Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F23558) | |||||
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| Name |
Tapentadol Hydrochloride eq 20mg base/ml solution
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| Company |
Collegium Pharm
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| Active Pharmaceutical Ingredient (API) | Tapentadol |
API Info
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| Neuropathic pain | ICD-11: 8E43 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E09QIG | DIG Info | Citric acid monohydrate | Acidulant ... | ||
| E0L2PN | DIG Info | Sodium hydroxide | Alkalizing agent | ||
| E04KTP | DIG Info | Sucralose | Flavoring agent | ||
| E0H2SC | DIG Info | Water | Solvent | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Lyase/isomerase/ligase (L/I/G) | ||||||
| DBT Name: Carbonic anhydrase II (CA2) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Sucralose | |||||
| Biological Activity | Ki = 300 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CAH2_HUMAN | |||||
| DBT Name: Carbonic anhydrase IX (CA9) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Sucralose | |||||
| Biological Activity | Ki = 2200 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CAH9_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661. | ||||
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