Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00390) | |||||
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Name |
Mefenamic acid
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Synonyms |
Click to Show/Hide the Synonyms of This API
mefenamic acid; 61-68-7; Ponstel; 2-[(2,3-dimethylphenyl)amino]benzoic acid; Ponstan; Mephenamic acid; Parkemed; Coslan; Mefacit; Ponalar; Methenamic acid; 2-((2,3-Dimethylphenyl)amino)benzoic acid; Mephenaminic acid; Mefenaminsaeure; Bonabol; Lysalgo; Tanston; Vialidon; Bafameritin-M; Tamany Bonsan; Ponstan forte; Acide mefenamique; Namphen; Pontal; Mefanamic acid; Bafhameritin-M; 2-(2,3-Dimethylanilino)benzoic acid; CN-35355; Mefenacid; Ponstil; Ponstyl; N-2,3-Xylylanthranilic acid; N-(2,3-Xylyl)anthranilic acid; INF 3355; INF-3355; Acido mefenamico; Acidum mefenamicum; N-(2,3-Xylyl)-2-aminobenzoic acid; N-(2,3-Dimethylphenyl)anthranilic acid; AGN-1255; CI-473; CL 473; Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-; Anthranilic acid, N-2,3-xylyl-; CN 35355; NSC 94437; 2-(2,3-dimethylphenylamino)benzoic acid; UNII-367589PJ2C; Anthranilic acid, N-(2,3-xylyl)-; Benzoic acid, 2-((2,3-dimethylphenyl)amino)-; CI 473; MFCD00051721; 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl-; CHEMBL686; MLS000069709; CHEBI:6717; NSC94437; NSC-94437; 367589PJ2C; CAS-61-68-7; NCGC00016278-07; SMR000058188; DSSTox_CID_3243; Mefenaminsaeure [German]; DSSTox_RID_76938; DSSTox_GSID_23243; Ac. mefenamico [Italian]; Acide mefenamique [French]; Acide mefenamique [INN-French]; Acido mefenamico [INN-Spanish]; Acidum mefenamicum [INN-Latin]; 2-(2,3-Xylidino)benzoic Acid; HSDB 3115; SR-01000000216; EINECS 200-513-1; BRN 2216243; Prestwick_506; Mefenamic Acid,(S); Spectrum_000174; CPD000058188; Opera_ID_542; Mefenamic acid [USAN:USP:INN:BAN:JAN]; Prestwick0_000054; Prestwick1_000054; Prestwick2_000054; Prestwick3_000054; Spectrum2_001941; Spectrum3_001082; Spectrum4_001235; Spectrum5_001341; Benzoic acid, 2-(2,3-dimethylphenyl)amino-; Anthranilic acid,3-xylyl-; cid_4044; SCHEMBL3544; Oprea1_193889; BSPBio_000207; BSPBio_002724; KBioGR_001730; KBioSS_000654; MLS001074162; DivK1c_000298; SPECTRUM1501103; SPBio_002001; SPBio_002128; BPBio1_000229; F0850-6853; GTPL2593; SGCUT00005; WLN: QVR BMR B1 C1; DTXSID5023243; HMS500O20; KBio1_000298; KBio2_000654; KBio2_003222; KBio2_005790; KBio3_001944; ZINC20241; BRD8217; M01AG01; NINDS_000298; HMS1568K09; HMS1921D13; HMS2090B07; HMS2092B17; HMS2095K09; HMS2232P18; HMS3259M19; HMS3370K18; HMS3652A10; HMS3712K09; HMS3885O22; Pharmakon1600-01501103; Mefenamic acid (JP17/USP/INN); Mefenamic acid, analytical standard; ALBB-025759; BCP08499; BRD-8217; HY-B0574; to_000071; Tox21_110344; Tox21_301983; BBL003564; BDBM50134036; CCG-39434; NSC757834; SBB056999; STK666691; AKOS001025551; AKOS002388313; Benzoic acid,3-dimethylphenyl)amino]-; Tox21_110344_1; DB00784; J2.344B; MCULE-1031776135; NC00517; NSC-757834; IDI1_000298; SMP2_000141; 2-(2,3-Dimethylanilino)benzoic acid #; NCGC00016278-01; NCGC00016278-02; NCGC00016278-03; NCGC00016278-04; NCGC00016278-05; NCGC00016278-06; NCGC00016278-10; NCGC00022393-03; NCGC00022393-04; NCGC00022393-05; NCGC00255401-01; AC-11160; AK-72920; AS-12677; BR-72920; ST086740; SBI-0051636.P002; 2-(2,3-Dimethyl-phenylamino)-benzoic acid; AB0012318; 2-[(2,3-dimethylphenyl) amino]benzoic acid; 2-Diphenylaminecarboxylic acid,3'-dimethyl-; AB00052200; AM20060688; FT-0628184; SW196700-3; UNM000001233403; C02168; D00151; M-6454; AB00052200-17; AB00052200_18; AB00052200_19; A833367; Q284321; SR-01000000216-2; SR-01000000216-4; W-105113; BRD-K92778217-001-06-1; Z56755828; 2-(2,3-Dimethyl-phenylamino)-benzoic acid(Mefenamic acid); Mefenamic acid, European Pharmacopoeia (EP) Reference Standard; Mefenamic acid, United States Pharmacopeia (USP) Reference Standard
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Clinical Status |
Approved
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Disease Indication | Dysmenorrhea | ICD-11: GA34 | [1] | ||
PubChem CID | |||||
Formula |
C15H15NO2
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Canonical SMILES |
CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C
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InChI |
