Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00466)
Name
Nicotinic acid
Synonyms    Click to Show/Hide the Synonyms of This API
nicotinic acid; niacin; 59-67-6; Pyridine-3-carboxylic acid; 3-pyridinecarboxylic acid; 3-Carboxypyridine; wampocap; Niaspan; Apelagrin; Pellagrin; Akotin; Daskil; Efacin; Pelonin; Acidum nicotinicum; nicamin; nicobid; nicocap; nicolar; Enduracin; Nicodelmine; Niconacid; Nicotinipca; Pellagramin; Direktan; Nicacid; Nicangin; Peviton; vitamin B3; Bionic; Diacin; Nyclin; Vitaplex N; Davitamon PP; Nico-Span; Tega-Span; Nicocidin; Nicocrisina; Niconazid; Nicoside; Nicotamin; Nicotene; Nicovasan; Nicovasen; Nipellen; SK-Niacin; Naotin; Nicodan; Nicodon; Niconat; Nicosan 3; Nicosyl; Nicotil; 3-Carboxylpyridine; Nicotine acid; Niacor; Slo-niacin; Nicotinsaure; Nico-400; Acide nicotinique; 3-Picolinic acid; Pyridine-beta-carboxylic acid; Nicagin; anti-Pellagra vitamin; Caswell No. 598; PP Factor; Kyselina nikotinova; P.P. factor; Pellagra preventive factor; Nicotinsaure [German]; Acido nicotinico; 3-Pyridylcarboxylic acid; m-Pyridinecarboxylic acid; Kyselina nikotinova [Czech]; MFCD00006391; niacine; CCRIS 1902; Pyridine-carboxylique-3; EPA Pesticide Chemical Code 056701; Acide nicotinique [INN-French]; Acido nicotinico [INN-Spanish]; Acidum nicotinicum [INN-Latin]; HSDB 3134; Pyridine-carboxylique-3 [French]; AI3-18994; Pyridinecarboxylic acid, 3-; Niacin [USP]; SR 4390; BRN 0109591; UNII-2679MF687A; CHEMBL573; beta-pyridinecarboxylic acid; MLS000069603; Pyridine-.beta.-carboxylic acid; CHEBI:15940; Niacin (USP); 2679MF687A; NSC-169454; P.P. factor-pellagra preventive factor; CAS-59-67-6; NCGC00016268-02; SMR000059024; DSSTox_CID_932; Nicotinic acid, 99.5%; [5, 6-3H]-niacin; DSSTox_RID_75875; DSSTox_GSID_20932; Niacin [USAN]; Niacin (nicotinic acid); SR-01000722017; EINECS 200-441-0; NIASPAN TITRATION STARTER PACK; NSC 169454; pellagra; Nikotinsaeure; Ncotnc acd; Nicotinic acid, specified according to the requirements of Ph. Eur; preventative factor; antipellagra vitamin; Niaspan (TN); 3PyrCOOH; [3H]nicotinic acid; Niacor (TN); Nicotinic Acid,(S); PubChem2594; [3H]-Nicotinic acid; Nicotinic acid [INN]; Spectrum_001063; 3-Pyridinecarboxylicacid; Nicotinic acid, Ph Eur; 5-pyridinecarboxylic acid; Opera_ID_1346; Prestwick0_000881; Prestwick1_000881; Prestwick2_000881; Prestwick3_000881; Pyridine-3-carbonic acid; Spectrum2_000006; Spectrum3_000515; Spectrum4_000965; Spectrum5_001287; 3-Pyridyl carboxylic acid; Nicotinic acid-d3(major); ACMC-1AS6M; WLN: T6NJ CVQ; 3-pyridine carboxylic acid; bmse000104; Nicotinic acid, >=98%; EC 200-441-0; SCHEMBL1433; Oprea1_514398; BSPBio_000662; BSPBio_002069; KBioGR_001309; KBioSS_001543; 5-22-02-00057 (Beilstein Handbook Reference); BIDD:GT0644; DivK1c_000695; Nicotinic acid (JP17/INN); SPECTRUM1500430; .beta.-Pyridinecarboxylic acid; SPBio_000011; SPBio_002881; BPBio1_000730; GTPL1588; GTPL1594; ZINC1795; DTXSID1020932; BDBM23515; HMS502C17; KBio1_000695; KBio2_001543; KBio2_004111; KBio2_006679; KBio3_001569; ABT-919; NINDS_000695; HMS1570B04; HMS1920P17; HMS2091H22; HMS2097B04; HMS2236A05; HMS3259K21; HMS3371E07; HMS3655K08; HMS3714B04; Pharmakon1600-01500430; Nicotinic acid, analytical standard; BCP16301; HY-B0143; STR00112; Tox21_110337; Tox21_201420; Tox21_302904; ANW-75276; BBL037343; CCG-38340; Nicotinic acid, for synthesis, 99%; NSC169454; NSC757241; SBB004279; STK301803; Nicotinic acid (Vitamin B3) solution; AKOS000118980; Nicotinic acid, >=99.5% (HPLC); Tox21_110337_1; AM81316; CS-1946; DB00627; EBD2198325; MCULE-3788394698; NC00524; Nicotinic Acid 1.0 mg/ml in