Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00149)
Name
Colchicine
Synonyms    Click to Show/Hide the Synonyms of This API
colchicine; 64-86-8; Colchicin; Colchicina; Colchisol; Condylon; Colcin; Colsaloid; Colchicinum; Colchineos; Colcrys; 7alphaH-Colchicine; Kolkicin; Goutnil; (S)-colchicine; Mitigare; spindle poison; NSC 757; UNII-SML2Y3J35T; N-Acetyl trimethylcolchicinic acid methylether; NSC757; CHEMBL107; SML2Y3J35T; CHEBI:27882; NSC-757; Colchicin [German]; NCGC00025125-07; MFCD00078484; Colchysat; Colchicina [Italian]; 7-alpha-H-Colchicine; DSSTox_CID_4845; DSSTox_RID_77551; DSSTox_GSID_24845; 30512-31-3; Colstat; Colchicine (TN); SMR000058323; CCRIS 691; Colchicine, Colchicum autumnale; 7.alpha.H-Colchicine; HSDB 3044; Colchicine [USP:JAN]; SR-01000075794; SR-01000597576; EINECS 200-598-5; AI3-31149; (S)-colchicina; (S)-colchicin; MPC-004; CAS-64-86-8; (-)-colchicine; Prestwick_695; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; Spectrum_000842; Tocris-1364; Prestwick0_000363; Prestwick1_000363; Prestwick2_000363; Prestwick3_000363; Spectrum2_000075; Spectrum3_000362; Spectrum4_000298; Spectrum5_000787; Colchicine (JP17/USP); UPCMLD-DP065; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; C 9754; EC 200-598-5; SCHEMBL8469; Lopac0_000310; methoxylated analogue of XD1; BSPBio_000485; BSPBio_002083; KBioGR_000856; KBioSS_001322; MLS001055448; MLS001304089; MLS002153786; DivK1c_000753; SPECTRUM1500205; SPBio_000289; SPBio_002406; BPBio1_000535; GTPL2367; MEGxp0_001879; DTXSID5024845; UPCMLD-DP065:001; ACon1_000353; HMS502F15; KBio1_000753; KBio2_001322; KBio2_003890; KBio2_006458; KBio3_001303; NINDS_000753; HMS1569I07; HMS1920A08; HMS2091G16; HMS2096I07; HMS2231C05; HMS3260N22; HMS3713I07; Pharmakon1600-01500205; ZINC621853; Colchicine, >=96.0% (HPLC); Tox21_110947; Tox21_201547; Tox21_300582; Tox21_500310; BDBM50014846; CCG-39910; KM0881; NSC756702; AKOS001582887; Colchicine, >=95% (HPLC), powder; Tox21_110947_1; CS-1141; DB08117; EBD2156734; LP00310; MCULE-1568647156; MCULE-7858118731; NSC-756702; SDCCGMLS-0066633.P001; SDCCGSBI-0050298.P006; IDI1_000753; NCGC00025125-01; NCGC00025125-02; NCGC00025125-03; NCGC00025125-04; NCGC00025125-05; NCGC00025125-06; NCGC00025125-08; NCGC00025125-09; NCGC00025125-10; NCGC00025125-11; NCGC00025125-12; NCGC00025125-13; NCGC00025125-14; NCGC00025125-15; NCGC00025125-18; NCGC00025125-20; NCGC00025125-33; NCGC00169157-01; NCGC00169157-02; NCGC00169157-03; NCGC00254359-01; NCGC00259096-01; NCGC00260995-01; AK167930; AS-13686; HY-16569; NCI60_041659; SBI-0050298.P004; EU-0100310; FT-0603187; MLS001055448-02; C-7100; C07592; D00570; J10109; M01514; 24218-EP2275412A1; 24218-EP2277865A1; 24218-EP2281815A1; 24218-EP2301933A1; 24218-EP2301940A1; 24218-EP2305219A1; 24218-EP2305640A2; 24218-EP2311827A1; 24218-EP2314590A1; binds to tubulin; inhibits microtubular assembly; 078C484; SR-01000075794-1; SR-01000075794-3; SR-01000075794-6; SR-01000075794-7; SR-01000597576-1; SR-01000597576-3; BRD-K00259736-001-06-5; BRD-K00259736-001-10-7; WLN: L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1; Benzo[a]heptalen-9(5H)-one,7-dihydro-1,2,3,10-tetramethoxy-; Colchicine, (European Pharmacopoeia (EP) Reference Standard); Colchicine, United States Pharmacopeia (USP) Reference Standard; Colchicine, BioReagent, plant cell culture tested, >=95% (HPLC); Colchicine, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
Disease Indication Uncontrolled gout ICD-11: FA25 [1]
PubChem CID
6167
Formula
C22H25NO6
Canonical SMILES
CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChIKey
IAKHMKGGTNLKSZ-INIZCTEOSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6167"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 399.4 Topological Polar Surface Area 83.1
XlogP 1 Complexity 740
Heavy Atom Count 29 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Colchicine 0.6 mg capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Water; Fd&c red no. 3; Silicon dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Bryant Ranch Prepack; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Titanium dioxide; Water; Fd&c red no. 3; Silicon dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Hikma Americas
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Colchicine 0.6 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Triacetin; Water; Alcohol; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Triacetin; Carnauba wax; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company AR Scientific; Aphena Pharma Solutions-Tennessee; Avera McKennan Hospital; Cardinal Health; Physicians Total Care; Prasco; Proficient Rx; RemedyRepack; Takeda Pharmaceuticals America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Triacetin; Carnauba wax; Hypromellose, unspecified; Microcrystalline cellulose; Polydextrose; Polyethylene glycol, unspecified; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Triacetin; Carnauba wax; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved colchicine from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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