General Information of DFM (ID: F07389)
Name	Erythromycin 250 mg tablet
Company	A-S Medication Solutions
Active Pharmaceutical Ingredient (API)	Erythromycin		API Info click to show the detail info of this API
	Pelvic inflammatory disease		ICD-11: GA05	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0DI4R	DIG Info	Lithol rubin BCA	Colorant
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E0M5SQ	DIG Info	Sodium citrate anhydrous	Alkalizing agent ...
	E0SA9J	DIG Info	Sorbic acid	Antimicrobial preservative
	E0T3FM	DIG Info	Sorbitan monooleate	Dispersing agent ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium citrate anhydrous
Biological Activity	Ki = 99 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.

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