General Information of DFM (ID: F07173)
Name	Dutasteride 0.5 mg capsule
Company	Amneal Pharmaceuticals; AvKARE
Active Pharmaceutical Ingredient (API)	Dutasteride		API Info click to show the detail info of this API
	Prostatic hyperplasia		ICD-11: GA90	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0J0LX	DIG Info	Butylated hydroxytoluene	Antioxidant
	E0M0IE	DIG Info	Ferric hydroxide oxide yellow	Colorant
	E06WYP	DIG Info	Glycerin	Antimicrobial preservative ...
	E0BS4M	DIG Info	Glyceryl caprylate/caprate	Emollient ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase I (CA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylated hydroxytoluene
Biological Activity	Ki = 245200 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH1_HUMAN
DBT Name: Carbonic anhydrase II (CA2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylated hydroxytoluene
Biological Activity	Ki = 630 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH2_HUMAN

References
1	Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15; 17(8):3207-11.

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