Methanol; NSC-757241; PS-4255; SDCCGMLS-0066610.P001; IDI1_000695; NCGC00016268-01; NCGC00016268-03; NCGC00016268-04; NCGC00016268-05; NCGC00016268-08; NCGC00016268-09; NCGC00094734-01; NCGC00094734-02; NCGC00256537-01; NCGC00258971-01; AC-22484; AK-46486; BP-21419; NCI60_001041; Nicotinic acid, NIST(R) SRM(R) 148; Nicotinic acid, plant cell culture tested; ST097540; SY011111; SBI-0051456.P003; DB-007765; Nicotinic Acid [Matrix for MALDI-TOF/MS]; AB00052050; FT-0600004; FT-0672715; FT-0672716; FT-0672717; FT-0672718; FT-0773496; Nicotinic acid 10 microg/mL in Acetonitrile; Nicotinic acid, purum, >=99.0% (HPLC); SW197229-3; C00253; D00049; M-5918; Nicotinic acid, SAJ special grade, >=99.5%; 11054-EP2269610A2; 11054-EP2269990A1; 11054-EP2270002A1; 11054-EP2270014A1; 11054-EP2272825A2; 11054-EP2272834A1; 11054-EP2272848A1; 11054-EP2274983A1; 11054-EP2275401A1; 11054-EP2277848A1; 11054-EP2280001A1; 11054-EP2289510A1; 11054-EP2292228A1; 11054-EP2292610A1; 11054-EP2295406A1; 11054-EP2295409A1; 11054-EP2295424A1; 11054-EP2298742A1; 11054-EP2298772A1; 11054-EP2298776A1; 11054-EP2298779A1; 11054-EP2301923A1; 11054-EP2301929A1; 11054-EP2301935A1; 11054-EP2301937A1; 11054-EP2305651A1; 11054-EP2305674A1; 11054-EP2308838A1; 11054-EP2308839A1; 11054-EP2308848A1; 11054-EP2308854A1; 11054-EP2308858A1; 11054-EP2308874A1; 11054-EP2311808A1; 11054-EP2311816A1; 11054-EP2311817A1; 11054-EP2311829A1; 11054-EP2311830A1; 11054-EP2314588A1; 11054-EP2316457A1; 11054-EP2316458A1; 11054-EP2316825A1; 11054-EP2316826A1; 11054-EP2316827A1; 11054-EP2316828A1; AB00052050-13; AB00052050_14; AB00052050_15; Nicotinic acid, meets USP testing specifications; AC-907/25014105; L001199; Nicotinic acid, Vetec(TM) reagent grade, >=98%; Q134658; J-523605; SR-01000722017-2; SR-01000722017-3; SR-01000722017-4; Z56755709; 3DDB011E-F3A6-45B6-A2D2-77B2A6E8936E; F2191-0082; Niacin, United States Pharmacopeia (USP) Reference Standard; Nicotinic acid, certified reference material, TraceCERT(R); Nicotinic acid, European Pharmacopoeia (EP) Reference Standard; Nicotinic acid, matrix substance for MALDI-MS, >=99.5% (HPLC); Nicotinic acid, for inorganic trace analysis, >=99.999% (metals basis); 101113-41-1
Clinical Status
Approved
Disease Indication Lung cancer ICD-11: 2C25 [1]
PubChem CID
938
Formula
C6H5NO2
Canonical SMILES
C1=CC(=CN=C1)C(=O)O
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChIKey
PVNIIMVLHYAWGP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=938"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 123.11 Topological Polar Surface Area 50.2
XlogP 0.4 Complexity 114
Heavy Atom Count 9 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Nicotinic acid 1000 mg tablet Click to Show/Hide the Full List of Formulation(s):        12 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Lecithin, soybean; Polyethylene glycol 1000; Silicon dioxide; Hydroxypropyl cellulose (type e); Polyvinyl alcohol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
Polyethylene glycol 1000 DIG Info Cytochrome P450 2E1 (IC50 = 75.3 uM) [3]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Polyethylene glycol 400; Hydroxyethyl cellulose (4000 cps at 1%); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Marlex Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Polyethylene glycol 400; Hydroxyethyl cellulose (4000 mpa.s at 1%); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Amneal Pharmaceuticals; AvPAK; Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Dispensing Solution; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AbbVie
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum oxide; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Hypromellose 2910 (10000 mpa.s); Povidone k90
