Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00741)
Name
Zinc acetate
Synonyms    Click to Show/Hide the Synonyms of This API
ZINC ACETATE; Zinc diacetate; 557-34-6; Zinc(II) acetate; Acetic acid, zinc salt; Dicarbomethoxyzinc; Zinc acetate anhydrous; Acetic acid, zinc(II) salt; Zinc di(acetate); zinc;diacetate; Zn(OAc)2; UNII-H2ZEY72PME; Acetic acid, zinc salt (2:1); H2ZEY72PME; CHEBI:62984; Zinc acetate, 99%, pure; Siltex CL 4; CCRIS 3471; MFCD00012454; NSC-75801; HSDB 1043; EINECS 209-170-2; NSC 75801; AI3-04465; zinc (II) acetate; zinc acetate carrageenan; ACMC-20aj8v; Zn(II)Ac2; SCHEMBL51; ZINC ACETATE BASIC; C4H6O4Zn; Zinc Acetate 35% 40M; (CH3CO2)2Zn; DSSTox_CID_18770; DSSTox_RID_79392; DSSTox_GSID_38770; NPC-02; CHEMBL1200928; DTXSID8038770; Zinc Acetate, Trace metals grade; Tox21_302016; AKOS015837576; DB14487; NCGC00255475-01; 82279-57-0; CAS-557-34-6; CS-0013863; FT-0689089; Q204639
Clinical Status
Approved
Disease Indication Hyperphosphatemia ICD-11: 5C64 [1]
PubChem CID
11192
Formula
C4H6O4Zn
Canonical SMILES
CC(=O)[O-].CC(=O)[O-].[Zn+2]
InChI
1S/2C2H4O2.Zn/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
InChIKey
DJWUNCQRNNEAKC-UHFFFAOYSA-L
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11192"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 183.5 Topological Polar Surface Area 80.3
XlogP N.A. Complexity 25.5
Heavy Atom Count 9 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Zinc acetate 50 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Indigotindisulfonate sodium; Magnesium stearate; Propylparaben; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin, unspecified; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company Teva Select Brands
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
          Zinc acetate 25 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Indigotindisulfonate sodium; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin, unspecified; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company Teva Select Brands
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
References
1 FDA label for approved zinc acetate from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
6 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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