Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0G3NO)
DIG Name	Polyethylene glycol 4000
DIG Function	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[1]
Ethambutol	API Info	Pulmonary tuberculosis [ICD-11: 1B10]		[2]
Ciprofloxacin	API Info	Endocarditis [ICD-11: 1B12]		[3]
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[4]
Valganciclovir	API Info	Cytomegalovirus infection [ICD-11: 1D82]		[5]
Dolutegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[6]
Rimantadine	API Info	Influenza virus infection [ICD-11: 1E30]		[7]
Moxifloxacin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[8]
Gemifloxacin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[9]
Voriconazole	API Info	Candidiasis [ICD-11: 1F23]		[10]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Bicalutamide	API Info	Prostate cancer [ICD-11: 2C82]		[11]
Imatinib	API Info	Leiomyosarcoma [ICD-11: 2B58]		[12]
Letrozole	API Info	Breast cancer [ICD-11: 2C60]		[13]
Trametinib	API Info	Melanoma [ICD-11: 2C30]		[14]
Enasidenib	API Info	Acute myeloid leukemia [ICD-11: 2A60]		[15]
Neratinib	API Info	Breast cancer [ICD-11: 2C60]		[16]
Rucaparib	API Info	Ovarian cancer [ICD-11: 2C73]		[17]
Bosutinib	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[18]
Ponatinib	API Info	Acute lymphoblastic leukemia [ICD-11: 2B33]		[19]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Simvastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[20]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[21]
Fluvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[22]
Alogliptin	API Info	Diabetes mellitus [ICD-11: 5A10]		[23]
Gemfibrozil	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[24]
Lorcaserin	API Info	Obesity [ICD-11: 5B81]		[25]
Dapagliflozin	API Info	Diabetes mellitus [ICD-11: 5A10]		[26]
Saxagliptin	API Info	Diabetes mellitus [ICD-11: 5A10]		[27]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[28]
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[29]
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[30]
Hydroxyzine	API Info	Anxiety disorder [ICD-11: 6B00]		[31]
Dexmethylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[32]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[33]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[34]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[35]
Prochlorperazine	API Info	Schizophrenia [ICD-11: 6A20]		[36]
Fluphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[37]
Trazodone	API Info	Major depressive disorder [ICD-11: 6A70]		[38]
Buprenorphine	API Info	Opiate dependence [ICD-11: 6C43]		[39]
Trifluoperazine	API Info	Schizophrenia [ICD-11: 6A20]		[40]
Citalopram	API Info	Major depressive disorder [ICD-11: 6A70]		[41]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[42]
Thioridazine	API Info	Schizophrenia [ICD-11: 6A20]		[43]
Naltrexone	API Info	Alcohol dependence [ICD-11: 6C40]		[44]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[45]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[46]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[47]
Tramadol	API Info	Anaesthesia [ICD-11: 8E22]		[48]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[49]
Memantine	API Info	Alzheimer disease [ICD-11: 8A20]		[50]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[51]
Zolmitriptan	API Info	Migraine [ICD-11: 8A80]		[52]
Tapentadol	API Info	Neuropathic pain [ICD-11: 8E43]		[53]
Sumatriptan	API Info	Migraine [ICD-11: 8A80]		[54]
Naratriptan	API Info	Migraine [ICD-11: 8A80]		[55]
Pimavanserin	API Info	Parkinsonism [ICD-11: 8A00]		[56]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Losartan	API Info	Essential hypertension [ICD-11: BA00]		[57]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[58]
Valsartan	API Info	Essential hypertension [ICD-11: BA00]		[59]
Benazepril	API Info	Essential hypertension [ICD-11: BA00]		[60]
Olmesartan	API Info	Essential hypertension [ICD-11: BA00]		[61]
Bisoprolol	API Info	Essential hypertension [ICD-11: BA00]		[62]
Quinapril	API Info	Essential hypertension [ICD-11: BA00]		[63]
Aliskiren	API Info	Essential hypertension [ICD-11: BA00]		[64]
Eprosartan	API Info	Essential hypertension [ICD-11: BA00]		[65]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Clarithromycin	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[66]
Fexofenadine	API Info	Allergic rhinitis [ICD-11: CA08]		[67]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Pantoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[68]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[69]
Rabeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[70]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[71]
Naloxegol	API Info	Irritable bowel syndrome [ICD-11: DD91]		[72]
Rolapitant	API Info	Functional nausea/vomiting [ICD-11: DD90]		[73]
Granisetron	API Info	Functional nausea/vomiting [ICD-11: DD90]		[74]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Propantheline	API Info	Excessive sweating [ICD-11: EE00]		[75]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[76]
Diclofenac	API Info	Knee osteoarthritis [ICD-11: FA01]		[77]
Etodolac	API Info	Rheumatoid arthritis [ICD-11: FA20]		[78]
Tolmetin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[79]
Raloxifene	API Info	Osteoporosis [ICD-11: FB83]		[80]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[81]
Oxybutynin	API Info	Overactive bladder [ICD-11: GC50]		[82]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[83]
Darifenacin	API Info	Overactive bladder [ICD-11: GC50]		[84]
ICD Disease Classification 17		Sexual health-related condition	Click to Show/Hide
Sildenafil	API Info	Erectile dysfunction [ICD-11: HA01]		[85]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio < 40 % (tested by experiment)		[86]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved ethambutol from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved ciprofloxacin from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved valganciclovir from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved dolutegravir from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved rimantadine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved moxifloxacin from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved gemifloxacin from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved voriconazole from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved bicalutamide from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved imatinib from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved letrozole from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved trametinib from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved enasidenib from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved neratinib from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved rucaparib from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved bosutinib from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved ponatinib from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved simvastatin from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved alogliptin from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved gemfibrozil from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved lorcaserin from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved dapagliflozin from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved saxagliptin from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved hydroxyzine from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved dexmethylphenidate from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved prochlorperazine from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved fluphenazine from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved trazodone from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved trifluoperazine from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved citalopram from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved thioridazine from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved naltrexone from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved memantine from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved zolmitriptan from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved tapentadol from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved naratriptan from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved pimavanserin from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved valsartan from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved benazepril from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved olmesartan from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved bisoprolol from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved quinapril from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved aliskiren from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved eprosartan from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved naldemedine from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved rolapitant from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved granisetron from the official website of the U.S. Food and Drug Administration.
75	Propantheline bromide in the management of hyperhidrosis associated with spinal cord injury. Ann Pharmacother. 1995 May;29(5):489-92.
76	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
77	FDA label for approved diclofenac from the official website of the U.S. Food and Drug Administration.
78	FDA label for approved etodolac from the official website of the U.S. Food and Drug Administration.
79	FDA label for approved tolmetin from the official website of the U.S. Food and Drug Administration.
80	FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
81	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
82	FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
83	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
84	FDA label for approved darifenacin from the official website of the U.S. Food and Drug Administration.
85	FDA label for approved sildenafil from the official website of the U.S. Food and Drug Administration.
86	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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