Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00388) | |||||
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Name |
Meclofenamic acid
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Synonyms |
Click to Show/Hide the Synonyms of This API
meclofenamic acid; meclofenamate; 644-62-2; Meclophenamic acid; Arquel; Meclomen (free acid); 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid; Meclomen; Acido meclofenamico; INF 4668; Acide meclofenamique; Acidum meclofenamicum; Acide meclofenamique [INN-French]; Acido meclofenamico [INN-Spanish]; Acidum meclofenamicum [INN-Latin]; 2-(2,6-dichloro-3-methylanilino)benzoic acid; CI-583; N-(2,6-Dichloro-m-tolyl)anthranilic acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid; UNII-48I5LU4ZWD; INF-4668; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid; CHEMBL509; 48I5LU4ZWD; Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-; benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-; CHEBI:6710; 644-62-2 (free acid); CL-583; NSC-95309; MECLODIUM; 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid; Meclofenamic acid [USAN:INN:BAN]; CCRIS 5532; EINECS 211-419-5; NSC 95309; BRN 2221428; Meclofenamic acid (USAN/INN); Anthranilic acid, N-(2,6-dichloro-m-tolyl)-; CL 583; PubChem23443; Spectrum_000893; Prestwick0_000206; Prestwick1_000206; Prestwick2_000206; Prestwick3_000206; Spectrum2_001045; Spectrum3_000486; Spectrum4_000038; Spectrum5_000942; SCHEMBL106; Lopac0_000727; BSPBio_000191; BSPBio_001951; KBioGR_000475; KBioSS_001373; 2-(2,6-Dichloro-3-methylphenyl)aminobenzoic acid; DivK1c_000504; SPBio_000970; SPBio_002112; BPBio1_000211; GTPL7219; ZINC1655; DTXSID0048559; BDBM22971; KBio1_000504; KBio2_001373; KBio2_003941; KBio2_006509; KBio3_001451; NINDS_000504; NSC95309; AKOS012836983; Anthranilic acid,6-dichloro-m-tolyl)-; DB00939; QC-4386; SDCCGSBI-0050705.P005; IDI1_000504; NCGC00021132-01; ETHYL(2R,3R)-2,3-EPOXYBUTYRATE; SBI-0050705.P004; HY-117275; CS-0064844; FT-0610786; UNM000001246303; Benzoic acid,6-dichloro-3-methylphenyl)amino]-; C07117; D02341; 2-(2,6-dichloro-3-methylanilino)benzoic acid.; 2-(2,6-dichloro-3-methylphenylamino)benzoic acid; 644M622; Q2823284; W-104838; 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid; BRD-K50398167-236-02-9; BRD-K50398167-323-03-3
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Clinical Status |
Approved
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Disease Indication | Myalgia | ICD-11: FB56 | [1] | ||
PubChem CID | |||||
Formula |
C14H11Cl2NO2
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Canonical SMILES |
CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)O)Cl
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InChI |
1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
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InChIKey |
SBDNJUWAMKYJOX-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4037"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 296.1 | Topological Polar Surface Area | 49.3 | |
XlogP | 5.2 | Complexity | 327 | ||
Heavy Atom Count | 19 | Rotatable Bond Count | 3 | ||
Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 3 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Meclofenamic acid 100 mg capsule | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Cellulose, microcrystalline; Gelatin; Starch, corn
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Dosage Form | Oral Capsule | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [3] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Meclofenamic acid 50 mg capsule | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Cellulose, microcrystalline; Gelatin; Starch, corn
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Dosage Form | Oral Capsule | |||||
Company | Mylan Pharamceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [3] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [3] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
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