Details of the Drug Formulation (DFM)
General Information of DFM (ID: F15376) | |||||
---|---|---|---|---|---|
Name |
Nimodipine 30 mg capsule
|
||||
Company |
Cardinal Health
|
||||
Active Pharmaceutical Ingredient (API) | Nimodipine | API Info click to show the detail info of this API | |||
Cerebral vasospasm | ICD-11: BA85 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E02FBG | DIG Info | Ferrosoferric oxide | Colorant | ||
E06WYP | DIG Info | Glycerin | Antimicrobial preservative ... | ||
E04KSN | DIG Info | Hexahydric alcohol | Diluent ... | ||
E0Q6DQ | DIG Info | Mannitol | Diluent ... | ||
E0M1JK | DIG Info | Propylene glycol | Antimicrobial preservative ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
---|---|---|---|---|---|---|
Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylene glycol | |||||
Biological Activity | Inhibition ratio < 20 % (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Transmembrane channel/porin (TC/P) | ||||||
DBT Name: Glycine receptor alpha-1 (GLRA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Mannitol | |||||
Biological Activity | EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.804878049 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | GLRA1_HUMAN | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.