Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0UN4C)
DIG Name	Carboxymethylcellulose sodium
DIG Function	Adsorbent; Binding agent; Disintegrant; Emulsifying agent; Suspending agent; Viscosity-controlling agent

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Didanosine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[1]
Dicloxacillin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[2]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[3]
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[4]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Hydroxyurea	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[5]
Tamoxifen	API Info	Breast cancer [ICD-11: 2C60]		[6]
Alectinib	API Info	Lung cancer [ICD-11: 2C25]		[7]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[8]
Atorvastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[9]
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[10]
Fluvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[11]
Omega-3 carboxylic acid	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[12]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[13]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[14]
Escitalopram	API Info	Major depressive disorder [ICD-11: 6A70]		[15]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[16]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[17]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[18]
Ethotoin	API Info	Focal seizure [ICD-11: 8A68]		[19]
Rufinamide	API Info	Lennox-gastaut syndrome [ICD-11: 8A62]		[20]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Cephalexin	API Info	Acute otitis media [ICD-11: AB00]		[21]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Diltiazem	API Info	Essential hypertension [ICD-11: BA00]		[22]
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[23]
Metoprolol	API Info	Essential hypertension [ICD-11: BA00]		[24]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Cefpodoxime	API Info	Bronchitis [ICD-11: CA20]		[25]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[26]
Mesalamine	API Info	Inflammatory bowel disease [ICD-11: DD72]		[27]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[28]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[29]
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[30]
Metaxalone	API Info	Myalgia [ICD-11: FB56]		[31]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[32]
Erythromycin	API Info	Pelvic inflammatory disease [ICD-11: GA05]		[33]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[34]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 12.6 uM (tested by experiment)		[35]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 113.2 uM (tested by experiment)		[35]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 373.8 uM (tested by experiment)		[35]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2CJ_HUMAN
DBT Name: Cytochrome P450 3A5 (CYP3A5)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 83.7 uM (tested by experiment)		[35]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A5_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 224.7 uM (tested by experiment)		[35]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN

References
1	FDA label for approved didanosine from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved dicloxacillin from the official website of the U.S. Food and Drug Administration.
3	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
4	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved hydroxyurea from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved tamoxifen from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved alectinib from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved omega-3 carboxylic acid from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved escitalopram from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved ethotoin from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved rufinamide from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved cephalexin from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved diltiazem from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved metoprolol from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved cefpodoxime from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved mesalamine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved metaxalone from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved erythromycin from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
35	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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