Details of the Drug Formulation (DFM)
General Information of DFM (ID: F08264) | |||||
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Name |
Flavoxate 100 mg tablet
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Company |
Carilion Materials Management; Paddock Laboratories,
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Active Pharmaceutical Ingredient (API) | Flavoxate | API Info click to show the detail info of this API | |||
Knee osteoarthritis | ICD-11: FA01 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0MF5O | DIG Info | Ethyl acrylate | Film/membrane-forming agent ... | ||
E00DHW | DIG Info | Lactose monohydrate | Binding agent ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E0XX6I | DIG Info | Methyl methacrylate | Film/membrane-forming agent | ||
E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Silicon dioxide | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Other protein families (OPF) | ||||||
DBT Name: NFE2-related factor 2 (NRF2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Ethyl acrylate | |||||
Biological Activity | EC50 = 5110 nM (estimated based on the structural similarity with CHEMBL2107333 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.837837838 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NF2L2_HUMAN | |||||
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