General Information of DFM (ID: F06206)
Name	Dimenhydrinate 25 mg tablet
Company	Medtech Products
Active Pharmaceutical Ingredient (API)	Dimenhydrinate		API Info click to show the detail info of this API
	Functional nausea/vomiting		ICD-11: DD90	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0BI3X	DIG Info	Aspartame	Flavoring agent
	E09QIG	DIG Info	Citric acid monohydrate	Acidulant ...
	E04KSN	DIG Info	Hexahydric alcohol	Diluent ...
	E01UTP	DIG Info	Magnesium stearate	lubricant

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Hydrolase (HDase)
DBT Name: Matrix metalloproteinase-1 (MMP1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Aspartame
Biological Activity	IC50 = 20000 nM (estimated based on the structural similarity with CHEMBL62186 )					[2]
Structural Similarity	Tanimoto coefficient = 0.916666667
Tested Species	Homo sapiens (Human)
UniProt ID	MMP1_HUMAN
Nuclear receptor (NR)
DBT Name: Pregnane X receptor (NR1I2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Aspartame
Biological Activity	Ki = 13 uM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	NR1I2_HUMAN

References
1	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2	Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket. Bioorg Med Chem Lett. (1997) 7:193-198.
3	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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