General Information of DFM (ID: F23100)
Name	Capsaicin 8% Patch
Company	Averitas
Active Pharmaceutical Ingredient (API)	Capsaicin		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0QV6C	DIG Info	Butylhydroxyanisole	Antimicrobial preservative ...
	E0ME2Y	DIG Info	Diethylene glycol monoethyl ether	Solubilizing agent ...
	E0RB4Y	DIG Info	Dimethicone 350	Antifoaming agent ...
	E0FY2S	DIG Info	Edetate disodium	Complexing agent
	E0DK9Q	DIG Info	Ethyl cellulose	Coating agent ...
	E0G3NO	DIG Info	Polyethylene glycol 4000	Coating agent ...
	E03ORS	DIG Info	Silicone adhesive	Binding agent
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Muscarinic receptor M1 (ACM1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 19 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	ACM1_HUMAN
DBT Name: Alpha-1A adrenoceptor (ADA1A)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 19 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	ADA1A_HUMAN
Oxidoreductase (ORase)
DBT Name: Prostaglandin G/H synthase 2 (COX-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 2.6 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	PGH2_HUMAN
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyethylene glycol 4000
Biological Activity	Inhibition ratio < 40 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Nuclear receptor (NR)
DBT Name: Progesterone receptor (PGR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 29 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	PRGR_HUMAN
Other protein families (OPF)
DBT Name: Transthyretin (TTR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Diethylene glycol monoethyl ether
Biological Activity	IC50 = 10000 nM (estimated based on the structural similarity with CHEMBL155204 )					[3]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	TTHY_HUMAN
Cell line (CELL)
DBT Name: Cervical cancer HeLa cells (HeLa)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Diethylene glycol monoethyl ether
Biological Activity	IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL155204 )					[4]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0030
DBT Name: Ductal cancer PaCa-2 cells (MIA PaCa-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Diethylene glycol monoethyl ether
Biological Activity	IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL155204 )					[4]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0428
DBT Name: Lung cancer NCI-H460 cells (NCI-H460)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Diethylene glycol monoethyl ether
Biological Activity	IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL155204 )					[4]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0459

References
1	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
2	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
3	Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J Med Chem. 2019 Feb 28; 62(4):2076-2082.
4	Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores. J Med Chem. 2007 Mar 8; 50(5):1007-18.

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