Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01182)
Name
Isoproterenol
Synonyms    Click to Show/Hide the Synonyms of This API
isoproterenol; Isoprenaline; Isoprenalin; Norisodrine; Novodrin; Isopropydrin; 7683-59-2; Isopropylarterenol; Asiprenol; Assiprenol; Bellasthman; Respifral; Aludrin; Aludrine; Asmalar; Isadrine; N-Isopropylnoradrenaline; Bronkephrine; Isonorene; Isopropyladrenaline; Lomupren; Neodrenal; Proternol; N-Isopropylnorepinephrine; Isopropylnorepinephrine; neo-Epinine; Isonorin; Isorenin; Saventrine; Isopropylnoradrenaline; Isopropyl noradrenaline; Racemic isoprenaline; dl-Isadrine; Racemic isoproterenol; (+-)-Isoproterenol; Vapo-N-iso; Epinephrine isopropyl homolog; Isoprenalinum; Aleudrine; Isupren; (+-)-Isoprenaline; Isoprenalina; Dihydroxyphenylethanolisopropylamine; WIN 5162; 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol; 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol; ICI 46399; Medihaler-ISO; 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol; alpha-(Isopropylaminomethyl)protocatechuyl alcohol; N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine; Aleudrin; Isoprenaline (INN); 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol; 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-; CHEMBL434; 3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol; Isoproterenolum; CHEBI:64317; 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-; Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol; 7683-59-2 (free); NSC-9975; NSC33791; Isoprenaline [INN]; NSC-33791; 3,4-dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol; NCGC00015558-06; 3,4-Dihydroxy-.alpha.-(isopropylaminomethyl)-benzyl alcohol; 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol; Isoproterenol [JAN]; Protocatechuyl alcohol,-; DSSTox_CID_3175; DL(+-)-Isoproterenol; L-Isoproterenol; Levisoprenaline; Proternol L; DSSTox_RID_76904; DSSTox_GSID_23175; Isoprenalinum [INN-Latin]; .alpha.-(Isopropylaminomoethyl)protocatechuyl alcohol; Isoprenalina [INN-Spanish]; 4-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol; Isoproterenol Chloride; WLN: QR BQ DYQ1MY1&1; 3,4-Dihydroxy-.alpha.-[(isopropylamino)methyl]benzyl alcohol; 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol; 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol; CAS-7683-59-2; ISOPROP; CCRIS 3081; NSC 9975; 1, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-; EINECS 231-687-7; NSC 33791; Isopropylaminomethyl-3,4-dihydroxyphenyl carbinol; 4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol; BRN 2213857; 4-{1-hydroxy-2-[(methylethyl)amino]ethyl}benzene-1,2-diol; Benzyl alcohol,4-dihydroxy-.alpha.-[(isopropylamino)methyl]-; Isoproterenol-l; Isoproterenol;; Isoproterenol (-); Isoproterenol,(+); Protocatechuyl alcohol, alpha-(isopropylaminomethyl)-; ISOPROTERONOL; Isoproterenol dl-form; Isuprel (Salt/Mix); Izadrin (Salt/Mix); Euspiran (Salt/Mix); (+/-)-isoprenaline; (+/-)-isoproterenol; Spectrum_000949; 114-45-4; Prestwick0_001097; Prestwick1_001097; Prestwick2_001097; Spectrum2_001061; Spectrum3_000474; Spectrum4_000024; Spectrum5_000880; (.+/-.)-Isoprenaline; (.+/-.)-Isoproterenol; SCHEMBL4165; DL(.+/-.)-Isoproterenol; Lopac0_000711; Oprea1_009434; BSPBio_002208; GTPL536; KBioGR_000427; KBioSS_001429; 3-13-00-02387 (Beilstein Handbook Reference); DivK1c_000894; SPBio_001042; SPBio_003057; SGCUT00015; 4-(1-Hydroxy-2(isopropylamino)ethyl)-benzene 1,2-diol; DTXSID4023175; BDBM25392; KBio1_000894; KBio2_001429; KBio2_003997; KBio2_006565; KBio3_001428; NSC9975; NINDS_000894; HMS2089A12; HMS3742A11; BCP09043; Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-; to_000062; (A+/-)-Isoproterenol hydrochloride; Tox21_110172; PDSP1_001425; PDSP2_001409; SBB005855; STL558077; AKOS015913894; Tox21_110172_1; CCG-204727; CCG-204796; DB01064; MCULE-6061231962; SDCCGSBI-0050620.P003; SDCCGSBI-0050689.P005; IDI1_000894; NCGC00015558-04; NCGC00015558-05; NCGC00015558-07; NCGC00015558-08; NCGC00015558-09; NCGC00015558-10; NCGC00015558-11; NCGC00015558-12; NCGC00015558-14; NCGC00015558-25; NCGC00016665-02; NCGC00025274-03; NCGC00025274-04; NCGC00162220-01; A-21; ST077771; SBI-0050689.P004; FT-0724367; C07056; D08090; AB00053487-09; AB00053487-10; AB00053487_11; AB00053487_12; 683I592; AG-219/03618046; L000936; Q415550; .alpha.-(Isopropylaminomethyl)protocatechuyl alcohol; Protocatechuyl alcohol,.alpha.-(isopropylamino-methyl),-; 3,4-dihydroxy-alpha-[(isopropylamino)methyl]-benzyl alcohol; 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol #; N-Isopropyl-.beta.-dihydroxyphenyl-.beta.-hydroxyethylamine; 4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;hydrochloride; 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol, 2; Benzyl alcohol, 3,4-dihydroxy-.alpha.-((isopropylamino)methyl)-; 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- (9CI)
Clinical Status
Approved
PubChem CID
3779
Formula
C11H17NO3
Canonical SMILES
CC(C)NCC(C1=CC(=C(C=C1)O)O)O
InChI
1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
InChIKey
JWZZKOKVBUJMES-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3779"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 211.26 Topological Polar Surface Area 72.7
XlogP -0.6 Complexity 187
Heavy Atom Count 15 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Isoproterenol 1mg/5ml solution Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous Citric Acid; Edetate Disodium; Hydrochloric Acid; Sodium Chloride; Sodium Hydroxide; Trisodium Citrate Dihydrate; Water
                   Dosage Form Solution
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [1]
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Edetate Disodium; Sodium Chloride; Trisodium Citrate Dihydrate; Anhydrous Citric Acid; Water; Hydrochloric Acid; Sodium Hydroxide
                   Dosage Form Solution
                   Company Auromedics Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [1]
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Citrate; Citric Acid Acetate; Hydrochloric Acid; Sodium Hydroxide; Water; ; Nitrogen; Edetate Disodium; Sodium Chloride
                   Dosage Form Solution
                   Company Cipla Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [3]
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [2]
References
1 PubChem BioAssay data set.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.
3 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.

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