Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0Z2FF)
DIG Name	Brushite
Synonyms	Click to Show/Hide the Synonyms of This DIG 7789-77-7; calcium hydrogenphosphate dihydrate; Calcium hydrogen phosphate dihydrate; Dicalcium phosphate dihydrate; Calcium monohydrogen phosphate dihydrate; UNII-O7TSZ97GEP; Dibasic calcium phosphate dihydrate; O7TSZ97GEP; Calcium phosphate, dibasic, dihydrate; D.C.P.; 14567-92-1; Phosphoric acid, calcium salt (1:1), dihydrate; Calcium phosphate dihydrate, dibasic; brushite; Aksepillen; Eunova; Calcium phosphate dibasic dihydrate; Calcium phosphate, dibasic dihydrate, 98+%, extra pure; Brushite (Ca(HPO4).2H2O); Calcium-hydrogenphosphat-2-wasser; Calster (TN); ACMC-20alil; CaH5O6P; CaHPO4.2H2O; Calcium phosphate dihydrate, dibasic [USP:JAN]; Calcium phosphate, gel (aged); CHEBI:4496; Dibasic calcium phosphate (TN); Dibasic calcium phosphate hydrate; DTXSID90872536; Calcium phosphate dibasic, hydrous; Calcium phosphate, dibasic, hydrous; calcium;hydrogen phosphate;dihydrate; MFCD00149621; AKOS015855298; DB14481; Calcium Hydrogenphosphate Dihydrate,(S); calcium hydrogenphosphate--water (1/2); Calcium hydrogenphosphate dihydrate, 98%; Dibasic calcium phosphate hydrate (JP17); Calcium phosphate, dihydrate, dibasic (USP); FT-0623398; D00937; Calcium hydrogenphosphate dihydrate, p.a., 98.0-105.0%; Calcium hydrogenphosphate dihydrate, Vetec(TM) reagent grade; UNII-97Z1WI3NDX component XAAHAAMILDNBPS-UHFFFAOYSA-L; Calcium phosphate dibasic dihydrate, puriss., meets analytical specification of Ph. Eur., BP, USP, 98-102.5%
DIG Function	Diluent
PubChem CID	104805
Formula	CaH5O6P
Canonical SMILES	O.O.OP(=O)([O-])[O-].[Ca+2]
InChI	1S/Ca.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+2;;;/p-2
InChIKey	XAAHAAMILDNBPS-UHFFFAOYSA-L
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=104805"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	172.09	Topological Polar Surface Area	85.4
	XlogP	N.A.	Complexity	46.5
	Heavy Atom Count	8	Rotatable Bond Count	0
	Hydrogen Bond Donor Count	3	Hydrogen Bond Acceptor Count	6

