Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0B7AO)
DIG Name	D&C red no. 28
Synonyms	Click to Show/Hide the Synonyms of This DIG Phloxine B; D&C Red No. 28; CHEBI:87192; disodium;2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate; 4618-23-9; CI Acid Red 92; C20H2Br4Cl4Na2O5; SCHEMBL23324; CHEMBL61441; ANW-42322; AKOS015903379; AKOS030228323; DB13911; MCULE-3679050755; O841; C.I.45410; F0142; Q27159438; Disodium 2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein; Acid Red 92;3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid disodium salt; disodium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
DIG Function	Colorant
PubChem CID	6097185
Formula	C20H2Br4Cl4Na2O5
Canonical SMILES	C1=C2C(=C3C=C(C(=O)C(=C3OC2=C(C(=C1Br)[O-])Br)Br)Br)C4=C(C(=C(C(=C4Cl)Cl)Cl)Cl)C(=O)[O-].[Na+].[Na+]
InChI	1S/C20H4Br4Cl4O5.2Na/c21-5-1-3-7(8-9(20(31)32)13(26)15(28)14(27)12(8)25)4-2-6(22)17(30)11(24)19(4)33-18(3)10(23)16(5)29;;/h1-2,29H,(H,31,32);;/q;2*+1/p-2
InChIKey	GVKCHTBDSMQENH-UHFFFAOYSA-L
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6097185"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	829.6	Topological Polar Surface Area	89.5
	XlogP	N.A.	Complexity	936
	Heavy Atom Count	35	Rotatable Bond Count	1
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	5

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Minocycline	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[1]
Acyclovir	API Info	Herpes zoster [ICD-11: 1E91]		[2]
Didanosine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[3]
Oseltamivir	API Info	Influenza virus infection [ICD-11: 1E30]		[4]
Stavudine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[5]
Vancomycin	API Info	Methicillin-resistant staphylococcus infection [ICD-11: 1D01]		[6]
Cefaclor	API Info	Clostridium difficile infection [ICD-11: 1A04]		[7]
Itraconazole	API Info	Blastomycosis [ICD-11: 1F22]		[8]
Ampicillin	API Info	Endocarditis [ICD-11: 1B12]		[9]
Paromomycin	API Info	Amebiasis [ICD-11: 1A36]		[10]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Temozolomide	API Info	Brain cancer [ICD-11: 2A00]		[11]
Hydroxyurea	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[12]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[13]
Phentermine	API Info	Obesity [ICD-11: 5B81]		[14]
Calcium acetate	API Info	Hyperphosphatemia [ICD-11: 5C64]		[15]
Bromocriptine	API Info	Diabetes mellitus [ICD-11: 5A10]		[16]
Zinc acetate	API Info	Hyperphosphatemia [ICD-11: 5C64]		[17]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[18]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[19]
Hydroxyzine	API Info	Anxiety disorder [ICD-11: 6B00]		[20]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[21]
Dexmethylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[22]
Ziprasidone	API Info	Schizophrenia [ICD-11: 6A20]		[23]
Atomoxetine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[24]
Lithium carbonate	API Info	Bipolar disorder [ICD-11: 6A60]		[25]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[26]
Fluvoxamine	API Info	Obsessive-compulsive disorder [ICD-11: 6B20]		[27]
Loxapine	API Info	Schizophrenia [ICD-11: 6A20]		[28]
Lisdexamfetamine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[29]
Clomipramine	API Info	Obsessive-compulsive disorder [ICD-11: 6B20]		[30]
Tiotixene	API Info	Schizophrenia [ICD-11: 6A20]		[31]
Trimipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[32]
Oxazepam	API Info	Anxiety disorder [ICD-11: 6B00]		[33]
Naltrexone	API Info	Alcohol dependence [ICD-11: 6C40]		[34]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Temazepam	API Info	Insomnia [ICD-11: 7A00]		[35]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[36]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[37]
Propranolol	API Info	Migraine [ICD-11: 8A80]		[38]
Carbamazepine	API Info	Epilepsy [ICD-11: 8A60]		[39]
Phenytoin	API Info	Epilepsy [ICD-11: 8A60]		[40]
Zonisamide	API Info	Epilepsy [ICD-11: 8A60]		[41]
Rivastigmine	API Info	Alzheimer disease [ICD-11: 8A20]		[42]
Ketoprofen	API Info	Anaesthesia [ICD-11: 8E22]		[43]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Acetazolamide	API Info	Glaucoma [ICD-11: 9C61]		[44]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[45]
Amoxicillin	API Info	Acute otitis media [ICD-11: AB00]		[46]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Diltiazem	API Info	Essential hypertension [ICD-11: BA00]		[47]
Ramipril	API Info	Essential hypertension [ICD-11: BA00]		[48]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[49]
Propafenone	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[50]
Nitroglycerin	API Info	Acute coronary syndrome [ICD-11: BA4Z]		[51]
Acebutolol	API Info	Essential hypertension [ICD-11: BA00]		[52]
Disopyramide	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[53]
Mexiletine	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[54]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Benzonatate	API Info	Asthma [ICD-11: CA23]		[55]
Fexofenadine	API Info	Allergic rhinitis [ICD-11: CA08]		[56]
Cefdinir	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[57]
Cefadroxil	API Info	Acute tonsillitis [ICD-11: CA03]		[58]
Budesonide	API Info	Allergic rhinitis [ICD-11: CA08]		[59]
Theophylline	API Info	Chronic obstructive pulmonary disease [ICD-11: CA22]		[60]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Doxycycline	API Info	Periodontal disease [ICD-11: DA0C]		[61]
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[62]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[63]
Esomeprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[64]
Dicyclomine	API Info	Irritable bowel syndrome [ICD-11: DD91]		[65]
Mycophenolate mofetil	API Info	Crohn disease [ICD-11: DD70]		[66]
Tacrolimus	API Info	Ulcerative colitis [ICD-11: DD71]		[67]
Ursodeoxycholic acid	API Info	Hepatic fibrosis/cirrhosis [ICD-11: DB93]		[68]
