Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E09QIG)
DIG Name	Citric acid monohydrate
Synonyms	Click to Show/Hide the Synonyms of This DIG Citric acid monohydrate; 5949-29-1; Citric acid hydrate; 2-hydroxypropane-1,2,3-tricarboxylic acid hydrate; CITRIC ACID, MONOHYDRATE; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate; UNII-2968PHW8QP; MFCD00149972; 2968PHW8QP; CHEBI:31404; 2-hydroxypropane-1,2,3-tricarboxylic acid;hydrate; SBB068612; 2-Hydroxy-1,2,3-propanetricarboxylic acid monohydrate; Acidum citricum monohydricum; Citric acid monohydrate (USP); Citric acid monohydrate [USP]; Citric acid monohydrate, 99+%, ACS reagent; Citric acid monohydrate, 99.5%, for analysis; citrate hydrate; C6H8O7.H2O; citric acid water; water citric acid; Citric acid (TN); ACMC-20alep; monohydrate citric acid; citric acid mono-hydrate; SCHEMBL22721; Citric acid hydrate (JP17); CHEMBL2107737; DTXSID7074668; EBD9925; Citric acid monohydrate, Ultrapure; AKOS015918207; Citric acid monohydrate, p.a., 99.5%; AK142751; BS-17269; Citric acid monohydrate, AR, >=99.5%; M189; DB-053400; FT-0623958; Citric acid monohydrate, BioXtra, >=99.5%; C12649; Citric acid monohydrate, LR, 99.5-100.5%; Citric acid monohydrate, technical, crystalline; D01222; Citric acid monohydrate, ACS reagent, >=99.0%; Citric Acid, Monohydrate, Crystal, Reagent, ACS; 2-hydroxypropane-1,2,3-tricarboxylic acid, hydrate; Citric acid monohydrate, JIS special grade, >=99.5%; Citric acid monohydrate, SAJ first grade, >=99.5%; Q27114303; Citric acid monohydrate, Vetec(TM) reagent grade, >=98%; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1); Citric acid monohydrate, reagent grade, >=98% (GC/titration); Citric acid monohydrate, >=99.5%, suitable for amino acid analysis; Citric acid monohydrate, European Pharmacopoeia (EP) Reference Standard; Citric acid monohydrate, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.5-100.5%; Citric acid monohydrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%; Citric acid monohydrate, puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit
DIG Function	Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
PubChem CID	22230
Formula	C6H10O8
Canonical SMILES	C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O
InChI	1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
InChIKey	YASYEJJMZJALEJ-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=22230"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	210.14	Topological Polar Surface Area	133
	XlogP	N.A.	Complexity	227
	Heavy Atom Count	14	Rotatable Bond Count	5
	Hydrogen Bond Donor Count	5	Hydrogen Bond Acceptor Count	8

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[1]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Prednisolone	API Info	Multiple myeloma [ICD-11: 2A83]		[2]
Hydroxyurea	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[3]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Simvastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[4]
Phentermine	API Info	Obesity [ICD-11: 5B81]		[5]
Potassium chloride	API Info	Hypokalemia [ICD-11: 5C77]		[6]
Bromocriptine	API Info	Diabetes mellitus [ICD-11: 5A10]		[7]
Cabergoline	API Info	Hyperprolactinaemia [ICD-11: 5A60]		[8]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[9]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[10]
Ziprasidone	API Info	Schizophrenia [ICD-11: 6A20]		[11]
Mirtazapine	API Info	Major depressive disorder [ICD-11: 6A70]		[12]
Clozapine	API Info	Schizophrenia [ICD-11: 6A20]		[13]
Amphetamine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[14]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[15]
Desvenlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[16]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[17]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[18]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[19]
Carbamazepine	API Info	Epilepsy [ICD-11: 8A60]		[20]
Oxymorphone	API Info	Anaesthesia [ICD-11: 8E22]		[21]
Tapentadol	API Info	Neuropathic pain [ICD-11: 8E43]		[22]
Rasagiline	API Info	Parkinsonism [ICD-11: 8A00]		[23]
Selegiline	API Info	Parkinsonism [ICD-11: 8A00]		[24]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[25]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[26]
Amoxicillin	API Info	Acute otitis media [ICD-11: AB00]		[27]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[28]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[29]
Nadolol	API Info	Essential hypertension [ICD-11: BA00]		[30]
Methyldopa	API Info	Essential hypertension [ICD-11: BA00]		[31]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Sirolimus	API Info	Lymphangioleiomyomatosis [ICD-11: CB07]		[32]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[33]
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[34]
Dimenhydrinate	API Info	Functional nausea/vomiting [ICD-11: DD90]		[35]
Sodium fluoride	API Info	Periodontal disease [ICD-11: DA0C]		[36]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Naproxen	API Info	Rheumatoid arthritis [ICD-11: FA20]		[37]
Prednisone	API Info	Rheumatoid arthritis [ICD-11: FA20]		[38]
Raloxifene	API Info	Osteoporosis [ICD-11: FB83]		[39]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Erythromycin	API Info	Pelvic inflammatory disease [ICD-11: GA05]		[40]
Mefenamic acid	API Info	Dysmenorrhea [ICD-11: GA34]		[41]

References
1	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved prednisolone from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved hydroxyurea from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved simvastatin from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved potassium chloride from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved bromocriptine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved cabergoline from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved ziprasidone from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved clozapine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved amphetamine from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved desvenlafaxine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved carbamazepine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved oxymorphone from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved tapentadol from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved rasagiline from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved selegiline from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved nadolol from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved methyldopa from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved sirolimus from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved sodium fluoride from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved prednisone from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved erythromycin from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved mefenamic acid from the official website of the U.S. Food and Drug Administration.

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