Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00531) | |||||
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Name |
Pimavanserin
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Synonyms |
Click to Show/Hide the Synonyms of This API
Pimavanserin; 706779-91-1; 1-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea; ACP-103; UNII-JZ963P0DIK; Pimavanserin free base; JZ963P0DIK; 1-[(4-fluorophenyl)methyl]-1-(1-methylpiperidin-4-yl)-3-[[4-(2-methylpropoxy)phenyl]methyl]urea; 706779-91-1 (free base); N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide; N-(4-Fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide; Pimavanserin [INN]; 706782-28-7; Pimanavserin; methyltrimethylacetate; AC-5273; Pimavanserin(ACP-103); SCHEMBL675165; Nuplazid (proposed trade name); GTPL8423; CHEMBL2111101; C25H34FN3O2; DTXSID90990906; CHEBI:133017; BDBM139370; HMS3742A03; BCP11618; EBD38047; MFCD09953792; ZINC16159083; AKOS015902593; CS-3378; DB05316; ME-0240; SB16963; NCGC00390656-01; NCGC00390656-02; HY-14557; FT-0653701; A14434; 779P911; A836958; J-503297; Q7194603; 1-[(4-fluorophenyl)methyl]-1-(1-methyl-4-piperidinyl)-3-[[4-(2-methylpropoxy)phenyl]methyl]urea; N-[(4-Fluorophenyl)methyl]-N-(1-methylpiperidin-4-yl)-N'-{[4-(2-methylpropoxy)phenyl]methyl}carbamimidic acid; N-[(4-fluorophenyl)methyl]-N-(1-methylpiperidin-4-yl)-N'-{[4-(2-methylpropoxy)phenyl]methyl}urea
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Clinical Status |
Approved
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Disease Indication | Parkinsonism | ICD-11: 8A00 | [1] | ||
PubChem CID | |||||
Formula |
C25H34FN3O2
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Canonical SMILES |
CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C
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InChI |
1S/C25H34FN3O2/c1-19(2)18-31-24-10-6-20(7-11-24)16-27-25(30)29(23-12-14-28(3)15-13-23)17-21-4-8-22(26)9-5-21/h4-11,19,23H,12-18H2,1-3H3,(H,27,30)
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InChIKey |
RKEWSXXUOLRFBX-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=10071196"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 427.6 | Topological Polar Surface Area | 44.8 | |
XlogP | 4.5 | Complexity | 523 | ||
Heavy Atom Count | 31 | Rotatable Bond Count | 8 | ||
Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 4 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Pimavanserin 17 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Saccharin sodium anhydrous; Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 3350; Hypromellose 2910 (15 mpa.s); Microcrystalline cellulose; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | ACADIA Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Saccharin sodium anhydrous | DIG Info | Carbonic anhydrase I (Ki = 18540 nM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Polyethylene glycol 3350 | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [3] | |||
Pimavanserin Tartrate 10 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium Stearate; Pregelatinized Starch; Silicified Microcrystalline Cellulose; Polyethylene Glycol; Polyvinyl Alcohol; Red Iron Oxide; Talc; Titanium Dioxide; Yellow Iron Oxide
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Dosage Form | Tablet | |||||
Company | Acadia Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Polyvinyl alcohol | DIG Info | Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Polyethylene glycol 4000 | DIG Info | Albendazole monooxygenase (Inhibition ratio < 40 %) | [5] | |||
Pregelatinized starch | DIG Info | Multidrug resistance protein 1 (Protein expression downregulation) | [3] | |||
Pimavanserin Tartrate 34 mg capsule | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium Stearate; Microcrystalline Cellulose; Black Iron Oxide; Fd&C Blue 1; Hypromellose; Titanium Dioxide; Yellow Iron Oxide
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Dosage Form | Capsule | |||||
Company | Acadia Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
FD&C blue no. 1 | DIG Info | Solute carrier SLCO2B1 (Ki = 13 uM) | [6] | |||
Hypromellose | DIG Info | Cytochrome P450 3A5 (IC50 = 19.4 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
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