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[1]
Cefixime	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[2]
Pyrazinamide	API Info	Pulmonary tuberculosis [ICD-11: 1B10]		[3]
Hydroxychloroquine	API Info	Malaria [ICD-11: 1F40]		[4]
Piperazine	API Info	Ascariasis [ICD-11: 1F62]		[5]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Baclofen	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[6]
Megestrol acetate	API Info	Breast cancer [ICD-11: 2C60]		[7]
Vandetanib	API Info	Thyroid cancer [ICD-11: 2D10]		[8]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Levothroid	API Info	Hypothyroidism [ICD-11: 5A00]		[9]
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[10]
Phentermine	API Info	Obesity [ICD-11: 5B81]		[11]
Glyburide	API Info	Diabetes mellitus [ICD-11: 5A10]		[12]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[13]
Phendimetrazine	API Info	Obesity [ICD-11: 5B81]		[14]
Fludrocortisone	API Info	Hyponatraemia [ICD-11: 5C72]		[15]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Alprazolam	API Info	Anxiety disorder [ICD-11: 6B00]		[16]
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[17]
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[18]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[19]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[20]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[21]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[22]
Haloperidol	API Info	Schizophrenia [ICD-11: 6A20]		[23]
Fluphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[24]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[25]
Milnacipran	API Info	Asperger syndrome [ICD-11: 6A02]		[26]
Amoxapine	API Info	Major depressive disorder [ICD-11: 6A70]		[27]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Eszopiclone	API Info	Insomnia [ICD-11: 7A00]		[28]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[29]
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[30]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[31]
Memantine	API Info	Alzheimer disease [ICD-11: 8A20]		[32]
Sumatriptan	API Info	Migraine [ICD-11: 8A80]		[33]
Methadone	API Info	Anaesthesia [ICD-11: 8E22]		[34]
Ticagrelor	API Info	Cerebral stroke [ICD-11: 8B11]		[35]
Benztropine	API Info	Parkinsonism [ICD-11: 8A00]		[36]
Riluzole	API Info	Amyotrophic lateral sclerosis [ICD-11: 8B60]		[37]
Trihexyphenidyl	API Info	Parkinsonism [ICD-11: 8A00]		[38]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Methazolamide	API Info	Glaucoma [ICD-11: 9C61]		[39]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[40]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Lisinopril	API Info	Essential hypertension [ICD-11: BA00]		[41]
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[42]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[43]
Clonidine	API Info	Essential hypertension [ICD-11: BA00]		[44]
Caffeine	API Info	Orthostatic hypotension [ICD-11: BA21]		[45]
Amlodipine	API Info	Angina pectoris [ICD-11: BA40]		[46]
Spironolactone	API Info	Congestive heart failure [ICD-11: BD10]		[47]
Furosemide	API Info	Congestive heart failure [ICD-11: BD10]		[48]
Irbesartan	API Info	Essential hypertension [ICD-11: BA00]		[49]
Amiloride	API Info	Essential hypertension [ICD-11: BA00]		[50]
Mecamylamine	API Info	Essential hypertension [ICD-11: BA00]		[51]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Promethazine	API Info	Allergic rhinitis [ICD-11: CA08]		[52]
Desloratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[53]
Dexbrompheniramine	API Info	Allergic rhinitis [ICD-11: CA08]		[54]
Glycopyrrolate	API Info	Chronic obstructive pulmonary disease [ICD-11: CA22]		[55]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Bisacodyl	API Info	Irritable bowel syndrome [ICD-11: DD91]		[56]
Meclizine	API Info	Functional nausea/vomiting [ICD-11: DD90]		[57]
Loperamide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[58]
Dicyclomine	API Info	Irritable bowel syndrome [ICD-11: DD91]		[59]
Dimenhydrinate	API Info	Functional nausea/vomiting [ICD-11: DD90]		[60]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Hydrochlorothiazide	API Info	Luid retention [ICD-11: EF02]		[61]
Pseudoephedrine	API Info	Erythema multiforme [ICD-11: EB12]		[62]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[63]
Prednisone	API Info	Rheumatoid arthritis [ICD-11: FA20]		[64]
Flavoxate	API Info	Knee osteoarthritis [ICD-11: FA01]		[65]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Tolterodine	API Info	Overactive bladder [ICD-11: GC50]		[66]
Darifenacin	API Info	Overactive bladder [ICD-11: GC50]		[67]
Alfuzosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[68]
Trimethoprim	API Info	Infectious cystitis [ICD-11: GC00]		[69]
Mesna	API Info	Infectious cystitis [ICD-11: GC00]		[70]
ICD Disease Classification 17		Sexual health-related condition	Click to Show/Hide
Sildenafil	API Info	Erectile dysfunction [ICD-11: HA01]		[71]
ICD Disease Classification 18		Pregnancy/childbirth/puerperium condition	Click to Show/Hide
Doxylamine	API Info	Morning sickness [ICD-11: JA60]		[72]
ICD Disease Classification 20		Developmental anomaly	Click to Show/Hide
Estradiol	API Info	Turner syndrome [ICD-11: LD50]		[73]

References
1	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved cefixime from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved pyrazinamide from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved hydroxychloroquine from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved piperazine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved baclofen from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved megestrol acetate from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved vandetanib from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved levothroid from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved glyburide from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved phendimetrazine from the official website of the U.S. Food and Drug Administration.
15	Management of adrenal insufficiency in different clinical settings. Expert Opin Pharmacother. 2005 Nov;6(14):2407-17.
16	FDA label for approved alprazolam from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved haloperidol from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved fluphenazine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved milnacipran from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved amoxapine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved eszopiclone from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved memantine from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved methadone from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved ticagrelor from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved benztropine from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved riluzole from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved trihexyphenidyl from the official website of the U.S. Food and Drug Administration.
39	A repeated dose-response study of methazolamide in glaucoma. Arch Ophthalmol. 1978 Dec;96(12):2214-8.
40	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved lisinopril from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved clonidine from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved spironolactone from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved furosemide from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved irbesartan from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved amiloride from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved loxapine from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved promethazine from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved dexbrompheniramine from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved glycopyrrolate from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved meclizine from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved loperamide from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved dicyclomine from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved hydrochlorothiazide from the official website of the U.S. Food and Drug Administration.
62	A study of sustained action pseudoephedrine in allergic rhinitis. Ann Allergy. 1982 Feb;48(2):87-92.
63	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved prednisone from the official website of the U.S. Food and Drug Administration.
65	Agents for treatment of overactive bladder: a therapeutic class review. Proc (Bayl Univ Med Cent). 2007 Jul;20(3):307-14.
66	FDA label for approved tolterodine from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved darifenacin from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved alfuzosin from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved trimethoprim from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved mesna from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved sildenafil from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved doxylamine from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved estradiol from the official website of the U.S. Food and Drug Administration.

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