General Information of DFM (ID: F05863)
Name
Didanosine 250 mg capsule
Company
Bristol-Myers Squibb Company
Active Pharmaceutical Ingredient (API) Didanosine API Info click to show the detail info of this API
Human immunodeficiency virus infection ICD-11: 1C60 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0UN4C DIG Info Carboxymethylcellulose sodium Adsorbent ...
E0N6BJ DIG Info Diethyl phthalate Plasticizing agent ...
E0L2PN DIG Info Sodium hydroxide Alkalizing agent
E0QY1F DIG Info Talc Anticaking agent ...
E05BSD DIG Info Titanium dioxide Coating agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Carboxymethylcellulose sodium
                    Biological Activity EC50 = 12.6 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
            DBT Name: Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Carboxymethylcellulose sodium
                    Biological Activity EC50 = 113.2 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2C9_HUMAN
            DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Carboxymethylcellulose sodium
                    Biological Activity EC50 = 373.8 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2CJ_HUMAN
            DBT Name: Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Carboxymethylcellulose sodium
                    Biological Activity EC50 = 83.7 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A5_HUMAN
      Hydrolase (HDase)
            DBT Name: Phosphodiesterase 4D (PDE4D) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Diethyl phthalate
                    Biological Activity IC50 = 8.5 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PDE4D_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Cholesterol 25-hydroxylase (CYP1A2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Carboxymethylcellulose sodium
                    Biological Activity IC50 = 224.7 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP1A2_HUMAN
      Cell line (CELL)
            DBT Name: Lung cancer A-549 cells (A-549) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Diethyl phthalate
                    Biological Activity IC50 = 38000 nM (estimated based on the structural similarity with CHEMBL4071043 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.970588235
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0023
References
1 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Novel bioactive molecules from Lentzea violacea strain AS 08 using one strain-many compounds (OSMAC) approach. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2579-2582.

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