Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00412)
Name
Methotrexate
Synonyms    Click to Show/Hide the Synonyms of This API
methotrexate; Rheumatrex; Amethopterin; Abitrexate; Trexall; Metatrexan; Methylaminopterinum; Methotrexate hydrate; Methylaminopterin; 4-Amino-10-methylfolic acid; Methotrexatum; Metotrexato; Maxtrex; Rasuvo; Mexate-Aq; N-Bismethylpteroylglutamic acid; NSC-740; NCI-C04671; Methotrexate Lpf; METHOTREXATE SODIUM; 133073-73-1; CL-14377; UNII-YL5FZ2Y5U1; Amethopterine; Farmitrexat; EMT 25,299; L-Amethopterin; Methotrexat-Ebewe; TCMDC-125858; (+)-4-Amino-10-methylfolic acid; Abitrexate (Methotrexate); R 9985; YL5FZ2Y5U1; Methotextrate; Methotrexat; CL 14377; 59-05-2 (free acid); CHEMBL34259; NSC740; CHEBI:44185; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; NCGC00025060-04; NSC 740; C20H22N8O5; 4-amino-N(10)-methylpteroylglutamic acid; A-Methopterin; DSSTox_CID_822; A-Methpterin; Amethopterin L-; Folex-Pfs; MFCD00150847; DSSTox_RID_75810; Methotrexate, L-; DSSTox_GSID_20822; R-methotrexate; Metotressato [DCIT]; Fauldexato; Medsatrexate; Methoblastin; Metotressato; Brimexate; Emthexat; Emthexate; Lantarel; Lumexon; Metrotex; Novatrex; Otrexup; Tremetex; Trexeron; Trixilem; Texate; MLS001401431; Methotrexatum [INN-Latin]; Metotrexato [INN-Spanish]; [3H]methotrexate; SMR000112001; [3H]-methotrexate; CCRIS 1109; 4-Aminomethylpteroylglutamic acid; HSDB 3123; L-(+)-N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-(+)-glutamic acid; SR-01000075682; SMR000449324; EINECS 200-413-8; Metolate; Nordimet; Xatmep; AI3-25299; Antifolan hydrate; Intradose-MTX; MTX hydrate; 4-Amino-N(sup 10)-methylpteroylglutamic acid; CAS-59-05-2; Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, L-; Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova; MPI-2505; Prestwick_322; Otrexup (TN); Methotrexate solution; Xatmep (TN); folic acid antagonist; An-PDN; CL14377; L-METHOTREXATE; Kyselina 4-amino-N(sup 10)-methylpteroylglutamova [Czech]; Methylaminopterin; MTX; DL-Amethopterin hydrate; Methotrexate [USAN:USP:INN:BAN:JAN]; Spectrum_001836; Tocris-1230; WR-19039; Methylaminopterin hydrate; Prestwick0_000135; Prestwick1_000135; Prestwick2_000135; Spectrum2_001077; Spectrum3_000497; Spectrum4_000616; Spectrum5_000958; Methotrexate - Abitrexate; N-(p-(((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid; L(+)-Amethopterin hydrate; N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamicacid; NCIMech_000767; SCHEMBL3711; BIDD:PXR0175; Lopac0_000020; KBioGR_001172; KBioSS_002341; Kyselina 4-amino-N(sup 10)-methylpteroylglutamova; MLS000049968; MLS002154208; DivK1c_000114; SPBio_001094; SPBio_002149; cid_126941; cid_165528; GTPL4674; GTPL4815; DTXSID4020822; SCHEMBL12421860; BDBM18050; BDBM66082; HMS500F16; KBio1_000114; KBio2_002338; KBio2_004906; KBio2_007474; KBio3_001493; Methotrexate (JP17/USP/INN); AOB5585; NINDS_000114; Bio1_000486; Bio1_000975; Bio1_001464; HMS1568K12; HMS2095K12; HMS2233O18; HMS3260C21; HMS3414L09; HMS3678L07; HMS3712K12; ACT03341; ADX-2191; APC-2002; BCP13701; MPI-5004; ZINC1529323; Tox21_110944; Tox21_300269; Tox21_500020; 4-Amino-10-methylfolic acid hydrate; ANW-72813; CCG-35800; EMT-25299; MFCD00064370; STL535338; (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid; AKOS016340329; Tox21_110944_1; AB02593; ACN-050905; CS-1732; DB00563; KS-5093; LP00020; MCULE-6523054194; SDCCGSBI-0050009.P003; IDI1_000114; N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid; SMP2_000020; (methyl)amino)benzamido)pentanedioic acid; NCGC00025060-01; NCGC00025060-02; NCGC00025060-03; NCGC00025060-05; NCGC00025060-06; NCGC00025060-07; NCGC00025060-08; NCGC00025060-09; NCGC00025060-10; NCGC00025060-11; NCGC00025060-12; NCGC00025060-13; NCGC00025060-15; NCGC00025060-16; NCGC00254216-01; NCGC00260705-01; BR-77824; HY-14519; EU-0100020; SW198601-3; Methotrexate 1.0 mg/ml in Dimethyl Sulfoxide; 1771-EP0930075A1; 1771-EP2269989A1; 1771-EP2269994A1; 1771-EP2270001A1; 1771-EP2270008A1; 1771-EP2270018A1; 1771-EP2270505A1; 1771-EP2272825A2; 1771-EP2272827A1; 1771-EP2272832A1; 1771-EP2275413A1; 1771-EP2275420A1; 1771-EP2277565A2; 1771-EP2277566A2; 1771-EP2277567A1; 1771-EP2277568A2; 1771-EP2277569A2; 1771-EP2277570A2; 1771-EP2277865A1; 1771-EP2277876A1; 1771-EP2280012A2; 1771-EP2281563A1; 1771-EP2281815A1; 1771-EP2287156A1; 1771-EP2289892A1; 1771-EP2289894A2; 1771-EP2292233A2; 1771-EP2292280A1; 1771-EP2292595A1; 1771-EP2292614A1; 1771-EP2292615A1; 1771-EP2292617A1; 1771-EP2295055A2; 1771-EP2295416A2; 1771-EP2295426A1; 1771-EP2295427A1; 1771-EP2298743A1; 1771-EP2298748A2; 1771-EP2298764A1; 1771-EP2298765A1; 1771-EP2298768A1; 1771-EP2298772A1; 1771-EP2298778A1; 1771-EP2298780A1; 1771-EP2301928A1; 1771-EP2301933A1; 1771-EP2305243A1; 1771-EP2305640A2; 1771-EP2305642A2; 1771-EP2305660A1; 1771-EP2305668A1; 1771-EP2305671A1; 1771-EP2305679A1; 1771-EP2305689A1; 1771-EP2308833A2; 1771-EP2308839A1; 1771-EP2308855A1; 1771-EP2308861A1; 1771-EP2311453A1; 