Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23837)
Name
Naphazoline 0.05% solution
Company
Duy Drugs
Active Pharmaceutical Ingredient (API) Naphazoline API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0X1KL DIG Info Benzalkonium chloride Antimicrobial preservative ...
E0T4TW DIG Info Sodium chloride Diluent ...
E0M5SQ DIG Info Sodium citrate anhydrous Alkalizing agent ...
E09DYC DIG Info Sodium sulhydrate Antimicrobial preservative
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Monoamine oxidase (MAO) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzalkonium chloride
                    Biological Activity IC50 = 8200 nM (estimated based on the structural similarity with CHEMBL8695 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.97260274
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID AOFA_RAT ; AOFB_RAT
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sodium sulhydrate
                    Biological Activity Inhibition ratio < 90 % (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sodium citrate anhydrous
                    Biological Activity Ki = 99 nM (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
      Potential-driven transporter (PDT)
            DBT Name: Solute carrier SLCO2B1 (OATPB) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzalkonium chloride
                    Biological Activity Inhibition ratio = 77.4 % (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID SO2B1_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzalkonium chloride
                    Biological Activity Ki = 62.1 uM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID SO2B1_HUMAN
References
1 Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes. J Med Chem. 1983 Jul; 26(7):1036-42.
2 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
3 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
4 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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