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyvinyl alcohol; Silicon dioxide; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Avera McKennan Hospital; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nicotinic acid 500 mg tablet Click to Show/Hide the Full List of Formulation(s):        16 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Lecithin, soybean; Polyethylene glycol 1000; Silicon dioxide; Hydroxypropyl cellulose (type e); Polyvinyl alcohol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
Polyethylene glycol 1000 DIG Info Cytochrome P450 2E1 (IC50 = 75.3 uM) [3]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Polyethylene glycol 400; Hydroxyethyl cellulose (4000 cps at 1%); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Marlex Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Polyethylene glycol 400; Hydroxyethyl cellulose (4000 mpa.s at 1%); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Amneal Pharmaceuticals; AvPAK; Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Dispensing Solution; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum oxide; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AbbVie
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Hypromellose 2910 (10000 mpa.s); Povidone k90
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyvinyl alcohol; Silicon dioxide; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Avera McKennan Hospital; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Croscarmellose sodium; Hydrogenated soybean oil; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Avondale Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
          Nicotinic acid 750 mg tablet Click to Show/Hide the Full List of Formulation(s):        11 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AbbVie
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum oxide; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Hydroxyethyl cellulose (4000 cps at 1%); Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Marlex Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Hydroxyethyl cellulose (4000 mpa.s at 1%); Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c yellow no. 6; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Hypromellose 2910 (10000 mpa.s); Povidone k90
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyvinyl alcohol; Silicon dioxide; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nicotinic acid 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Riboflavin; Fd&c yellow no. 6; Sucrose; Talc; Fd&c green no. 3; Gelatin; Starch, corn; Turmeric
                   Dosage Form Extended Release Oral Capsule
                   Company Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Riboflavin DIG Info Riboflavin-binding protein (Ki = 350 nM) [8]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [7]
          Nicotinic acid 500 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Sucrose; Talc; Titanium dioxide; Gelatin; Shellac
                   Dosage Form Extended Release Oral Capsule
                   Company Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [7]
References
1 FDA label for approved nicotinic acid from the official website of the U.S. Food and Drug Administration.
2 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
7 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
8 Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery - A Thermodynamic and Kinetic Study. ACS Med Chem Lett. 2011 May 12; 2(5):363-367.

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