General Information of DFM (ID: F08264)
Name
Flavoxate 100 mg tablet
Company
Carilion Materials Management; Paddock Laboratories,
Active Pharmaceutical Ingredient (API) Flavoxate API Info click to show the detail info of this API
Knee osteoarthritis ICD-11: FA01 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0MF5O DIG Info Ethyl acrylate Film/membrane-forming agent ...
E00DHW DIG Info Lactose monohydrate Binding agent ...
E01UTP DIG Info Magnesium stearate lubricant
E0XX6I DIG Info Methyl methacrylate Film/membrane-forming agent
E01UTV DIG Info Silicon dioxide Anticaking agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Magnesium stearate
                    Biological Activity Protein expression downregulation (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Silicon dioxide
                    Biological Activity Protein expression downregulation (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Other protein families (OPF)
            DBT Name: NFE2-related factor 2 (NRF2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Ethyl acrylate
                    Biological Activity EC50 = 5110 nM (estimated based on the structural similarity with CHEMBL2107333 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.837837838
                    Tested Species Homo sapiens (Human)
                    UniProt ID NF2L2_HUMAN
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2 A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1; 185:111777.

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