General Information of DFM (ID: F05855)
Name	Didanosine 200 mg tablet
Company	Aurobindo Pharma
Active Pharmaceutical Ingredient (API)	Didanosine		API Info click to show the detail info of this API
	Human immunodeficiency virus infection		ICD-11: 1C60	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0BI3X	DIG Info	Aspartame	Flavoring agent
	E0JA5E	DIG Info	Calcium carbonate	Binding agent ...
	E0PE9M	DIG Info	Crospovidone	Disintegrant
	E04KSN	DIG Info	Hexahydric alcohol	Diluent ...
	E0MG7O	DIG Info	Magnesium hydroxide	Adsorbent ...
	E01UTP	DIG Info	Magnesium stearate	lubricant

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Crospovidone
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Hydrolase (HDase)
DBT Name: Matrix metalloproteinase-1 (MMP1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Aspartame
Biological Activity	IC50 = 20000 nM (estimated based on the structural similarity with CHEMBL62186 )					[2]
Structural Similarity	Tanimoto coefficient = 0.916666667
Tested Species	Homo sapiens (Human)
UniProt ID	MMP1_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IX (CA9)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Calcium carbonate
Biological Activity	Ki = 8600 nM (estimated based on the structural similarity with CHEMBL1161632 )					[3]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	CAH9_HUMAN
DBT Name: Carbonic anhydrase VII (CA7)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Calcium carbonate
Biological Activity	Ki = 160000 nM (estimated based on the structural similarity with CHEMBL1161632 )					[4]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	CAH7_HUMAN
Nuclear receptor (NR)
DBT Name: Pregnane X receptor (NR1I2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Aspartame
Biological Activity	Ki = 13 uM (tested by experiment)					[5]
Tested Species	Homo sapiens (Human)
UniProt ID	NR1I2_HUMAN

References
1	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2	Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket. Bioorg Med Chem Lett. (1997) 7:193-198.
3	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.
4	Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3139-43.
5	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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