Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00639)
Name
Stavudine
Synonyms    Click to Show/Hide the Synonyms of This API
stavudine; 3056-17-5; sanilvudine; 2',3'-Didehydro-3'-deoxythymidine; Zerit Xr; BMY-27857; Estavudina; Stavudinum; Stavudinum [INN-Latin]; 2',3'-Anhydrothymidine; Estavudina [INN-Spanish]; Thymidine, 2',3'-didehydro-3'-deoxy-; 3'-Deoxy-2'-thymidinene; ddeThd; 2',3'-Didehydro-3'-deoxythimidine; BMY 27857; 3'-Deoxy-2',3'-didehydrothymidine; Dideoxydidehydrothymidine; UNII-BO9LE4QFZF; 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine; BO9LE4QFZF; CHEMBL991; Zerut XR; MLS000028546; CHEBI:63581; Stavudine (d4T); NSC 163661; 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione; NCGC00023212-07; SMR000058350; D 4T (nucleoside); DSSTox_CID_3819; DSSTox_RID_77198; DSSTox_GSID_23819; Stavudine [USAN:BAN:INN]; ddeTyd; CAS-3056-17-5; Zerit(TM); Sanilvudine (JAN); 3'-Deoxy-2',3'-didehydrothymidine, 98%; Zerit (TN); HSDB 7338; SR-01000075802; Stavudine (USAN/INN); BRN 0618327; D4T & GM-CSF; 2'-Thymidinene, 3'-deoxy-; MFCD00132921; NSC163661; NSC-163661; Stavudine [USAN:USP:INN:BAN]; D4TMBY-27857-3; PubChem5805; Opera_ID_1281; 3'-deoxythymidin-2'-ene; D 1413; cid_5155; 3''-deoxy-2''-thymidine; Lopac0_000336; SCHEMBL38661; cid_18283; MLS000759504; MLS001055348; MLS001077292; MLS001424091; MLS006011922; BIDD:GT0082; 2',3'-Anhydrothymidine; d4T; DTXSID1023819; 1-(2,3-Dideoxy-beta-D-glycero-2-pentenofuranosyl)thymine; HMS2051O20; HMS2234C10; HMS3039O05; HMS3259L21; HMS3261C13; HMS3428C07; HMS3714N22; Pharmakon1600-01502339; ZINC137884; BCP02952; HY-B0116; Tox21_110886; Tox21_201393; Tox21_300583; Tox21_500336; ABP000995; ANW-26914; BBL033763; BDBM50013111; NSC759897; STK801888; 2',3'-Didehydro-3'-deoxy-thymidine; AKOS005622554; Thymine, 1-(2,3-dideoxy-beta-D-glycero-pent-2-enofuranosyl)- (7CI,8CI); Tox21_110886_1; AC-5263; CCG-100902; CS-1872; DB00649; KS-1115; LP00336; MCULE-9252477726; NC00152; NC00684; NSC-759897; SDCCGSBI-0050324.P002; 2'',3''-didehydro-3''-deoxythymidine; 3''-deoxy-2'',3''-didehydrothymidine; 3'-Deoxy-2',3'-didehydro-D-thymidine; NCGC00023212-03; NCGC00023212-04; NCGC00023212-05; NCGC00023212-08; NCGC00023212-09; NCGC00023212-10; NCGC00023212-11; NCGC00023212-12; NCGC00023212-13; NCGC00023212-14; NCGC00023212-25; NCGC00254372-01; NCGC00258944-01; NCGC00261021-01; BR-77340; SMR000673569; 2',3'-didehydro-2',3'-dideoxythymidine; AB0013374; Thymidine, 2',3'-didehydro-, 3'-deoxy-; EU-0100336; 2'',3''-dideoxy-2'',3''-didehydrothymidine; C07312; D00445; J10003; S-2155; AB00383018_18; 056S175; A820433; Q423984; J-700246; Q-201742; SR-01000075802-1; SR-01000075802-4; 2',3'-Didehydro-3'-deoxythymidine, >=98% (TLC); Z1695906749; Stavudine, European Pharmacopoeia (EP) Reference Standard; 1-(2,3-Dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)thymine; Stavudine, United States Pharmacopeia (USP) Reference Standard; 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; 3'- Azido-3'-deoxythymidine & Granulocyte-macrophage colony-stimulating factor; Stavudine for system suitability, European Pharmacopoeia (EP) Reference Standard; 220020-60-0
Clinical Status
Approved
Disease Indication Human immunodeficiency virus infection ICD-11: 1C60 [1]
PubChem CID
18283
Formula
C10H12N2O4
Canonical SMILES
CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@H](O2)CO
InChI
1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
InChIKey
XNKLLVCARDGLGL-JGVFFNPUSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=18283"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 224.21 Topological Polar Surface Area 78.9
XlogP -0.8 Complexity 388
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Stavudine 15 mg capsule Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Stavudine 30 mg capsule Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Fd&c yellow no. 6; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Stavudine 20 mg capsule Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 28; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 28; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Stavudine 40 mg capsule Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 28; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Gelatin; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Camber Pharmaceuticals; Kaiser Foundation Hospitals; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved stavudine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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