1771-EP2311807A1; 1771-EP2311808A1; 1771-EP2311825A1; 1771-EP2311827A1; 1771-EP2311829A1; 1771-EP2311840A1; 1771-EP2311842A2; 1771-EP2311850A1; 1771-EP2314590A1; 1771-EP2316459A1; 1771-EP2316832A1; 1771-EP2316833A1; 1771-EP2316834A1; 1771-EP2371811A2; 1771-EP2374454A1; 5947-EP0930075A1; 5947-EP2269994A1; 5947-EP2289892A1; 73M731; A-2190; A10021; C01937; D00142; J10045; R-9985; DL-4-Amino-N10-methylpteroylglutamic acid hydrate; Q422232; SR-01000597411; W-60383; (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl); Q-201366; SR-01000075682-1; SR-01000075682-2; SR-01000075682-6; SR-01000597411-1; W-105347; 2,2'-(9,10-anthracenediylidene)-bis-propanedinitrile; BRD-K59456551-001-09-3; BRD-K59456551-001-11-9; WLN: T66 BN DN GN JNJ CZ EZ H1N1&R DVMYVQ2VQ; Z1541638527; N,N,N,N-ETHYLENEDIAMINETETRA(METHYLENEPHOSPHONICACID); UNII-99ITO15X8S component FBOZXECLQNJBKD-ZDUSSCGKSA-N; Methotrexate, European Pharmacopoeia (EP) Reference Standard; Methotrexate, United States Pharmacopeia (USP) Reference Standard; Glutamic acid,4-diamino-6-pteridinyl)methyl] methylamino]benzoyl]-, L-(+)-; L-Glutamic acid,4-diamino-6-pteridinyl)methyl]- methylamino]benzoyl]-; Methotrexate, Pharmaceutical Secondary Standard; Certified Reference Material; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl] methylamino]benzoyl]-L-glutamic acid; 102613-64-9; 70359-39-6
Clinical Status
Approved
Disease Indication Breast cancer ICD-11: 2C60 [1]
PubChem CID
126941
Formula
C20H22N8O5
Canonical SMILES
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI
1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChIKey
FBOZXECLQNJBKD-ZDUSSCGKSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=126941"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 454.4 Topological Polar Surface Area 211
XlogP -1.8 Complexity 704
Heavy Atom Count 33 Rotatable Bond Count 9
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 12
Full List of Drug Formulations (DFMs) Containing This API
          Methotrexate 15 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Fd&c red no. 40; Fd&c blue no. 2; Indigotindisulfonate sodium; Magnesium stearate; Sodium carbonate monohydrate; Talc; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Women's Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Methotrexate 5 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Sodium carbonate monohydrate; Talc; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Women's Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Methotrexate 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Fd&c red no. 40; Magnesium stearate; Sodium carbonate monohydrate; Talc; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Women's Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Methotrexate 7.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Fd&c blue no. 1; Magnesium stearate; Sodium carbonate monohydrate; Talc; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Women's Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
          Methotrexate 2.5 mg tablet Click to Show/Hide the Full List of Formulation(s):        12 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c red no. 40; Magnesium stearate; Sodium carbonate monohydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Propylene glycol; Sodium carbonate monohydrate; Talc; Cellulose, microcrystalline; Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Propylene glycol; Sodium carbonate monohydrate; Talc; Cellulose, microcrystalline; Hypromellose 2208 (100000 mpa.s); Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Propylene glycol; Sodium carbonate monohydrate; Talc; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Propylene glycol; Sodium carbonate monohydrate; Talc; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Propylene glycol; Sodium carbonate monohydrate; Talc; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; AvKARE; Barr Laboratories; PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Cadila Healthcare; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Sodium hydroxide; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Dispensing Solution; GenPak Solutions; Major Pharmaceuticals; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; DAVA Pharmaceuticals; PD-Rx Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Methotrexate Sodium 2.5mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose Monohydrate; Microcrystalline Cellulose; Magnesium Stearate
                   Dosage Form Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous Lactose; Magnesium Stearate; Starch, Corn
                   Dosage Form Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose Monohydrate; Magnesium Stearate; Starch, Corn
                   Dosage Form Tablet
                   Company Avkare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved methotrexate from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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