Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00879)
Name
Betamethasone
Synonyms    Click to Show/Hide the Synonyms of This API
betamethasone; 378-44-9; Betadexamethasone; Flubenisolone; Betamethazone; Rinderon; Visubeta; Betacorlan; Betacortril; Betamamallet; Betametasone; Betapredol; Betasolon; Betnelan; Betsolan; Celestene; Methazon; Becort; Bedifos; Cidoten; beta-Methasone; Desacort-Beta; Rinderon A; Celestone; beta-Methasone alcohol; Betametasona; Betamethasonum; Bebate; 9alpha-Fluoro-16beta-methylprednisolone; SCH 4831; Dermabet; 9-Fluoro-16beta-methylprednisolone; NSC-39470; SCH-4831; UNII-9842X06Q6M; Betafluorene; Betamethasone (Celestone); MFCD00062969; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione; Betamethasone cream; MLS000859943; CHEBI:3077; Betamethasone alcohol; Betametasone [DCIT]; NCS-39470; 9842X06Q6M; Betamethasone, 97%; (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; NCGC00164401-01; SMR000058601; Celestone Syrup and Tablets; Betametasona [INN-Spanish]; Betamethasonum [INN-Latin]; DSSTox_CID_2667; 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione; DSSTox_RID_76681; DSSTox_GSID_22667; (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)-; .beta.-Methasone; 9-Fluoro-16.beta.-methylprednisolone; 9a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione; (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; Rinderon (TN); (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one.; .beta.-Methasone alcohol; 9.alpha.-Fluoro-16.beta.-methylprednisolone; 9-alpha-Fluoro-16-beta-methylprednisolone; HSDB 3015; EINECS 206-825-4; NSC 39470; Prednisolone, 9-fluoro-16beta-methyl-; BRN 3176546; NSC39470; Desacort-.beta.; .beta.-Corlan; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione; NCGC00091019-08; CAS-378-44-9; Prestwick_703; Prednisolone, 9-fluoro-16.beta.-methyl-; 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-; Betamethasone, topical; Betamethasone [USAN:USP:INN:BAN:JAN]; Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16beta-methyl-; Betamethasone, >=98%; Prestwick0_000362; Prestwick1_000362; Prestwick2_000362; Prestwick3_000362; CHEMBL632; EC 206-825-4; cid_9782; SCHEMBL4565; 16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione; 9-alpha-Fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-; BIDD:PXR0047; BSPBio_000483; 4-08-00-03501 (Beilstein Handbook Reference); MLS001066413; MLS001332616; MLS002153244; SPBio_002404; Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16.beta.-methyl-; BPBio1_000533; GTPL7061; DTXSID3022667; BDBM73823; Betamethasone (JP17/USP/INN); BCPP000345; HMS1569I05; HMS2096I05; HMS2233I08; HMS3713I05; BCP02020; ZINC3876136; Tox21_112115; Tox21_301455; s1500; AKOS008901360; AKOS015894863; Tox21_112115_1; ACN-043339; BCP9000393; CCG-220362; CS-1897; DB00443; EBD2157848; KS-5302; 9-Fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione; SMP1_000043; Betamethasone Dipropionate EP Impurity A; NCGC00164401-02; NCGC00164401-03; NCGC00255195-01; HY-13570; AB0012192; Betamethasone 100 microg/mL in Acetonitrile; D1961; Betamethasone, meets USP testing specifications; C06848; D00244; 20525-EP2272832A1; 20525-EP2295409A1; 20525-EP2298778A1; 20525-EP2308562A2; 20525-EP2314585A1; 20525-EP2314590A1; 20525-EP2371811A2; 378M449; Betamethasone, VETRANAL(TM), analytical standard; Q416132; SR-01000780582; SR-01000780582-2; W-106509; BRD-K39188321-001-03-9; Betamethasone, British Pharmacopoeia (BP) Reference Standard; Betamethasone, European Pharmacopoeia (EP) Reference Standard; Betamethasone, pharmaceutical impurity standard, >=95.0% (HPLC); Betamethasone, United States Pharmacopeia (USP) Reference Standard; (11.beta.,16.beta.)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-.alpha.-Fluoro-11-.beta.,17,21-trihydroxy-16-.beta.-methylpregna-1,4-diene-3,20-dione; 9-alpha-Fluor-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-dien-3,20-dion; 9-fluoro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16beta-methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione; Betamethasone, Pharmaceutical Secondary Standard; Certified Reference Material; Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methyl-; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl- (8CI); Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-; (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one; 16-.beta.