General Information of DFM (ID: F00496)
Name	Acitretin 22.5 mg capsule
Company	Actavis Pharma; Impax Generics
Active Pharmaceutical Ingredient (API)	Acitretin		API Info click to show the detail info of this API
	Psoriasis vulgaris		ICD-11: EA90	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0NN4I	DIG Info	Dextrin	Binding agent ...
	E09YYN	DIG Info	Eisenoxyd	Colorant
	E02FBG	DIG Info	Ferrosoferric oxide	Colorant
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E07WLC	DIG Info	Sodium ascorbate	Antioxidant

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Cell line (CELL)
DBT Name: Colon cancer Caco-2 cells (Caco-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Dextrin
Biological Activity	Inhibition ratio > 55 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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