Details of the Drug Formulation (DFM)

General Information of DFM (ID: F24261)
Name
Enoxacin 1% cream
Company
Biofrontera ; Cutanea Life Sciences
Active Pharmaceutical Ingredient (API) Enoxacin API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0NO1Z DIG Info Benzoic acid Antimicrobial preservative
E0QA6Q DIG Info Octyldodecanol Emollient ...
E0M1JK DIG Info Propylene glycol Antimicrobial preservative ...
E0XV1Z DIG Info Stearyl alcohol Emollient ...
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      G-protein coupled receptor (GPCR)
            DBT Name: Glutamate receptor mGLU5 (mGluR5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity EC50 > 10000 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID GRM5_HUMAN
      Oxidoreductase (ORase)
            DBT Name: D-amino acid oxidase (DAAO) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity Ki = 2000 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID OXDA_HUMAN
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Propylene glycol
                    Biological Activity Inhibition ratio < 20 % (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: FHA-HIT-interacting protein (NAPRT) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity Ki = 1.9 nM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PNCB_HUMAN
      Primary active transporter (PAT)
            DBT Name: Bile salt export pump (BSEP) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity Ki = 260 uM (tested by experiment) [5]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ABCBB_HUMAN
      Potential-driven transporter (PDT)
            DBT Name: Organic anion transporter 6 (OAT6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity Ki = 13800 nM (tested by experiment) [6]
                    Tested Species Mus musculus (Mouse)
                    UniProt ID S22AK_MOUSE
            DBT Name: Organic anion transporter 1 (OAT1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity Ki = 251188.64 nM (tested by experiment) [6]
                    Tested Species Mus musculus (Mouse)
                    UniProt ID S22A6_MOUSE
            DBT Name: Monoamine transporter VAT2 (VMAT2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzoic acid
                    Biological Activity Ki = 18 uM (tested by experiment) [5]
                    Tested Species Homo sapiens (Human)
                    UniProt ID VMAT2_HUMAN
References
1 Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor. J Med Chem. 2013 Sep 26; 56(18):7243-59.
2 Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. J Med Chem. 2013 May 9; 56(9):3710-24.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
4 WO patent application no. 2017162840A1, SENSITIZATION OF CANCER CELLS TO NAMPT INHIBITORS BY NICOTINIC ACID PHOSPHORIBOSYLTRANSFERASE NEUTRALIZATION.
5 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
6 Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.

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