General Information of DFM (ID: F23409)
Name	Cyclosporine 25mg capsule
Company	Novartis
Active Pharmaceutical Ingredient (API)	Cyclosporin A		API Info click to show the detail info of this API
	Rheumatoid arthritis		ICD-11: FA20	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SF4Y	DIG Info	Ethanol	Antimicrobial preservative ...
	E0M0IE	DIG Info	Ferric hydroxide oxide yellow	Colorant
	E00FTX	DIG Info	Gelatin	Other agent
	E06WYP	DIG Info	Glycerin	Antimicrobial preservative ...
	E0L1TV	DIG Info	Haematite red	Colorant
	E0G5FT	DIG Info	Sorbitan tristearate	Dispersing agent ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...
	E0I4VY	DIG Info	Triolein	Complexing agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Cytochrome P450 2E1 (CYP2E1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Gelatin
Biological Activity	IC50 = 141.2 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Gelatin
Biological Activity	EC50 = 249.5 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Gelatin
Biological Activity	EC50 = 20.5 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2CJ_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Gelatin
Biological Activity	EC50 = 379.9 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN
Hydrolase (HDase)
DBT Name: Oleamide hydrolase 1 (FAAH)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Triolein
Biological Activity	IC50 = 11000 nM (estimated based on the structural similarity with CHEMBL230967 )					[2]
Structural Similarity	Tanimoto coefficient = 0.93442623
Tested Species	Rattus norvegicus (Rat)
UniProt ID	FAAH1_RAT
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Gelatin
Biological Activity	IC50 = 40.9 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN

References
1	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2	Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4; 50(20):5012-23.

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