Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0NN4I)
DIG Name	Dextrin
Synonyms	Click to Show/Hide the Synonyms of This DIG Dextrin; 9004-53-9; Dextrins; Fortodex; Dextrid; Corn dextrin; Dextrina Bianca; British gum; Crystal gum; Dextrin 3; Caloreen; Dextrine; Nutriose; Starch gum; Eclipse G; Farinex MJ; Fibersol 2; Electrocol 70; Aquaflake 31; Amycol 1; Arabix 6; Arabix 7; Cream Dextrin 15; Dextrin 10; Dextrin 12; Dextrin 20; Farinex CO 2; Avedex 35; Crystal Tex 627; Dextrin 101; Fungal amylase starch; Avedex W 15; Avedex W 90; Dextrin 1104; Dextrin 1719; Avedex 58MD14C; Amaizo 1752S; Avedex 58MD14; Caswell No. 279I; Emdex 30An45; Amaizo 1706; Deprexil; C 23 (polysaccaride); Canary S 8032; Fibersol-2; Dextrin (corn); Indigestible dextrin; CCRIS 6614; D 3100 (gum); EDW 90; CPC 8071; EINECS 232-675-4; D 400E; Dextrin [BAN:JAN:NF]; EPA Pesticide Chemical Code 084503; DF 2600; AI3-01627; CORN DEXTRIN Powder; SCHEMBL1091972; Maltodextrin, dextrose equivalent 16-20; (3R,4S,5S,6R)-2-[(2R,3S,4R,5R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; Dextrin, having more than 85% of its molecules with molecular masses between 1640 and 45,000 with a claimed-average molecular mass of approximately 20,000; K648; D4657; A843422; Q177570; D-glucopyranosyl-(1->4)-D-glucopyranosyl-(1->4)-a-D-glucopyranose; (2R,3S,4S,5R)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-4,5,6-tris(oxidanyl)oxan-3-yl]oxy-4,5-bis(oxidanyl)oxan-3-yl]oxy-oxane-3,4,5-triol; (3R,4S,5S,6R)-2-[[(2R,3S,4R,5R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)-3-oxanyl]oxy]-3-oxanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (3R,4S,5S,6R)-2-{[(2R,3S,4R,5R)-4,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoicacidethylester
DIG Function	Binding agent; Diluent; Microencapsulating agent; Stiffening agent; Suspending agent; Viscosity-controlling agent
PubChem CID	62698
Formula	C18H32O16
Canonical SMILES	C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O[C@@H]2[C@H](OC([C@@H]([C@H]2O)O)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O)CO)CO)O)O)O)O
InChI	1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17?,18?/m1/s1
InChIKey	FYGDTMLNYKFZSV-MRCIVHHJSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=62698"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	504.4	Topological Polar Surface Area	269
	XlogP	-6.9	Complexity	641
	Heavy Atom Count	34	Rotatable Bond Count	7
	Hydrogen Bond Donor Count	11	Hydrogen Bond Acceptor Count	16

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Ethambutol	API Info	Pulmonary tuberculosis [ICD-11: 1B10]		[1]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[2]
Hydroxychloroquine	API Info	Malaria [ICD-11: 1F40]		[3]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[4]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Levothroid	API Info	Hypothyroidism [ICD-11: 5A00]		[5]
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[6]
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[7]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Risperidone	API Info	Schizophrenia [ICD-11: 6A20]		[8]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[9]
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[10]
Mirtazapine	API Info	Major depressive disorder [ICD-11: 6A70]		[11]
Trazodone	API Info	Major depressive disorder [ICD-11: 6A70]		[12]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Dextroamphetamine	API Info	Narcolepsy [ICD-11: 7A20]		[13]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[14]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[15]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[16]
Ketoprofen	API Info	Anaesthesia [ICD-11: 8E22]		[17]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[18]
Acetylcysteine	API Info	Pterygium [ICD-11: 9A61]		[19]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[20]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Diltiazem	API Info	Essential hypertension [ICD-11: BA00]		[21]
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[22]
Metoprolol	API Info	Essential hypertension [ICD-11: BA00]		[23]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[24]
Clonidine	API Info	Essential hypertension [ICD-11: BA00]		[25]
Caffeine	API Info	Orthostatic hypotension [ICD-11: BA21]		[26]
Propafenone	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[27]
Spironolactone	API Info	Congestive heart failure [ICD-11: BD10]		[28]
Indapamide	API Info	Essential hypertension [ICD-11: BA00]		[29]
Ivabradine	API Info	Angina pectoris [ICD-11: BA40]		[30]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[31]
Guaifenesin	API Info	Asthma [ICD-11: CA23]		[32]
Clarithromycin	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[33]
Loratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[34]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Bisacodyl	API Info	Irritable bowel syndrome [ICD-11: DD91]		[35]
Meclizine	API Info	Functional nausea/vomiting [ICD-11: DD90]		[36]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[37]
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[38]
Ranitidine	API Info	Gastric ulcer [ICD-11: DA60]		[39]
Bismuth subsalicylate	API Info	Irritable bowel syndrome [ICD-11: DD91]		[40]
Dimenhydrinate	API Info	Functional nausea/vomiting [ICD-11: DD90]		[41]
Mycophenolic acid	API Info	Crohn disease [ICD-11: DD70]		[42]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Acitretin	API Info	Psoriasis vulgaris [ICD-11: EA90]		[43]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Etodolac	API Info	Rheumatoid arthritis [ICD-11: FA20]		[44]
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[45]
Dexamethasone	API Info	Rheumatoid arthritis [ICD-11: FA20]		[46]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[47]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Cell line (CELL)
DBT Name: Colon cancer Caco-2 cells (Caco-2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 55 % (tested by experiment)		[48]
Tested Species	Homo sapiens (Human)

References
1	FDA label for approved ethambutol from the official website of the U.S. Food and Drug Administration.
2	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
3	FDA label for approved hydroxychloroquine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved levothroid from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved trazodone from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved dextroamphetamine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved ketoprofen from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved acetylcysteine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved diltiazem from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved metoprolol from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved clonidine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved flecainide from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved spironolactone from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved indapamide from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved ivabradine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved guaifenesin from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved loratadine from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved meclizine from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved ranitidine from the official website of the U.S. Food and Drug Administration.
40	Bismuth Subsalicylate.
41	FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved mycophenolic acid from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved acitretin from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved etodolac from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved dexamethasone from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
48	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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