General Information of DFM (ID: F04760)
Name	Clopidogrel 300 mg tablet
Company	Wockhardt
Active Pharmaceutical Ingredient (API)	Clopidogrel		API Info click to show the detail info of this API
	Deep vein thrombosis		ICD-11: BD71	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E09YYN	DIG Info	Eisenoxyd	Colorant
	E0EI2M	DIG Info	Glyceryl dibehenate	Binding agent ...
	E00DHW	DIG Info	Lactose monohydrate	Binding agent ...
	E0Q6DQ	DIG Info	Mannitol	Diluent ...
	E09BYS	DIG Info	Polyethylene glycol 6000	Coating agent ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...
	E0T2AJ	DIG Info	Triacetin	Humectant ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyethylene glycol 6000
Biological Activity	Inhibition ratio < 70 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Transmembrane channel/porin (TC/P)
DBT Name: Glycine receptor alpha-1 (GLRA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Mannitol
Biological Activity	EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 )					[2]
Structural Similarity	Tanimoto coefficient = 0.804878049
Tested Species	Homo sapiens (Human)
UniProt ID	GLRA1_HUMAN

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

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