Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00012)
Name
Acitretin
Synonyms    Click to Show/Hide the Synonyms of This API
Acitretin; 55079-83-9; Etretin; Soriatane; Neotigason; all-trans-Acitretin; Acitretine; Retinoid etretin; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; Acitretina; Acitretinum; Ro 10-1670; Ro 10-1670/000; UNII-LCH760E9T7; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; CHEBI:50173; 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (all-E)-; Ro-101670000; LCH760E9T7; 54757-46-9; NCGC00163127-02; Acitretine [French]; Acitretinum [Latin]; Acitretina [Spanish]; 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-, (all-E)-; Soriatane CK; Soriatane (TN); CCRIS 5534; Ro-10-1670; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; HSDB 7187; EINECS 259-474-4; CHEBI:50172; Acitretin/; all-trans-Etretin; Acitretin [USAN:USP:INN:BAN]; Acitretin,(S); Acitretin (USP/INN); Spectrum5_002065; DSSTox_CID_2553; Ro-10-1670/000; SCHEMBL3759; CHEMBL1131; DSSTox_RID_76624; DSSTox_GSID_22553; MLS001076667; BIDD:GT0617; GTPL7598; DTXSID6022553; BCPP000437; HMS2234L17; HMS3259J12; HMS3714E17; 2-Ethynyl-5-Methylpyridine1-oxide; Acitretin, >=98.0% (HPLC); HY-B0107; ZINC3798734; Tox21_112012; ABP000589; BDBM50088429; MFCD00866632; STL565770; AKOS015889991; AB07538; AC-4702; BCP9000229; CCG-220668; CS-1855; DB00459; KS-5246; NC00723; 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-; NCGC00163127-01; NCGC00163127-03; (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; AS-12644; SMR000499573; AB0007949; CAS-55079-83-9; SW199134-2; D02754; AB00698376-08; AB00698376_09; Acitretin 100 microg/mL in Acetonitrile:Acetone; 079A839; A830475; Q341500; SR-01000763200; SR-01000763200-3; BRD-K90699611-001-01-4; Acitretin, British Pharmacopoeia (BP) Reference Standard; Acitretin, European Pharmacopoeia (EP) Reference Standard; Acitretin, United States Pharmacopeia (USP) Reference Standard; Acitretin, Pharmaceutical Secondary Standard; Certified Reference Material; 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, (2E,4E,6E,8E)-
Clinical Status
Approved
Disease Indication Psoriasis vulgaris ICD-11: EA90 [1]
PubChem CID
5284513
Formula
C21H26O3
Canonical SMILES
CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC
InChI
1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
InChIKey
IHUNBGSDBOWDMA-AQFIFDHZSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5284513"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 326.4 Topological Polar Surface Area 46.5
XlogP 6.1 Complexity 539
Heavy Atom Count 24 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Acitretin 25 mg capsule Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Indigotindisulfonate sodium; Sodium ascorbate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Poloxamer 188; Crospovidone (15 mpa.s at 5%); Gelatin, unspecified; Microcrystalline cellulose; Povidone k90; Shellac
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Impax Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide yellow; Titanium dioxide; Povidone; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Sigmapharm Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide yellow; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Povidones
                   Dosage Form Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Edetate disodium; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Titanium dioxide; Poloxamer 407; Gelatin, unspecified; Microcrystalline cellulose; Povidone, unspecified; Shellac
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Stiefel Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin, unspecified; Microcrystalline cellulose
                   Dosage Form Oral Capsule
                   Company GlaxoSmithKline; Prasco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
          Acitretin 17.5 mg capsule Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Indigotindisulfonate sodium; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Poloxamer 188; Crospovidone (15 mpa.s at 5%); Gelatin, unspecified; Microcrystalline cellulose; Povidone k90; Shellac
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Crospovidone; Poloxamer 188; Aluminum oxide; Cellulose, microcrystalline; Gelatin; Povidone k90; Shellac
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [5]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Impax Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Sigmapharm Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Povidones
                   Dosage Form Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Stiefel Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin, unspecified; Microcrystalline cellulose
                   Dosage Form Oral Capsule
                   Company GlaxoSmithKline
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
          Acitretin 10 mg capsule Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Indigotindisulfonate sodium; Sodium ascorbate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Poloxamer 188; Crospovidone (15 mpa.s at 5%); Gelatin, unspecified; Microcrystalline cellulose; Povidone k90; Shellac
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Impax Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide yellow; Titanium dioxide; Povidone; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Sigmapharm Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Maltodextrin; Sodium ascorbate; Ferric oxide yellow; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Povidones
                   Dosage Form Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ammonia; Edetate disodium; Ferric oxide red; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Poloxamer 407; Gelatin, unspecified; Microcrystalline cellulose; Shellac
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Poloxamer 407 DIG Info Albendazole monooxygenase (EC50 = 32.8 uM) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Stiefel Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin, unspecified; Microcrystalline cellulose
                   Dosage Form Oral Capsule
                   Company GlaxoSmithKline; Prasco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
          Acitretin 22.5 mg capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Cellulose, microcrystalline; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Impax Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Sodium ascorbate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Stiefel Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [7]
References
1 FDA label for approved acitretin from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
6 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
7 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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