Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01237)
Name
Meclofenamate sodium
Synonyms    Click to Show/Hide the Synonyms of This API
MECLOFENAMATE SODIUM; 6385-02-0; Meclomen; Sodium meclofenamate; Meclonax; Movens; Meclofenamic acid sodium salt; Meclofenamic acid sodium; Meclofenamate (sodium); MECLODIUM; Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate; UNII-9MMQ0YER4E; sodium 2-[(2,6-dichloro-3-methylphenyl)amino]benzoate; MFCD00077376; 9MMQ0YER4E; 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt; Meclofenamic acid (sodium); MLS000069578; CHEBI:6711; sodium;2-(2,6-dichloro-3-methylanilino)benzoate; SMR000058785; Meclomen (TN); Sodium meclophenamate; CHEMBL876; CL-583.NA SALT; Monosodium N-(2,6-dichloro-m-tolyl)anthranilate monohydrate; EINECS 228-983-3; CI 583; Meclofenamate sodium [USAN:USP]; Monosodium N-(2,6-dichloro-m-tolyl)anthranilate; N-(2,6-Dichloro-m-tolyl)anthranilic acid sodium salt; Opera_ID_596; Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, monosodium salt; Lopac-M-4531; Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt; MLS001056523; MLS001077271; SCHEMBL1649454; DTXSID8045567; sodium meclofenamate (anhydrous); HMS501J06; HMS2091B08; HMS2231H18; HMS3259F13; HMS3262A16; HMS3372D22; HMS3649O09; HMS3652L10; HMS3885H19; HY-B1320; Tox21_500727; ANW-41178; CCG-40117; s4295; AKOS009157878; CCG-267676; LP00727; MCULE-4652582072; NC00649; NE43592; Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate; NCGC00016169-01; NCGC00016169-02; NCGC00016169-03; NCGC00094073-01; NCGC00094073-02; NCGC00261412-01; DB-054565; 2-(2,6-dichloro-3-methyl-anilino)benzoate; AK00302035; CS-0013081; EU-0100727; FT-0603690; M1269; ST51015053; SW219723-1; EN300-51912; A12520; C02996; D08162; M 4531; Q27107307; sodium 2-(2,6-dichloro-3-methylphenylamino)benzoate; 2-([2,6-Dichloro-3-methylphenyl]amino)benzoic acid sodium; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid, sodium salt
Clinical Status
Approved
PubChem CID
4038
Formula
C14H10Cl2NNaO2
Canonical SMILES
CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
InChI
1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;/h2-7,17H,1H3,(H,18,19);/q;+1/p-1
InChIKey
OGPIIGMUPMPMNT-UHFFFAOYSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 318.1 Topological Polar Surface Area 52.2
XlogP N.A. Complexity 332
Heavy Atom Count 20 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Meclofenamate Sodium eq 50mg base capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Colloidal Silicon Dioxide; D&C Yellow No 10; Fd&C Blue No 1; Fd&C Red No 3; Gelatin; Magnesium Stearate; Microcrystalline Cellulose; Pregelatinized Starch (Corn); Sodium Lauryl Sulfate; Titanium Dioxide; Black Iron Oxide; D&C Yellow No 10 Aluminum Lake; Fd&C Blue No 1 Aluminum Lake; Fd&C Blue No 2 Aluminum Lake; Fd&C Red No 40 Aluminum Lake; Propylene Glycol; Shellac Glaze
                   Dosage Form Capsule
                   Company Mylan Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [1]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [1]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [1]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Erythrosine sodium anhydrous DIG Info Multidrug resistance protein 3 (IC50 = 133000 nM) [3]
Food blue 1 aluminum lake DIG Info Leukemia MT4 cells (IC50 = 1288.25 nM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [7]
References
1 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov; 136(1):216-41.
4 Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues. J Med Chem. 2006 Feb 23; 49(4):1291-312.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
7 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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