Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00179)
Name
Desipramine
Synonyms    Click to Show/Hide the Synonyms of This API
desipramine; Norimipramine; Desmethylimipramine; Desipramin; 50-47-5; Demethylimipramine; Monodemethylimipramine; Desimipramine; Dimethylimipramine; Dezipramine; Desimpramine; Methylaminopropyliminodibenzyl; 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE; desipraminum; Desipramina; Norpramine; Sertofran; DMI (pharmaceutical); N-(3-Methylaminopropyl)iminobibenzyl; 5-(gamma-Methylaminopropyl)iminodibenzyl; Imipramine, demethyl-; DMI 50475; UNII-TG537D343B; 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine; CHEMBL72; 10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azepine; CHEBI:47781; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-; TG537D343B; Desipramine (D4); (3-(10H,11H-Dibenzo[b,f]azepin-5-yl)propyl)methylamine; Pertrofane; 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-; Desipramine [INN:BAN]; Desipraminum [INN-Latin]; Desipramina [INN-Spanish]; Desmethylimipramine;Imipramine,demethyl-;Methylaminopropyliminodibenzyl; Desipramine (INN); CCRIS 7091; HSDB 3052; EX-4355; CAS-58-28-6; NCGC00015340-02; EINECS 200-040-0; BRN 1432747; Treyzafagit; 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-[3-(methylamino)propyl]-; Imipramine-M Nor; Desipramine;Norpramin; Pertofran (Salt/Mix); Spectrum_000441; Pertofrane (Salt/Mix); Prestwick0_000343; Prestwick1_000343; Prestwick2_000343; Prestwick3_000343; Spectrum2_000091; Spectrum3_000379; Spectrum4_000314; Spectrum5_000833; Lopac-D-3900; Lopac0_000358; SCHEMBL34384; BSPBio_000405; BSPBio_002137; KBioGR_000928; KBioSS_000921; DivK1c_000190; SPBio_000042; SPBio_002326; BPBio1_000447; GTPL2399; DTXSID6022896; BDBM35229; KBio1_000190; KBio2_000921; KBio2_003489; KBio2_006057; KBio3_001357; NINDS_000190; 10, 11-Dihydro-N-methyl-5H-dibez[b,f]azepine-5-propanamine; HMS3430H03; HMS3742I19; ALBB-025959; ZINC1530611; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine; 6943AB; SBB002569; STK735144; AKOS001681456; CCG-118231; DB01151; MCULE-5904286906; SDCCGSBI-0050346.P005; 4-(2H-Tetrazol-5-yl)phenylboronicacid; IDI1_000190; NCGC00015340-01; NCGC00015340-03; NCGC00015340-04; NCGC00015340-05; NCGC00015340-06; NCGC00015340-07; NCGC00015340-08; NCGC00015340-09; NCGC00015340-10; NCGC00015340-11; NCGC00015340-13; NCGC00015340-22; NCGC00024375-04; AC-15977; ST052019; SBI-0050346.P004; AB00053450; FT-0666024; C06943; D07791; AB00053450_14; 050D475; L001089; Q423288; BRD-K60762818-003-15-3; 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine; [3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine; 5H-Dibenzo[b, f]azepine, N-(3-methylaminopropyl)-, 10,11-Dihydro; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine #; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl);-N-methylpropan-1-amine
Clinical Status
Approved
Disease Indication Attention deficit hyperactivity disorder ICD-11: 6A05 [1]
PubChem CID
2995
Formula
C18H22N2
Canonical SMILES
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
InChI
1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
InChIKey
HCYAFALTSJYZDH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2995"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 266.4 Topological Polar Surface Area 15.3
XlogP 4.9 Complexity 267
Heavy Atom Count 20 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Desipramine 25 mg tablet Click to Show/Hide the Full List of Formulation(s):        12 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis; Winthrop
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Actavis Totowa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Hypromelloses; Povidones
                   Dosage Form Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Talc; Titanium dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Polyethylene glycol 8000; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Indicus Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (3 mpa.s); Microcrystalline cellulose; Polyethylene glycol, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (3 mpa.s); Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Desipramine 50 mg tablet Click to Show/Hide the Full List of Formulation(s):        12 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Winthrop
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Actavis Totowa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Hypromellose, unspecified; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Talc; Titanium dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Polyethylene glycol 8000; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Indicus Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (3 mpa.s); Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Desipramine 10 mg tablet Click to Show/Hide the Full List of Formulation(s):        11 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma; Kaiser Foundation Hospitals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis; Winthrop
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Actavis Totowa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Talc; Titanium dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Polyethylene glycol 8000; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Indicus Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (3 cps); Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (3 mpa.s); Microcrystalline cellulose; Polyethylene glycol, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (3 mpa.s); Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Desipramine 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis; Validus Pharmaceuticals; Winthrop
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Actavis Totowa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c yellow no. 6; Magnesium stearate; Ferric oxide red; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Talc; Titanium dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Polyethylene glycol 8000; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Indicus Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (3 cps); Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Desipramine 75 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; Calcium carbonate; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis; Validus Pharmaceuticals; Winthrop
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 1; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Actavis Totowa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; D&c red no. 27; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [6]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Talc; Titanium dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Polyethylene glycol 8000; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Indicus Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Desipramine 150 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; D&c red no. 30; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Acacia; Light mineral oil; Polyethylene glycol 8000; Starch, corn
                   Dosage Form Oral Tablet
                   Company Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Light mineral oil; Polyethylene glycol 8000
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis; Winthrop
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Povidone; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Actavis Totowa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Talc; Titanium dioxide; Cellulose, microcrystalline; Hypromellose 2910 (6 mpa.s); Polyethylene glycol 8000; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Indicus Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [6]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company CorePharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
References
1 FDA label for approved desipramine from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.
4 PubChem BioAssay data set.
5 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
6 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
7 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
8 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
9 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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