Nizatidine	API Info	Peptic ulcer [ICD-11: DA61]		[69]
Trimethobenzamide	API Info	Functional nausea/vomiting [ICD-11: DD90]		[70]
Balsalazide	API Info	Ulcerative colitis [ICD-11: DD71]		[71]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Hydrochlorothiazide	API Info	Luid retention [ICD-11: EF02]		[72]
Clindamycin	API Info	Acne vulgaris [ICD-11: ED80]		[73]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[74]
Celecoxib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[75]
Etodolac	API Info	Rheumatoid arthritis [ICD-11: FA20]		[76]
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[77]
Piroxicam	API Info	Rheumatoid arthritis [ICD-11: FA20]		[78]
Rifampicin	API Info	Osteoporosis [ICD-11: FB83]		[79]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Terazosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[80]
Tamsulosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[81]
Prazosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[82]
Danazol	API Info	Endometriosis [ICD-11: GA10]		[83]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[84]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
G-protein coupled receptor (GPCR)
DBT Name: Adenosine receptor A3 (AA3R)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.48 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	AA3R_HUMAN
DBT Name: Muscarinic receptor M1 (ACM1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 > 1 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ACM1_HUMAN
DBT Name: Muscarinic receptor M2 (ACM2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.68 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ACM2_HUMAN
DBT Name: Opioid receptor mu (OPRM1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.8 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	OPRM_HUMAN
DBT Name: Serotonin receptor 1A (5HT1A)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 2.4 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	5HT1A_HUMAN
DBT Name: Alpha-1A adrenoceptor (ADA1A)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 > 3 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ADA1A_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.48 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ADA1A_HUMAN
DBT Name: Alpha-2A adrenoceptor (ADA2A)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 14 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ADA2A_HUMAN
DBT Name: Dopamine D1 receptor (DRD1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 2.1 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	DRD1_HUMAN
DBT Name: Dopamine D3 receptor (DRD3)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 1.5 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	DRD3_HUMAN
DBT Name: Histamine H3 receptor (HRH3)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 21 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	HRH3_HUMAN
DBT Name: Thromboxane A2 receptor (TBXA2R)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 > 1 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	TA2R_HUMAN
Oxidoreductase (ORase)
DBT Name: Prostaglandin G/H synthase 1 (COX-1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 2.6 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	PGH1_HUMAN
DBT Name: Prostaglandin G/H synthase 2 (COX-2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 3 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	PGH2_HUMAN
Transferase (TFase)
DBT Name: Arginine methyltransferase 1 (PRMT1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 0.7 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ANM1_HUMAN
DBT Name: VEGF-2 receptor (KDR)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 12 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	VGFR2_HUMAN
Hydrolase (HDase)
DBT Name: Acetylcholinesterase (ACHE)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 2 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ACES_HUMAN
DBT Name: Phosphodiesterase 3A (PDE3A)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.1 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	PDE3A_HUMAN
DBT Name: Phosphodiesterase 4D (PDE4D)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 0.9 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	PDE4D_HUMAN
DBT Name: Coagulation factor IIa (F2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 25 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	THRB_HUMAN
Primary active transporter (PAT)
DBT Name: Bile salt export pump (BSEP)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 < 10000 nM (estimated based on the structural similarity with CHEMBL2359093 )		[86]
Structural Similarity	Tanimoto coefficient = 0.857954545
Tested Species	Homo sapiens (Human)
UniProt ID	ABCBB_HUMAN
Potential-driven transporter (PDT)
DBT Name: Organic anion transporter 1 (OAT1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 0.064 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	S22A6_HUMAN
DBT Name: Acetylcholine VAChT transporter (SLC18A3)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 9700 nM (estimated based on the structural similarity with CHEMBL2359093 )		[87]
Structural Similarity	Tanimoto coefficient = 0.857954545
Tested Species	Rattus norvegicus (Rat)
UniProt ID	VACHT_RAT
DBT Name: Solute carrier SLCO2B1 (OATPB)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 77 % (tested by experiment)		[88]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 1 uM (tested by experiment)		[88]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 0.6 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Transmembrane channel/porin (TC/P)
DBT Name: Potassium channel Kv11.1 (KCNH2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 17 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	KCNH2_HUMAN
Nuclear receptor (NR)
DBT Name: Androgen receptor (AR)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 28 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ANDR_HUMAN
