General Information of DFM (ID: F23724)
Name	Econazole Nitrate 1% cream
Company	Alvogen
Active Pharmaceutical Ingredient (API)	Econazole nitrate		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0NO1Z	DIG Info	Benzoic acid	Antimicrobial preservative
	E0QV6C	DIG Info	Butylhydroxyanisole	Antimicrobial preservative ...
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Glutamate receptor mGLU5 (mGluR5)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	EC50 > 10000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	GRM5_HUMAN
DBT Name: Muscarinic receptor M1 (ACM1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 19 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	ACM1_HUMAN
DBT Name: Alpha-1A adrenoceptor (ADA1A)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 19 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	ADA1A_HUMAN
Oxidoreductase (ORase)
DBT Name: D-amino acid oxidase (DAAO)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	Ki = 2000 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	OXDA_HUMAN
DBT Name: Prostaglandin G/H synthase 2 (COX-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 2.6 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	PGH2_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: FHA-HIT-interacting protein (NAPRT)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	Ki = 1.9 nM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	PNCB_HUMAN
Primary active transporter (PAT)
DBT Name: Bile salt export pump (BSEP)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	Ki = 260 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	ABCBB_HUMAN
Potential-driven transporter (PDT)
DBT Name: Organic anion transporter 6 (OAT6)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	Ki = 13800 nM (tested by experiment)					[5]
Tested Species	Mus musculus (Mouse)
UniProt ID	S22AK_MOUSE
DBT Name: Organic anion transporter 1 (OAT1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	Ki = 251188.64 nM (tested by experiment)					[5]
Tested Species	Mus musculus (Mouse)
UniProt ID	S22A6_MOUSE
DBT Name: Monoamine transporter VAT2 (VMAT2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzoic acid
Biological Activity	Ki = 18 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	VMAT2_HUMAN
Nuclear receptor (NR)
DBT Name: Progesterone receptor (PGR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 29 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	PRGR_HUMAN

References
1	Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor. J Med Chem. 2013 Sep 26; 56(18):7243-59.
2	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3	Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. J Med Chem. 2013 May 9; 56(9):3710-24.
4	WO patent application no. 2017162840A1, SENSITIZATION OF CANCER CELLS TO NAMPT INHIBITORS BY NICOTINIC ACID PHOSPHORIBOSYLTRANSFERASE NEUTRALIZATION.
5	Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.