General Information of DFM (ID: F15208)
Name	Nicotinic acid 250 mg capsule
Company	Time Cap Labs
Active Pharmaceutical Ingredient (API)	Nicotinic acid		API Info click to show the detail info of this API
	Lung cancer		ICD-11: 2C25	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0I4EJ	DIG Info	Riboflavin	Colorant
	E0Q3PU	DIG Info	Saccharose	Binding agent ...
	E0L0MR	DIG Info	Sunset yellow FCF	Colorant
	E0QY1F	DIG Info	Talc	Anticaking agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Transferase (TFase)
DBT Name: Thiosulfate sulfurtransferase (TST)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Riboflavin
Biological Activity	IC50 = 8800 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	THTR_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Hsp60-Hsp10 complex (HSPD1-HSPE1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Riboflavin
Biological Activity	IC50 > 100000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CH60_HUMAN ; CH10_HUMAN
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sunset yellow FCF
Biological Activity	Inhibition ratio = 54.5 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sunset yellow FCF
Biological Activity	Ki = 68.4 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sunset yellow FCF
Biological Activity	Ki = 74 uM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Other protein families (OPF)
DBT Name: Riboflavin-binding protein (RTBDN)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Riboflavin
Biological Activity	Ki = 350 nM (tested by experiment)					[4]
Tested Species	Gallus gallus (Chicken)
UniProt ID	RBP_CHICK
DBT Name: Thrombopoietin receptor (MPL)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sunset yellow FCF
Biological Activity	EC50 = 3000 nM (estimated based on the structural similarity with CHEMBL122867 )					[5]
Structural Similarity	Tanimoto coefficient = 0.93081761
Tested Species	Homo sapiens (Human)
UniProt ID	TPOR_HUMAN

References
1	HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1; 29(9):1106-1112.
2	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4	Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery - A Thermodynamic and Kinetic Study. ACS Med Chem Lett. 2011 May 12; 2(5):363-367.
5	Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem. 2001 Oct 25; 44(22):3730-45.

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