DBT Name: Estrogen receptor alpha (ESR1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 18 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	ESR1_HUMAN
DBT Name: Progesterone receptor (PGR)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 30 uM (tested by experiment)		[85]
Tested Species	Homo sapiens (Human)
UniProt ID	PRGR_HUMAN

References
1	FDA label for approved minocycline from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved acyclovir from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved didanosine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved oseltamivir from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved stavudine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved vancomycin from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved cefaclor from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved itraconazole from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved ampicillin from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved paromomycin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved temozolomide from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved hydroxyurea from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved calcium acetate from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved bromocriptine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved zinc acetate from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved hydroxyzine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved dexmethylphenidate from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved ziprasidone from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved atomoxetine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved lithium carbonate from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved fluvoxamine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved loxapine from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved lisdexamfetamine from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved clomipramine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved tiotixene from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved trimipramine from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved oxazepam from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved naltrexone from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved temazepam from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved propranolol from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved carbamazepine from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved phenytoin from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved zonisamide from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved rivastigmine from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved ketoprofen from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved acetazolamide from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved diltiazem from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved ramipril from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved flecainide from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved nitroglycerin from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved acebutolol from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved mexiletine from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved benzonatate from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved cefdinir from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved cefadroxil from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved budesonide from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved theophylline from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved doxycycline from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved dicyclomine from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved mycophenolate mofetil from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved tacrolimus from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved ursodeoxycholic acid from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved nizatidine from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved trimethobenzamide from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved balsalazide from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved hydrochlorothiazide from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved clindamycin from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
75	FDA label for approved celecoxib from the official website of the U.S. Food and Drug Administration.
76	FDA label for approved etodolac from the official website of the U.S. Food and Drug Administration.
77	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
78	FDA label for approved piroxicam from the official website of the U.S. Food and Drug Administration.
79	FDA label for approved rifampicin from the official website of the U.S. Food and Drug Administration.
80	FDA label for approved terazosin from the official website of the U.S. Food and Drug Administration.
81	FDA label for approved tamsulosin from the official website of the U.S. Food and Drug Administration.
82	FDA label for approved prazosin from the official website of the U.S. Food and Drug Administration.
83	FDA label for approved danazol from the official website of the U.S. Food and Drug Administration.
84	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
85	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
86	Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug Metab Dispos. 2012 Dec; 40(12):2332-41.
87	Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg Med Chem. 2010 Sep 15; 18(18):6922-33.
88	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.