Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00587)
Name
Repaglinide
Synonyms    Click to Show/Hide the Synonyms of This API
Repaglinide; 135062-02-1; Prandin; NovoNorm; GlucoNorm; AG-EE 623 ZW; Repaglinidum [INN-Latin]; Repaglinida [INN-Spanish]; AG-EE 388 ZW; AGEE-623ZW; C27H36N2O4; UNII-668Z8C33LU; CHEMBL1272; AG-EE-388 ZW; CHEBI:8805; 668Z8C33LU; MFCD00906179; NCGC00016978-01; Repaglinida; Repaglinidum; CAS-135062-02-1; Actulin; Surepost; Reglin; SMR000466305; Prandin (TN); AG-EE 623ZW; Repaglinide (JAN/USP/INN); AG-EE-623 ZW; AG-EE-388; Repaglinide,(S); A10BX02; SMP-508; Surepost (TN); 135969-54-9; Repaglinide [USAN:USP:INN:BAN]; NN-623; 111GE012; Prestwick0_001046; Prestwick1_001046; Prestwick2_001046; Prestwick3_001046; DSSTox_CID_3552; DSSTox_RID_77078; DSSTox_GSID_23552; SCHEMBL16137; BSPBio_000972; MLS000759407; MLS001076684; MLS001424111; MLS006011560; AG-EE-623ZW; BIDD:GT0338; SPBio_002906; AG-EE-623-ZW; BPBio1_001070; GTPL6841; DTXSID3023552; HMS1571A14; HMS2051N08; HMS2094C07; HMS2098A14; HMS2231M21; HMS3414D09; HMS3678D09; HMS3715A14; Pharmakon1600-01506035; BCP04250; ZINC3798537; Tox21_110721; AC-726; ANW-63956; BDBM50153520; NSC759893; STK629501; AKOS005561792; Repaglinide, >=98% (HPLC), solid; BS-1010; CCG-101013; CS-0979; DB00912; MCULE-3611790330; NC00263; NSC-759893; NCGC00016978-02; NCGC00016978-04; NCGC00016978-05; HY-15209; SBI-0206942.P001; AB0013959; AB00514019; AM20090697; SW197344-4; 62R021; C07670; D00594; W-5210; AB00514019-09; AB00514019_10; AB00514019_11; SR-01000759404; Q-201663; Q2195995; SR-01000759404-4; BRD-K82846253-001-03-0; Z1777729210; Repaglinide, European Pharmacopoeia (EP) Reference Standard; Repaglinide, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Diabetes mellitus ICD-11: 5A10 [1]
PubChem CID
65981
Formula
C27H36N2O4
Canonical SMILES
CCOC1=C(C=CC(=C1)CC(=O)N[C@@H](CC(C)C)C2=CC=CC=C2N3CCCCC3)C(=O)O
InChI
1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
InChIKey
FAEKWTJYAYMJKF-QHCPKHFHSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=65981"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 452.6 Topological Polar Surface Area 78.9
XlogP 5.2 Complexity 619
Heavy Atom Count 33 Rotatable Bond Count 10
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Repaglinide 2 mg tablet Click to Show/Hide the Full List of Formulation(s):        11 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Butylated hydroxyanisole; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Polacrilin potassium; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Meglumine; Butylated hydroxyanisole; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide red; Glycerin; Poloxamer 407; Silicon dioxide; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide red; Glycerin; Poloxamer 188; Povidone; Cellulose, microcrystalline; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide red; Glycerin; Poloxamer 188; Povidone; Microcrystalline cellulose; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide red; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Poloxamer 181; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide red; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Poloxamer 181; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Gemini Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide red; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Poloxamer 181; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvKARE; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide red; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Poloxamer 181; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Gemini Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide yellow; Glycerin; Talc; Poloxamer 188; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide red; Poloxamer 407; Povidone k30; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Repaglinide 1 mg tablet Click to Show/Hide the Full List of Formulation(s):        11 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Butylated hydroxyanisole; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Polacrilin potassium; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Meglumine; Butylated hydroxyanisole; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide yellow; Glycerin; Poloxamer 407; Silicon dioxide; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide yellow; Glycerin; Poloxamer 188; Povidone; Cellulose, microcrystalline; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide yellow; Glycerin; Poloxamer 188; Povidone; Microcrystalline cellulose; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Ferric oxide yellow; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Poloxamer 181; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide yellow; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Poloxamer 181; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvKARE; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide yellow; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Poloxamer 181; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Gemini Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide yellow; Glycerin; Talc; Poloxamer 188; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Ferric oxide red; 1,2-dimyristoyl-sn-glycero-3-(phospho-rac-(1-glycerol)); Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Poloxamer 124; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide yellow; Poloxamer 407; Povidone k30; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Repaglinide 0.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Butylated hydroxyanisole; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Polacrilin potassium; Povidone, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Meglumine; Butylated hydroxyanisole; Croscarmellose sodium; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Glycerin; Poloxamer 407; Silicon dioxide; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Glycerin; Poloxamer 188; Povidone; Cellulose, microcrystalline; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Glycerin; Poloxamer 188; Povidone; Microcrystalline cellulose; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Anhydrous dibasic calcium phosphate; Glycerol formal; Povidone; Cellulose, microcrystalline; Polacrilin potassium; Poloxamer 124; Starch, corn
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Meglumine; Glycerin; Talc; Poloxamer 188; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Poloxamer 407; Povidone k30; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline; Polacrilin potassium
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical; Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved repaglinide from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Bioorg Med Chem. 2012 Jan 15; 20(2):641-9.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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