Dosage Form Oral Capsule
                   Company Humanwell PuraCap Pharmaceutical; P & L Development
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c yellow no. 6; Glycerin; Gelatin
                   Dosage Form Oral Capsule
                   Company Softech Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Hypromelloses; Peppermint oil
                   Dosage Form Oral Capsule
                   Company We Care Distributor
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Sorbitol; Glycerin; Titanium dioxide; Water; Gelatin; Peppermint oil
                   Dosage Form Oral Capsule
                   Company AiPing Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Glycerin; Water; Gelatin
                   Dosage Form Oral Capsule
                   Company Amerisource Bergen; CVS Pharmacy; Chain Drug Consortium; Chain Drug Marketing Association; Dolgencorp; Fred's; Humanwell PuraCap Pharmaceutical; Major Pharmaceuticals; McKesson; Meijer; Preferred Plus; PuraCap Pharmaceutical; PuraVation Pharmaceuticals; Reliable 1 Laboratires; Rugby Laboratories; Safeway; SuperValu; The Great Atlantic & Pacific Tea Company; TopCare; Valu Merchandisers Company; Wal-Mart Stores; Walgreens Company; Walmart Stores; Western Family Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Glycerin; Water; Gelatin, unspecified
                   Dosage Form Oral Capsule
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Glycerin; Gelatin
                   Dosage Form Oral Capsule
                   Company C.B. Fleet Company; Medtech Products; Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Glycerin; Gelatin, unspecified
                   Dosage Form Oral Capsule
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
          Simethicone 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 33; Fd&c blue no. 1; Glycerin; Titanium dioxide; Water; Gelatin
                   Dosage Form Oral Capsule
                   Company C.B. Fleet Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 33; Fd&c blue no. 1; Glycerin; Water; Gelatin
                   Dosage Form Oral Capsule
                   Company CVS Pharmacy; Foodhold USA; Humanwell PuraCap Pharmaceutical; PuraCap Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Fd&c blue no. 1; Glycerin; Water; Gelatin
                   Dosage Form Oral Capsule
                   Company Humanwell PuraCap Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [9]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
References
1 FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
2 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
3 Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.
4 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
5 Novel natural compounds from endophytic fungi with anticancer activity. Eur J Med Chem. 2018 Aug 5; 156:316-343.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
7 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
8 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
9 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
10 PubChem BioAssay data set.
11 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
12 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
13 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.

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