General Information of DFM (ID: F20304)
Name	Sodium fluoride 2.2 mg tablet
Company	Fluoritab Corporation
Active Pharmaceutical Ingredient (API)	Sodium fluoride		API Info click to show the detail info of this API
	Periodontal disease		ICD-11: DA0C	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SJ4H	DIG Info	Beta-D-lactose	Diluent ...
	E01UTP	DIG Info	Magnesium stearate	lubricant
	E04NIZ	DIG Info	Saccharin sodium anhydrous	Flavoring agent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase I (CA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Saccharin sodium anhydrous
Biological Activity	Ki = 18540 nM (estimated based on the structural similarity with CHEMBL310671 )					[2]
Structural Similarity	Tanimoto coefficient = 0.970873786
Tested Species	Homo sapiens (Human)
UniProt ID	CAH1_HUMAN

References
1	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15; 17(14):5054-8.

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