General Information of API (ID: D00161)
Name
Cysteamine
Synonyms    Click to Show/Hide the Synonyms of This API
CYSTEAMINE; 2-Aminoethanethiol; Mercaptamine; 60-23-1; Thioethanolamine; Becaptan; Mercamine; Cysteinamine; beta-Mercaptoethylamine; 2-Mercaptoethylamine; Cysteamin; Lambraten; Lambratene; beta-Aminoethanethiol; Cystagon; Riacon; Decarboxycysteine; Mercaptoethylamine; 2-Amino-1-ethanethiol; Ethanethiol, 2-amino-; Cisteamina; 2-Aminoethyl mercaptan; beta-Aminoethylthiol; 2-Mercaptoethanamine; Mercaptamin; (2-Mercaptoethyl)amine; MEA (mercaptan); Ethanethiolamine; 2-AMINO-ETHANETHIOL; beta-MEA; Aminoethyl mercaptan; Mercaptamina; Mercaptaminum; Cysteamide; Mecramine; Mercamin; Merkamin; Cisteamina [Italian]; Cystaran; Mercaptaminum [INN-Latin]; Mercaptamina [INN-Spanish]; 1-Amino-2-mercaptoethylamine; L-1573; Cysteamine (USAN); WR 347; 2-aminoethane-1-thiol; UNII-5UX2SD1KE2; NSC 647528; Cysteamine [USAN]; Mercaptamine (INN); .beta.-Mercaptoethylamine; 5UX2SD1KE2; CHEBI:17141; 2-aminoethane-1-thiol; Cysteamine; Mercaptamine [INN]; NSC647528; NSC-647528; NCGC00015691-03; 2-Aminoethanethiol, 95%; Cysteamine [USAN:BAN]; beta-Mercaptoethylamine;2-Aminoethanethiol;2-Mercaptoethylamine; C2H7NS; Cysteamine bitartate; CCRIS 3083; HSDB 7353; EINECS 200-463-0; L 1573; Cystagone; b-Aminoethylthiol; 2-aminoethanethio; b-Aminoethanethiol; mercapto ethylamine; b-Mercaptoethylamine; MFCD00008196; 2-amino-ethyl thiol; .beta.-MEA; Cysteamine, ~95%; Cysteamine, free base; .beta.-Aminoethylthiol; Spectrum_001755; .beta.-Aminoethanethiol; ACMC-1AVBC; SpecPlus_000654; (Mercaptoethyl)ammonium toluene-p-sulphonate; Lopac-M-6500; DSSTox_CID_2875; bmse000388; CHEMBL602; C-9500; DSSTox_RID_76770; DSSTox_GSID_22875; KBioSS_002235; DivK1c_006750; 2-$l^{1}-sulfanylethanamine; BDBM7968; GTPL7440; 2,3-DESHYDROLANTHIONINE; DTXSID3022875; KBio1_001694; KBio2_002235; KBio2_004803; KBio2_007371; Cysteamine, >=98.0% (RT); BCP15015; ZINC8034121; EINECS 221-235-7; Tox21_113092; ANW-33452; HY-77591A; STK315355; AKOS003793343; CCG-204834; DB00847; MCULE-1838427828; NE18622; SDCCGSBI-0050727.P004; CAS-60-23-1; NCGC00015691-01; NCGC00015691-02; NCGC00015691-04; NCGC00015691-14; NCGC00162236-01; NCGC00162236-02; AS-56218; BP-13401; NCI60_002000; SBI-0050727.P003; AB0020070; DB-053562; FT-0611243; C01678; D03634; AB00053754_09; AB00053754_10; 106791-EP2292597A1; 106791-EP2295407A1; 106791-EP2298736A1; 213515-EP2371809A1; Cysteamine, 2-Mercaptoethylamine, Thioethanolamine; Q617563; F0001-1576; 2DFDA1F8-7010-4225-8280-AB1C4C43F546
Clinical Status
Approved
Disease Indication Nephropathic cystinosis ICD-11: 5C60 [1]
PubChem CID
6058
Formula
C2H7NS
Canonical SMILES
C(CS)N
InChI
1S/C2H7NS/c3-1-2-4/h4H,1-3H2
InChIKey
UFULAYFCSOUIOV-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6058"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 77.15 Topological Polar Surface Area 27
XlogP -0.4 Complexity 10
Heavy Atom Count 4 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Cysteamine 150 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Ammonia; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Gelatin, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Cysteamine 50 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Ammonia; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Gelatin, unspecified; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Cysteamine 25 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 2; Talc; Titanium dioxide; Triethyl citrate; Water; Cellulose, microcrystalline; Gelatin; Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a
                   Dosage Form Delayed Release Oral Capsule
                   Company Raptor Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [5]
          Cysteamine 75 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 2; Talc; Titanium dioxide; Triethyl citrate; Water; Cellulose, microcrystalline; Gelatin; Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a
                   Dosage Form Delayed Release Oral Capsule
                   Company Raptor Therapeutics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [5]
          Cysteamine Bitartrate eq 50mg base capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ammonium Hydroxide; Black Iron Oxide; Colloidal Silicon Dioxide; Croscarmellose Sodium; Gelatin; Magnesium Stearate; Microcrystalline Cellulose; Pharmaceutical Glaze; Pregelatinized Starch; Propylene Glycol; Sodium Lauryl Sulfate; Titanium Dioxide
                   Dosage Form Capsule
                   Company Mylan Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [4]
          Cysteamine Bitartrate eq 75mg base capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Gelatin; Ink (Blue And White); Titanium Dioxide
                   Dosage Form Capsule
                   Company Horizon Therapeutics Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [6]
References
1 FDA label for approved cysteamine from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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