Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23135)
Name
Dipivefrin 0.1% solution
Company
Allergan Pharmaceutical
Active Pharmaceutical Ingredient (API) Dipivefrin API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0X1KL DIG Info Benzalkonium chloride Antimicrobial preservative ...
E0FY2S DIG Info Edetate disodium Complexing agent
E0H0KW DIG Info Hydrochloric acid Acidulant
E0T4TW DIG Info Sodium chloride Diluent ...
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Monoamine oxidase (MAO) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzalkonium chloride
                    Biological Activity IC50 = 8200 nM (estimated based on the structural similarity with CHEMBL8695 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.97260274
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID AOFA_RAT ; AOFB_RAT
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hydrochloric acid
                    Biological Activity Ki = 90000 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
            DBT Name: Carbonic anhydrase V (CA5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hydrochloric acid
                    Biological Activity Ki = 156 nM (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH5A_HUMAN ; CAH5B_HUMAN
      Potential-driven transporter (PDT)
            DBT Name: Solute carrier SLCO2B1 (OATPB) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzalkonium chloride
                    Biological Activity Inhibition ratio = 77.4 % (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID SO2B1_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzalkonium chloride
                    Biological Activity Ki = 62.1 uM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID SO2B1_HUMAN
References
1 Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes. J Med Chem. 1983 Jul; 26(7):1036-42.
2 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5769-73.
3 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.
4 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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