Details of the Drug Formulation (DFM)

General Information of DFM (ID: F22842)
Name
Ziprasidone 60 mg capsule
Company
Bryant Ranch Prepack; Golden State Medical Supply
Active Pharmaceutical Ingredient (API) Ziprasidone API Info click to show the detail info of this API
Schizophrenia ICD-11: 6A20 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0A1CS DIG Info Ammonia Alkalizing agent
E01VDF DIG Info Butyl alcohol Flavoring agent ...
E02FBG DIG Info Ferrosoferric oxide Colorant
E0N2PK DIG Info Isopropyl alcohol Antimicrobial preservative ...
E01UTP DIG Info Magnesium stearate lubricant
E0ND5Z DIG Info Potassium hydroxide Alkalizing agent
E0M1JK DIG Info Propylene glycol Antimicrobial preservative ...
E01UTV DIG Info Silicon dioxide Anticaking agent ...
E05BSD DIG Info Titanium dioxide Coating agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Propylene glycol
                    Biological Activity Inhibition ratio < 20 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Magnesium stearate
                    Biological Activity Protein expression downregulation (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Silicon dioxide
                    Biological Activity Protein expression downregulation (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Cell line (CELL)
            DBT Name: Lymphoma P388/ADR cells (P388/ADR) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Isopropyl alcohol
                    Biological Activity IC50 = 0.22 uM (estimated based on the structural similarity with CHEMBL545 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.789473684
                    Tested Species Mus musculus (Mouse)
                    Cellosaurus ID CVCL_IZ75
References
1 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
3 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.

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