Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0D4QT)
DIG Name	Polyethylene glycol 1000
DIG Function	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Linezolid	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[1]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Nicotinic acid	API Info	Lung cancer [ICD-11: 2C25]		[2]
Capecitabine	API Info	Colon cancer [ICD-11: 2B90]		[3]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[4]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[5]
Potassium chloride	API Info	Hypokalemia [ICD-11: 5C77]		[6]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[7]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[8]
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[9]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[10]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Zolpidem	API Info	Insomnia [ICD-11: 7A00]		[11]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[12]
Tramadol	API Info	Anaesthesia [ICD-11: 8E22]		[13]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[14]
Zolmitriptan	API Info	Migraine [ICD-11: 8A80]		[15]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[16]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[17]
Caffeine	API Info	Orthostatic hypotension [ICD-11: BA21]		[18]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Naproxen	API Info	Rheumatoid arthritis [ICD-11: FA20]		[19]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[20]
Phenazopyridine	API Info	Infectious cystitis [ICD-11: GC00]		[21]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio < 60 % (tested by experiment)		[22]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
DBT Name: Cytochrome P450 2E1 (CYP2E1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 75.3 uM (tested by experiment)		[23]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 365.6 uM (tested by experiment)		[23]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 139 uM (tested by experiment)		[23]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2CJ_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 409.6 uM (tested by experiment)		[23]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN
DBT Name: Cytochrome P450 3A5 (CYP3A5)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 78 uM (tested by experiment)		[23]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A5_HUMAN

References
1	FDA label for approved linezolid from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved nicotinic acid from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved capecitabine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved potassium chloride from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved zolpidem from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved zolmitriptan from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved phenazopyridine from the official website of the U.S. Food and Drug Administration.
22	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
23	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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