1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
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InChIKey |
HYYBABOKPJLUIN-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4044"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 241.28 | Topological Polar Surface Area | 49.3 | |
XlogP | 5.1 | Complexity | 292 | ||
Heavy Atom Count | 18 | Rotatable Bond Count | 3 | ||
Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 3 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Mefenamic acid 250 mg capsule | Click to Show/Hide the Full List of Formulation(s): 8 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Citric acid; Lactose; Sodium benzoate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Gelatin; Glycerol monooleate
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Dosage Form | Oral Capsule | |||||
Company | Sciele Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Kyselina citronova | DIG Info | Perilipin-1 (IC50 = 3708 nM) | [3] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Sodium benzoate | DIG Info | Carbonic anhydrase II (Ki = 30000 nM) | [5] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [6] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium benzoate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Citric acid monohydrate; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Gelatin
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Dosage Form | Oral Capsule | |||||
Company | Prasco | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Sodium benzoate | DIG Info | Carbonic anhydrase II (Ki = 30000 nM) | [5] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [6] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium benzoate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Citric acid monohydrate; Titanium dioxide; Fd&c red no. 3; Silicon dioxide; Gelatin, unspecified
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Dosage Form | Oral Capsule | |||||
Company | Shionogi | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Sodium benzoate | DIG Info | Carbonic anhydrase II (Ki = 30000 nM) | [5] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [4] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [6] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Fd&c red no. 3; Gelatin; Shellac
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Dosage Form | Oral Capsule | |||||
Company | Lupin Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [7] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [6] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Fd&c red no. 3; Gelatin; Shellac
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Dosage Form | Oral Capsule | |||||
Company | Micro Labs | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [7] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [4] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Fd&c red no. 3; Gelatin; Shellac
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Dosage Form | Oral Capsule | |||||
Company | Paddock Laboratories, | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [7] | |||
FD&C red no. 3 | DIG Info | Phosphodiesterase 3A (IC50 = 0.092 uM) | [4] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Ferric oxide yellow; Propylene glycol; Titanium dioxide; Dimethicone; Gelatin; Shellac
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Dosage Form | Oral Capsule | |||||
Company | Belcher Pharmaceuticals; Qualitest Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [2] | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [4] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [7] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Butyl alcohol; Fd&c blue no. 2; Isopropyl alcohol; Ammonia; Ferric oxide yellow; Propylene glycol; Titanium dioxide; Alcohol; Gelatin; Shellac
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Dosage Form | Oral Capsule | |||||
Company | Breckenridge Pharmaceutical; Solubiomix | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 2 | DIG Info | Adenosine receptor A3 (IC50 = 1 uM) | [4] | |||
Isopropyl alcohol | DIG Info | Lymphoma P388/ADR cells (IC50 = 0.22 uM) | [8] | |||
Propylene glycol | DIG Info | Albendazole monooxygenase (Inhibition ratio < 20 %) | [7] | |||
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