Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01198)
Name	Lasmiditan
Synonyms	Click to Show/Hide the Synonyms of This API Lasmiditan; 439239-90-4; 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide; COL-144; lasmitidan; UNII-760I9WM792; LY573144; 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide; 439239-90-4 (free base); 760I9WM792; 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide; Lasmiditan [USAN:INN]; Reyvow; COL 144; Lasmiditan (USAN/INN); SCHEMBL536057; GTPL3928; CHEMBL3039520; DTXSID40469435; QCR-219; AMY27880; BCP04734; EX-A1300; EX-A1653; ZINC3818355; 6063AB; MFCD18633238; AKOS016000352; BCP9000841; CS-2032; DB11732; Lasmiditan; OL-144; LY573144; SB19007; Lasmiditan (COL-144; LY573144); AS-35247; HY-14861; BCP0726000027; AB0094858; A14198; D10338; L022410; Q6493750; 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide; 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide; 2,4,6-trifluoro-N-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide; Benzamide, 2,4,6-trifluoro-N-(6-((1-methyl-4-piperidinyl)carbonyl)-2-pyridinyl)-
Clinical Status	Approved
PubChem CID	11610526
Formula	C19H18F3N3O2
Canonical SMILES	CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F
InChI	1S/C19H18F3N3O2/c1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22/h2-4,9-11H,5-8H2,1H3,(H,23,24,27)
InChIKey	XEDHVZKDSYZQBF-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11610526"></iframe>
Structure	3D MOL is unavailable		2D MOL
Physicochemical Properties	Molecular Weight	377.4	Topological Polar Surface Area	62.3
	XlogP	2.8	Complexity	530
	Heavy Atom Count	27	Rotatable Bond Count	4
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	7

Full List of Drug Formulations (DFMs) Containing This API
Lasmiditan 100 mg tablet			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Croscarmellose Sodium; Magnesium Stearate; Microcrystalline Cellulose; Pregelatinized Starch; Sodium Lauryl Sulfate; Black Ferric Oxide; Polyethylene Glycol; Polyvinyl Alcohol; Red Ferric Oxide; Talc; Titanium Dioxide
Dosage Form	Tablet
Company	Eli Lilly And
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[1]
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[3]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[3]
	Polyethylene glycol 4000	DIG Info	Albendazole monooxygenase (Inhibition ratio < 40 %)	[4]
	Pregelatinized starch	DIG Info	Multidrug resistance protein 1 (Protein expression downregulation)	[3]
Lasmiditan 50 mg tablet			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Croscarmellose Sodium; Magnesium Stearate; Microcrystalline Cellulose; Pregelatinized Starch; Sodium Lauryl Sulfate; Black Ferric Oxide; Polyethylene Glycol; Polyvinyl Alcohol; Talc; Titanium Dioxide
Dosage Form	Tablet
Company	Eli Lilly And
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[1]
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[3]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[3]
	Polyethylene glycol 4000	DIG Info	Albendazole monooxygenase (Inhibition ratio < 40 %)	[4]
	Pregelatinized starch	DIG Info	Multidrug resistance protein 1 (Protein expression downregulation)	[3]
Lasmiditan 200 mg tablet			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Croscarmellose Sodium; Magnesium Stearate; Microcrystalline Cellulose; Pregelatinized Starch; Sodium Lauryl Sulfate; Black Ferric Oxide; Polyethylene Glycol; Polyvinyl Alcohol; Talc; Titanium Dioxide
Dosage Form	Tablet
Company	Eli Lilly And
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[1]
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[3]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[3]
	Polyethylene glycol 4000	DIG Info	Albendazole monooxygenase (Inhibition ratio < 40 %)	[4]
	Pregelatinized starch	DIG Info	Multidrug resistance protein 1 (Protein expression downregulation)	[3]

References
1	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
2	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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