-Methyl-1,4-pregnadiene-9-.alpha.-fluoro-11-.beta.,17-.alpha.,21-triol-3,20-dione; 9-.alpha.-Fluoro-11-.beta.,17-.alpha.,21-trihydroxy-16-.beta.-methylpregna-1,4-diene-3,20-dione; 9-.alpha.-Fluoro-16-.beta.-methyl-1,4-pregnadiene-11-.beta.,17-.alpha.,21-triol-3,20-dione; 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, (11.beta.,16.beta.) #; Betamethasone; 9-Fluoro-11?,17,21-trihydroxy-16?-methylpregna-1,4-diene-3,20-dione; (11?,16?)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9?-Fluoro-16?-methylprednisolone
Clinical Status
Approved
PubChem CID
9782
Formula
C22H29FO5
Canonical SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
InChIKey
UREBDLICKHMUKA-DVTGEIKXSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=9782"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 392.5 Topological Polar Surface Area 94.8
XlogP 1.9 Complexity 805
Heavy Atom Count 28 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Betamethasone Valerate 0.1% cream Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Water; Mineral Oil; Sodium Phosphate, Monobasic; Petrolatum; Polyethylene Glycol 1000; Ceteareth-15; Stearyl Alcohol; Cetyl Alcohol; Propylene Glycol; Phosphoric Acid; Chlorocresol
                   Dosage Form Cream
                   Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Chlorocresol DIG Info Serotonin receptor 2B (IC50 = 1856 nM) [1]
Phosphoric acid DIG Info Carbonic anhydrase IV (Ki = 9800 nM) [2]
Cetyl alcohol DIG Info Breast cancer FM3A cells (EC50 = 1600 nM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polyethylene glycol 1000 DIG Info Cytochrome P450 2E1 (IC50 = 75.3 uM) [5]
          Betamethasone 0.05% cream Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Water; Mineral Oil; Petrolatum; Polyoxyl 20 Cetostearyl Ether; Cetyl Alcohol; Stearyl Alcohol; Sodium Phosphate, Monobasic, Unspecified Form; Chlorocresol; Sodium Hydroxide; Phosphoric Acid
                   Dosage Form Cream
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Chlorocresol DIG Info Serotonin receptor 2B (IC50 = 1856 nM) [1]
Phosphoric acid DIG Info Carbonic anhydrase IV (Ki = 9800 nM) [2]
Cetyl alcohol DIG Info Breast cancer FM3A cells (EC50 = 1600 nM) [3]
Polyoxyl 20 cetyl ether DIG Info Cholesterol 25-hydroxylase (EC50 = 211.5 uM) [5]
          Betamethasone Valerate 0.12% aerosol Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cetyl Alcohol; Anhydrous Citric Acid; Alcohol; Polysorbate 60; Potassium Citrate; Propylene Glycol; Water; Stearyl Alcohol; Propane; Butane
                   Dosage Form Aerosol
                   Company Ingenus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [6]
Cetyl alcohol DIG Info Breast cancer FM3A cells (EC50 = 1600 nM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
          Betamethasone 0.05% ointment Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Carbomer Homopolymer Type C; Ceteareth-30; Chlorocresol; Cyclomethicone; Propylene Glycol; Water; Sodium Hydroxide; Sorbitol; Petrolatum; White Wax
                   Dosage Form Ointment
                   Company Preferred Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Chlorocresol DIG Info Serotonin receptor 2B (IC50 = 1856 nM) [1]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Propylene Glycol; Propylene Glycol Monostearate; White Wax; Petrolatum
                   Dosage Form Ointment
                   Company E. Fougera & Co. A Division Of Fougera Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Propylene glycol monostearate DIG Info Multidrug resistance protein 1 (Inhibition ratio = 25 %) [7]
References
1 DrugMatrix in vitro pharmacology data.
2 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5763-7.
3 Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes. J Med Chem. 2002 Mar 14; 45(6):1374-8.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
6 PubChem BioAssay data set.
7 Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int J Pharm. 2006 Apr 26;313(1-2):49-56.

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